Comparison of allogeneic stem cell transplantation results from related or unrelated donors in beta-thalassemia major

Abstract

Although there have been significant improvements with conventional therapies in beta thalassemia major, hematopoietic stem cell transplantation is only curative therapy. Related donors are preferred to diminish transplant risks. In lack of identical related donor, identical unrelated donors are second best choice. In this study, thalassemia major patients transplanted from unrelated donors (MUD) were compared with thalassemic patients transplanted from relative donor (MRD) retrospectively.