Scopus İndeksli Yayınlar Koleksiyonu by Institution Author "Akar, Remzi Okan"
Now showing items 1-5 of 5
-
Highly promising antitumor agent of a novel Platinum(II) complex bearing a tetradentate chelating ligand
Yılmaz, İsmail; Akar, Remzi Okan; Erkısa Genel, Merve; Selvi, Selin; Şengül, Abdurrahman; Ulukaya, Engin (Amer Chemical Soc, 2020)A new mononuclear cationic platinum(II) coordination compound with 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine (L) ligand having N-4-tetradentate binding pocket [Pt(L)]-Cl-2.2H(2)O (Complex 1) was synthesized and ... -
Key actors in cancer therapy: epigenetic modifiers
Akar, Remzi Okan; Selvi, Selin; Ulukaya, Engin; Aztopal, Nazlıhan (Tubitak Scientific & Technical Research Council Turkey, 2019)Epigenetic reprogramming plays a crucial role in the tumorigenicity and maintenance of tumor-specific gene expression that especially occurs through DNA methylation and/or histone modifications. It has well-defined mechanisms. ... -
A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells
Karakaş, Didem; Akar, Remzi Okan; Gökmen, Zeliha; Ulukaya, Engin; Deniz, Nahide Gülsah (TR- Dizin, 2019)Abstract: Breast cancer is the most-diagnosed cancer type among women. The triple-negative subtype is an especially aggressive type of breast cancer. Although chemotherapy is almost the only option for the treatment of ... -
A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex
Erkısa Genel, Merve; Aydınlık, Şeyma; Cevatemre, Buse; Aztopal, Nazlıhan; Akar, Remzi Okan; Çelikler, Serap; Yılmaz, Veysel Turan; Ari, Ferda; Ulukaya, Engin (Elsevier B.V., 2020)Autophagy is a catabolic process for cells that can provide energy sources and allows cancer cells to evade cell death. Therefore, studies on the combination of autophagy inhibitors with drugs are increasing as a new ... -
Synthesis, DNA binding and cytotoxic activity of newcopper(II) complexes of trisubstituted imidazoles
Gerçek, Zuhal; Yıldız, Ufuk; Ulukaya, Engin; Akar, Remzi Okan (Springer, 2022)This study was aimed to synthesize and characterize two new copper(II) complexes, [Cu(phen)(Br-impi)]2+ (1) and [Cu(phen)(M-impi)]2+ (2) (where phen is 1,10-phenanthroline; Br-impi is 2-(2-(4-bromophenyl)-4- (pyridin-2-y ...
