Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer
AuthorKarakas Zeybek, Didem
Berestein, G. L.
MetadataShow full item record
CitationZeybek, D. K., Kahraman, N., Bayraktar, R., Kabil, N., Ulukaya, E., Dere, E., & Ozpolat, B. (2019). Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer.
Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in cancer cells and its overexpression is correlated with poor prognosis in several types of cancer. It has been known that pancreatic cancer (PaCa) has a unique tumor microenvironment (TME) which contributes all stages of tumorigenesis. In this study, the effects of interaction between PaCa cells and macrophages on eEF2K levels and aggressive tumor behaviours were investigated.