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dc.contributor.authorAkkaya, Enesen_US
dc.contributor.authorEvran, Sevketen_US
dc.contributor.authorCalis, Fatihen_US
dc.contributor.authorÇevik, Serdaren_US
dc.contributor.authorHanimoglu, Hakanen_US
dc.contributor.authorSeyithanoglu, Mehmet Hakanen_US
dc.contributor.authorKatar, Salimen_US
dc.contributor.authorKaratas, Ersinen_US
dc.contributor.authorKocyigit, Abdurrahimen_US
dc.contributor.authorSaglam, Mustafa Yasinen_US
dc.contributor.authorHatiboglu, Mustafa Azizen_US
dc.contributor.authorKaynar, Mehmet Yasaren_US
dc.date.accessioned2020-08-30T20:06:45Z
dc.date.available2020-08-30T20:06:45Z
dc.date.issued2019
dc.identifier.citationAkkaya, E., Evran, Ş., Çalış, F., Çevik, S., Hanımoğlu, H., Seyithanoğlu, M. H., ... & Hatiboğlu, M. A. (2019). Effects of Intrathecal Verapamil on Cerebral Vasospasm in Experimental Rat Study. World neurosurgery, 127, e1104-e1111.en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2019.04.050
dc.identifier.urihttps://hdl.handle.net/20.500.12713/612
dc.description16th World Congress of Neurosurgery of the World-Federation-of-Neurosurgical-Societies (WFNS) -- AUG 20-25, 2017 -- Istanbul, TURKEYen_US
dc.description.abstractBACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, Although the effective results of nimodipine and nicardipine's intrathecal administration are well known, intrathecal verapamil has not been considered earlier. We used an experimental subarachnoid hemorrhage induced vasospasm model for the evaluation of vasodilator and neuroprotective effects of intrathecal verapamil, METHODS: A total of 24 Sprague-Davvley rats were randomly divided into the following 3 groups: group 1 (sham), group 2 (subarachnoid hemorrhage), and group 3 {verapamil). A double hemorrhage method was used. Group 2 did not receive any treatment. Verapamil (Eporon, Hem Ilac, Turkey) at a dose of 1000 mu g/kg was given intrathecally to group 3 rats. The animals were euthanized on day 7 of the procedure. Arterial wall thickness and lumen diameter in the basilar arterial cross-sectional areas, endothelin-1 serum level, oxidative stress index, and apoptosis were measured in all groups. RESULTS: In the verapamil group, wall thickness, endothelin-1 level, oxidative stress index, and apoptosis were found to be significantly lower than the subarachnoid hemorrhage group, but the lumen diameter was found to be greater, Intrathecal verapamil was found to decrease vasospasm parameters and apoptosis and increase the antioxidant and antiapoptotic pathways. CONCLUSIONS: Our findings suggest that intrathecal verapamil can prevent vasospasnt oxidative stress, and apoptosis after experimental subarachnoid hemorrhage.en_US
dc.description.sponsorshipWorld Federat Neurosurg Socen_US
dc.description.sponsorshipBezmialem Vakif University FundBezmialem Vakif University [3.2015/40]en_US
dc.description.sponsorshipThis work was supported by the Bezmialem Vakif University Fund (Project Number: 3.2015/40).en_US
dc.language.isoengen_US
dc.publisherElsevier Science Incen_US
dc.relation.isversionof10.1016/j.wneu.2019.04.050en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAneurysmen_US
dc.subjectApoptosisen_US
dc.subjectEndothelin-1en_US
dc.subjectIntrathecal Verapamilen_US
dc.subjectOxidative Stressen_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.subjectVasospasmen_US
dc.titleEffects of intrathecai verapamil on cerebral vasospasm in experimental rat studyen_US
dc.typeconferenceObjecten_US
dc.contributor.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Anestezi Bölümüen_US
dc.contributor.institutionauthorÇevik, Serdaren_US
dc.identifier.volume127en_US
dc.identifier.startpageE1104en_US
dc.identifier.endpageE1111en_US
dc.relation.journalWorld Neurosurgeryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.contributor.wosauthoridSerdar Çevik / G-7161-2018
dc.contributor.scopusauthoridSerdar Çevik / 56516611400
dc.description.wospublicationidWOS:000473128300136en_US
dc.description.pubmedpublicationid30980985en_US
dc.description.wosqualityQ3en_US


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