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The effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case report

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Date

2018

Author

Okur, Sibel Caglar
Erdogan, Sinan
Subasi Demir, Cansu
Gunel, Gulsen
Karaoz, Erdal

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Citation

Okur, S. Ç., Erdoğan, S., Demir, C. S., Günel, G., & Karaöz, E. (2018). The effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case report. International journal of stem cells, 11(1), 141.

Abstract

Background: Cerebral Palsy (CP) is the most common motor disability reason of childhood that occurs secondarily to non-progressive damage in the brain whose development is still ongoing. Methods: 6-year-old dystonic-spastic male CP patient received allogenic mesenchymal stem cells treatment four times as 1x10(6)/kg in intrathecal and intravenous administration of Umbilical Cord-derived mesenchymal stem cells (UC-MSCs) ways. Before and after the treatment, the patient was followed-up with FIM (Functional Independent Measurement), GMFCS (Gross Motor Function Classification System 88), Tardieu Scale, TCMS (Trunk Control Measurement Scale), MACS (Manual Ability Classification Scale), CFSS (Communication Function Classification System) for 18 months and received intensive rehabilitation. Results: Improvements were observed especially in functional scales except for the Tardieu Scale, and no adverse effects were detected aside from a slight pain in the back. Conclusion: Wider future case studies on UC-MSCs will enable us to assess the efficacy of UC-MSCs which have positive impacts especially on functional scales.

Source

International Journal of Stem Cells

Volume

11

Issue

1

URI

https://doi.org/10.15283/ijsc17077
https://hdl.handle.net/20.500.12713/790

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