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dc.contributor.authorGultekin, Alper
dc.contributor.authorAgirdil, Yucel
dc.contributor.authorDuman, Busra Oncel
dc.contributor.authorSubasi Demir, Cansu
dc.contributor.authorKaraoz, Erdal
dc.date.accessioned2020-08-30T20:06:18Z
dc.date.available2020-08-30T20:06:18Z
dc.date.issued2020
dc.identifier.citationGültekin, A., Ağirdil, Y., Duman, B. Ö., DEMİR, C. S., & Karaöz, E. (2020). Comparison of mesenchymal stem cell sheets and chondrocyte sheets in a rabbit growth plate injury model. Turkish journal of medical sciences, 50(4), 1082.en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://doi.org/10.3906/sag-1902-228
dc.identifier.urihttps://hdl.handle.net/20.500.12713/465
dc.description.abstractBackground/aim: The treatment of posttraumatic deformities and differences in length between the extremities resulting from physeal injury remains controversial. The aims of this study were to compare the efficacy of tissue-engineered, monolayer, and allogeneic mesenchymal stem cell sheets and chondrocyte sheets for physeal arrest treatment and to investigate cell sheet technology as a novel method for cell transplantation in physeal cartilage repair. Materials and methods: A proximal tibial physeal injury was induced in New Zealand rabbits. Allogeneic mesenchymal stem cells (MSCs) and chondrocytes were cultured in temperature-responsive culture dishes and applied to the iatrogenic partial growth plate defects in single-sheet grafts (cell sheets). Treatment efficacy was determined using radiological measurements, as well as histological and immunohistochemical staining. Results: Treatment with MSCs and chondrocytes prevented endochondral ossification in the physeal plate, and bone growth resumed after treatment in both the MSC and chondrocyte cell groups. We found significant differences in radiological evaluations between pre-and posttreatment measurements in both MSC and chondrocyte groups. Transplanted cells were observed in the damaged area in both of the groups, which differentiated in the direction of growth plate cartilage. Conclusion: Our results support the hypothesis that MSC or chondrocyte transplantation using the cell-sheet technique described in the present study aids in the regeneration of cartilage tissue during physeal arrest after growth plate damage.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAKARDEB) Research Support Programs Directorate; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114S152]en_US
dc.description.sponsorshipThe authors received funding from The Scientific and Technological Research Council of Turkey (TUBITAKARDEB) Research Support Programs Directorate. All financial support was provided by The Scientific and Technological Research Council of Turkey under the 3001 Starting R&D Projects Funding Programme (Project number: 114S152).en_US
dc.language.isoengen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.isversionof10.3906/sag-1902-228en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMesenchymal Stem Cellen_US
dc.subjectChondrocytesen_US
dc.subjectCell Sheeten_US
dc.subjectPhyseal Arresten_US
dc.titleComparison of mesenchymal stem cell sheets and chondrocyte sheets in a rabbit growth plate injury modelen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.authorID0000-0002-9992-833Xen_US
dc.contributor.institutionauthorKaraoz, Erdalen_US
dc.identifier.volume50en_US
dc.identifier.issue4en_US
dc.identifier.startpage1082en_US
dc.identifier.endpage1096en_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000549845300001en_US
dc.description.pubmedpublicationid32283887en_US
dc.description.wosqualityQ4en_US


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