RT-PCR cycle threshold (Ct) values predicting COVID-19 patients' outcome
Sonkaya, Muhammed Mert
Uluisik, Isilsu Ezgi
Demirel, Ozlem Unay
MetadataShow full item record
CitationIgnak, S., Yalcin, D., Cecen, O., Sonkaya, M. M., Uluisik, I. E., Demirel, O. U. (2022). RT-PCR cycle threshold (Ct) values predicting COVID-19 patients' outcome. Annals of Clinical and Analytical Medicine, 13(8), 882-886.
Aim: Clinical presentation of COVID-19 ranges from asymptomatic to fatal cases. Therefore, predictability of prognosis gains importance in managing the disease. The aim of this study is to investigate the relation between RT-PCR cycle threshold (Ct) values and the clinical severity of COVID-19 infection. Material and Methods: A retrospective study was conducted among 1224 COVID-19 patients. A scoring system, which is designed by the World Health Organization was used to classify patients by means of their clinical status. Results: The cut-off for Ct value in ROC curves was 21.52 at the point, when the COVID-19 patient clinic is shifting from ambulatory to hospitalized (79.7% sensitivity, 69% specificity). A significant weak positive correlation was found between age and WHO Score (r= .238 p<0.01) and a significant weak negative correlation was found between Ct value and WHO Score (r=-.068 p<0.05) in COVID-19 patients. Discussion: Patients with lower RT-PCR Ct values were more likely to go through the disease more severely due to higher virulence. Reporting of numerical Ct values may help clinicians in terms of prognosis.