Browsing PubMed İndeksli Yayınlar Koleksiyonu by Department "İstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü"
Now showing items 1-20 of 24
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Biallelic form of a known CD3E mutation in a patient with severe combined immunodeficiency
(Springer/Plenum Publishers, 2020)T cell receptor (TCR) complex consists of αβ or γδ TCR chains in combination with four CD3 subunits, CD3ε, CD3γ, CD3δ, and CDζ [1]. This complex is required for thymocyte development and the initiation of T cell-mediated ... -
Clinical and immunological features of 44 common variable immunodeficiency patients: The experience of a single center in Turkey
(Elsevier Doyma, 2020)Introduction and objectives: Common variable immunodeficiency (CVID) is one of the most prevalent forms of primary immunodeficiency characterized by hypogammaglobinemia. Its heterogeneous clinical features include recurrent ... -
Correction to: primary antibody deficiencies in Turkey: molecular and clinical aspects
(Springer, 2021)The original published version of this article contained a mistake in one of the affiliations. The correct affiliation of author Manolya Kara (7) should read: Istinye University Faculty of Medicine, VM MedicalPark Pendik ... -
Determining T and B Cell development by TREC/KREC analysis in primary immunodeficiency patients and healthy controls
(WILEY, 2022)T cell receptor excision circles (TRECs) and kappa-deleting excision circles (KRECs) are DNA fragments potentially indicative of T and B cell development, respectively. Recent thymic emigrants (RTEs) are a subset of ... -
Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy
(2022)A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and ... -
Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug-gene interaction networks analysis
(Nature, 2022)Lung cancer is the most common cancer in men and women. This cancer is divided into two main types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Around 85 to 90 percent of lung cancers are ... -
Dual suppressive effect of miR-34a on the FOXM1/eEF2-kinase axis regulates triple-negative breast cancer growth and invasion
(Amer Assoc Cancer Research, 2018)Purpose: Recent studies indicated that dysregulation of noncoding KNAs (ncRNA) such as miRNAs is involved in pathogenesis of various human cancers. However, the molecular mechanisms underlying miR-34a are not fully understood ... -
Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target
(Springer Heidelberg, 2020)Eukaryotic elongation factor-2 kinase (eEF2K), an atypical member of alpha-kinase family, is highly overexpressed in breast, pancreatic, brain, and lung cancers, and associated with poor survival in patients. eEF2K promotes ... -
Expanding the nude SCID/CID phenotype associated with FOXN1 homozygous, compound heterozygous, or heterozygous mutations
(Springer Link, 2021)Human nude SCID is a rare autosomal recessive inborn error of immunity (IEI) characterized by congenital athymia, alopecia, and nail dystrophy. Few cases have been reported to date. However, the recent introduction of ... -
Genetic screening of the patients with primary immunodeficiency by whole-exome sequencing
(New Rochelle, 2020)Background: Primary immunodeficiencies (PIDs) are a heterogeneous group of congenital disorders characterized by susceptibility to recurrent infections, allergy, malignancies and autoimmunity. The identification of ... -
IgE and IgG4 binding to lentil epitopes in children with red and green lentil allergy
(Wiley, 2020)Background The consumption of lentil is common in the Mediterranean area and is one of the causes of IgE-mediated food allergy in many countries. Len c 1 is a well-defined allergen of lentil and approximately 80% of the ... -
Impact of 5HydroxyMethylCytosine (5hmC) on reverse/direct association of cell-cycle, apoptosis, and extracellular matrix pathways in gastrointestinal cancers
(Springer, 2022)Background: Aberrant levels of 5-hydroxymethylcytosine (5-hmC) can lead to cancer progression. Identifcation of 5-hmC-related biological pathways in cancer studies can produce better understanding of gastrointestinal ... -
Invasive saprochaete capitata Infection in a patient with autosomal recessive CARD9 deficiency and a review of the literature
(Springer/Plenum Publishers, 2020)Purpose Autosomal recessive (AR) CARD9 deficiency is an inherited immune disorder which results in impaired innate immunity against various fungi. Superficial and invasive fungal infections, mainly caused by Candida or ... -
The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts
(Tubitak Scientific & Technical Research Council Turkey, 2017)The MTT assay is one of the often used cell viability/cytotoxicity assays. However, when the methanol extracts of plants are used to test their cytotoxic potential, interference may occur, resulting in false-positive ... -
Multi-organs-on-chips for testing small-molecule drugs: challenges and perspectives
(MDPI, 2021)Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate ... -
Mutational landscape of severe combined immunodeficiency patients from Turkey
(Wiley, 2020)Severe combined immunodeficiency (SCID) has a diverse genetic aetiology, where a clinical phenotype, caused by single and/or multiple gene variants, can give rise to multiple presentations. The advent of next-generation ... -
A novel foxn1 variant is identified in two siblings with nude severe combined immunodeficiency
(Springer/Plenum Publishers, 2019)Severe combined immunodeficiency (SCID) is the most severe form of primary immunodeficiencies (PIDs) caused by gene variants that lead to a failure of functional T cell development, with or without accompanying defects ... -
Primary antibody deficiencies in Turkey: molecular and clinical aspects
(Springer Link, 2021)Primary antibody deficiencies (PAD) are the most common subtype of primary immunodeficiencies, characterized by increased susceptibility to infections and autoimmunity, allergy, or malignancy predisposition. PAD syndromes ... -
Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia
(WILEY, 2021)Introduction: The lymphoid enhancer factor 1 (LEF1) is a DNA-binding transcription factor that functions in the Wnt signaling pathway. Increased LEF1 activity is associated with progression of several types of cancer ... -
Prognostic gene alterations and clonal changes in childhood B-ALL
(Pergamon-Elsevier Science Ltd, 2019)Genomic profiles of leukemia patients lead to characterization of variations that provide the molecular classification of risk groups, prediction of clinical outcome and therapeutic decisions. In this study, we examined ...
