Aggressive clinicopathological course of myeloma with t(3;16) (q21;q22) cytogenetic abnormality
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CitationBozkurt, S., Okay, M., & Haznedaroglu, I. (2019). Aggressive Clinicopathological Course of Myeloma with t (3; 16)(q21; q22) Cytogenetic Abnormality. Turk J Haematol, 36, 162-3.
Multiple myeloma (MM) is a heterogeneous disease and patients present with a wide variety of cytogenetic anomalies reflecting the nature of the disease . The aim of this letter is to report a rare karyotypic abnormality with an aggressive clinical course of MM. A 56-year-old male patient was admitted to the neurosurgery clinic with dorsal shoulder pain and inability to walk in April 2011. He underwent thoracic and lumbar spinal magnetic resonance imaging. Laminectomy was performed on the patient upon detecting masses at the levels of the first and seventh thoracic vertebrae. The patient was referred to our center when he was determined to have “lymphoma” based on the first evaluation 63 of his biopsy material. The specimen was then reevaluated in our center. A high-grade hematopoietic neoplasia was detected. Immunophenotypic findings suggested neoplasia with plasma cell origin. Immunohistochemically, neoplastic cells were positive for CD38, MUM-1, and kappa and negative for lambda. The karyotype of the patient was identified as 44,X,-Y,del(1) (p13p35),+der(1),t(3;16)(q21;q22),-4,-13,-14,+mar/46,XY (Figure 1).