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dc.contributor.authorGokmen, Zeliha
dc.contributor.authorOnan, Mehmet Erdi
dc.contributor.authorDeniz, Nahide Gulsah
dc.contributor.authorKarakas Zeybek, Didem
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:06:39Z
dc.date.available2020-08-30T20:06:39Z
dc.date.issued2019
dc.identifier.citationGokmen, Z., Onan, M. E., Deniz, N. G., Karakas, D., & Ulukaya, E. (2019). Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines. SYNTHETIC COMMUNICATIONS, 49(21), 3008–3016. https://doi.org/10.1080/00397911.2019.1655057en_US
dc.identifier.issn0039-7911
dc.identifier.issn1532-2432
dc.identifier.urihttps://doi.org/10.1080/00397911.2019.1655057
dc.identifier.urihttps://hdl.handle.net/20.500.12713/582
dc.description.abstract1,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this study, new N- and S,S-substituted-1,4-NQ derivatives were synthesized in excellent yields and were completely characterized by spectroscopic analysis IR, NMR (H-1 and C-13), MS and microanalysis. The cytotoxic activities of 1,4-NQ derivatives were examined against to A-549, DU145, HCT-116 and MDA-MB-231 cancer cells. Among these compounds, 2-[4-(2-furoyl)piperazine-1-yl]-3-chloro-1,4-NQ 5 and 2,3-bis(cyclobuthylsulfanyl)-1,4-NQ 17 were identified as the most potent anticancer agents with cytotoxic activity against three cell lines (breast (MDA-MB-231), prostate (DU145), colorectal (HCT-116).en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa [56964, FBA-2018-28971]en_US
dc.description.sponsorshipThis study was funded by Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa (Project number: 56964 and Project number: FBA-2018-28971).en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.isversionof10.1080/00397911.2019.1655057en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,4-Naphthoquinoneen_US
dc.subject1,4-Nqen_US
dc.subjectHeterocyclic Thioetheren_US
dc.subjectCytotoxicityen_US
dc.subjectAnticancer Agenten_US
dc.titleSynthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer linesen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Yazılım Mühendisliği Bölümüen_US
dc.contributor.authorID0000-0002-3781-6834en_US
dc.contributor.authorID0000-0003-4875-5472en_US
dc.contributor.institutionauthorKarakas Zeybek, Didemen_US
dc.contributor.institutionauthorUlukaya, Enginen_US
dc.identifier.volume49en_US
dc.identifier.issue21en_US
dc.identifier.startpage3008en_US
dc.identifier.endpage3016en_US
dc.relation.journalSynthetic Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000484035200001en_US
dc.description.wosqualityQ3en_US


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