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Cytotoxic and genotoxic effects of an endemic plant of Turkey salvia kronenburgii on breast cancer cell lines

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Date

2019

Author

Cebi, Aysegul
Akgun, Egemen
Celikler, Serap
Firat, Mehmet
Ozel, Mustafa Zafer
Ulukaya, Engin
Ari, Ferda

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Citation

Çebi, A., Akgün, E., Çelikler, S., Firat, M., Özel, M., Ulukaya, E., ... & Özel, M. Z. (2019). Cytotoxic and genotoxic effects of an endemic plant of Turkey on breast cancer cell lines. Journal of Cancer Research & Therapeutics, 15(5).

Abstract

Context: The natural products derived from plants are the important sources that can be used for breast cancer treatment. Salvia species and their derived products were recommended as potential antitumor substances. Aim: The potential cytotoxic and genotoxic effects of Salvia kronenburgii have been investigated on breast cancer cell lines, MCF-7 and MDA-MB-231. Materials and Methods: Determination of chemical compounds of S. kronenburgii was done using a gas chromatography coupled to time-of-flight mass spectrometry system and a dual-stage commercial thermal desorption injector. Growth inhibition of the S. kronenburgii was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ATP viability assays. The cell death mode was detected by fluorescent dyes. Genotoxic effect of S. kronenburgii was measured by comet assay. Results: S. kronenburgii showed antiproliferative effect in a dose-dependent manner on MCF-7 and MDA-MB-231 cell lines by inducing apoptosis-like cell death. The pyknotic cell nuclei were observed at the cell lines in response to S. kronenburgii. Furthermore, significant increase was shown in genetic damage index and frequencies in the damaged cells. Conclusion: S. kronenburgii might be a promising natural source for cancer therapy. Further experiments need to be done in vivo to understand of the anticancer effects of this plant.

Source

Journal of Cancer Research and Therapeutics

Volume

15

Issue

5

URI

https://doi.org/10.4103/jcrt.JCRT_1322_16
https://hdl.handle.net/20.500.12713/595

Collections

  • PubMed İndeksli Yayınlar Koleksiyonu [1153]
  • Scopus İndeksli Yayınlar Koleksiyonu [1892]
  • Temel Tıp Bilimleri Bölümü Makale Koleksiyonu [235]
  • WoS İndeksli Yayınlar Koleksiyonu [1965]



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