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Blood based biomarkers as predictive factors for hyperprogressive disease

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Date

2022

Author

Yildirim, Hasan Cagri
Guven, Deniz Can
Aktepe, Oktay Halit
Taban, Hakan
Yilmaz, Feride
Yasar, Serkan
Aksoy, Sercan
Erman, Mustafa
Kilickap, Saadettin
Yalcin, Suayib

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Citation

Yildirim, H. C., Guven, D. C., Aktepe, O. H., Taban, H., Yilmaz, F., Yasar, S., Aksoy, S., Erman, M., Kilickap, S., Yalcin, S. (2022). Blood based biomarkers as predictive factors for hyperprogressive disease. Journal of Clinical Medicine, 11(17).

Abstract

Purpose: With the widespread use of immunotherapy agents, we encounter treatment responses such as hyperprogression disease (HPD) that we have not seen with previous standard chemotherapy and targeted therapies. It is known that survival in patients with HPD is shorter than in patients without HPD. Therefore, it is important to know the factors that will predict HPD. We aimed to identify HPD-related factors in patients treated with immunotherapy. Methods: A total of 121 adult metastatic cancer patients treated with immunotherapy for any cancer were included. Baseline demographics, the ECOG performance status, type of tumors and baseline blood count parameters were recorded. Possible predisposing factors were evaluated with univariate and multivariate analyses. Results: The median age was 62.28 (interquartile range (IQR) 54.02-67.63) years, and the median follow-up was 12.26 (IQR 5.6-24.36) months. Renal cell carcinoma (33%) and melanoma (33.8%) were the most common diagnoses. Twenty patients (16.5%) had HPD. A high LDH level (p: 0.001), hypoalbuminemia (p: 0.016) and an NLR > 5 (p: 0.007) were found to be associated with hyperprogression. Sex (female vs. male, p: 0.114), age (>65 vs. <65, p: 0.772), ECOG (0 vs. 1-4, p: 0.480) and the line of treatment (1-5, p: 0.112) were not found to be associated with hyperprogression. Conclusions: In this study, we observed HPD in 16.5% of immunotherapy-treated patients and increased HPD risk in patients with a high LDH level (p: 0.001), hypoalbuminemia (p: 0.016) and an NLR > 5 (p: 0.007).

Source

JOURNAL OF CLINICAL MEDICINE

Volume

11

Issue

17

URI

https://doi.org/10.3390/jcm11175171
https://hdl.handle.net/20.500.12713/3163

Collections

  • Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu [367]
  • PubMed İndeksli Yayınlar Koleksiyonu [1162]
  • Scopus İndeksli Yayınlar Koleksiyonu [1924]
  • WoS İndeksli Yayınlar Koleksiyonu [2043]



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