• Rusya’nın kürdoloji çalışmaları (1787-1947) 

  Ozdemir, Burcu; Askeroglu Arslan, Ayna (2018)

  Kafkaslar üzerinden Akdeniz’e inme planında Rusya karşısında Osman ve İran devletlerini bulmuş ancak karışık bir etnik yapıya sahip bu iki güçlü devletin içerisinde ilerlemek için etnik topluluklarla ilişki içerisine girmeyi ...

• Etoposide loaded SPION-PNIPAM nanoparticles improve the in vitro therapeutic outcome on metastatic prostate cancer cells via enhanced apoptosis 

  Erkisa Genel, Merve; Ari, Ferda; Ulku, Irem; Khodadust, Rouhollah; Yar, Yasemin; Acar, Havva Yagci; Ulukaya, Engin (2020)

  Prostate cancer is among the leading causes of death worldwide because its metastatic form is a deadly disease. Therefore, the development of new chemotherapeutics is of immense importance. Nanoparticle technology seems ...

• Desensitization in live kidney donor recipients provides good outcome at mid-term follow-up 

  Apaydin, Suheyla; Kasapoglu, Umut; Akbay, Fatih Gokhan; Kayalar, Arzu Ozdemir; Kudu, Aysegul; Dikec, Mehmet; Deger, Gunden; Toprak, Zeki; Carin, Mahmut Nezih (OXFORD UNIV PRESS, 2020)

  The recipients who have antibodies againts to donors’ HLA (Anti HLA- DSA) carrie a huge risk for allograf (AG) losing. In current study, it was retrospectively evaluated whether the live donor kidney recipients (LDKRs) ...

• A novel ganciclovir resistance mutation in the UL97 gene of the HHV-5 in an adult hematopoietic stem cell transplant recipient 

  Hancer, Veysel Sabri; Saglam Yarimcan, Filiz; Buyukdogan, Murat; Aki, Sahika Zeynep; Oksuz, Burcu; Acar, Kadir; Acar, Muradiye; Bulut, Pelin (Future Medicine Ltd, 2017)

  Therapeutic management of cytomegalovirus (CMV) disease in hematopoietic stem cell transplantation patients can become a challenge because of the emergence of anti-CMV drug resistance. This case report presents a patient ...

• Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells 

  Aztopal, Nazlihan; Erkisa Genel, Merve; Ertürk, Elif; Ulukaya, Engin; Tokullugil, Asuman Hatice; Ari, Ferda (Elsevier Ireland Ltd, 2018)

  Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...

• A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer 

  Cevatemre, Buse; Erkisa Genel, Merve; Aztopal, Nazlihan; Karakas Zeybek, Didem; Alper, Pinar; Tsimplouli, Chrisiida; Sereti, Evangelia; Dimas, Konstantinos; Armutak, Elif I. Ikitimur; Gurevin, Ebru Gurel; Uvez, Ayca; Mori, Mattia; Berardozzi, Simone; Ingallina, Cinzia; D'Acquarica, Ilaria; Botta, Bruno; Ozpolat, Bulent; Ulukaya, Engin (Academic Press Ltd- Elsevier Science Ltd, 2018)

  Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ...

• Dual inhibition of Wnt/beta-catenin signaling and histone deacetylation as a new strategy to eliminate breast cancer stem cells by augmentation of apoptosis 

  Aztopal, Nazlihan; Erkisa Genel, Merve; Ari, F.; Dere, E.; Ulukaya, Engin (Wiley, 2018)

  …

• Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA 

  Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Erkisa Genel, Merve; Turkdemir, Mehmet H.; Ulukaya, Engin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)

  A series of new Pt(II) saccharinate complexes containing PR3 ligands (PPh3, PPh2Cy, PPhCy2 and PCy3) with progressive phenyl (Ph) replacement by cyclohexyl (Cy) were synthesized and structurally characterized by lR, NMR, ...

• Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)-2,2:6,2-terpyridine with rigid dianionic 1,2,4-triazole-3-sulfonate linker 

  Buyukeksi, Sebile Isik; Erkisa Genel, Merve; Şengül, Abdurrahman; Ulukaya, Engin; Oral, Arzu Yilmaztepe (Wiley, 2018)

  A new dinuclear coordination compound of palladium(II), [Pd-2(terpy)(2)(-tas-N-1,N-4)]SO(4)11H(2)O (1), was synthesized by tethering a doubly deprotonated 1,2,4-triazole-3-sulfonate (tas) linker generated in situ via ...

• Palladium(II) and platinum(II) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells 

  Icsel, Ceyda; Yilmaz, Veysel T.; Aygun, Muhittin; Cevatemre, Buse; Alper, Pinar; Ulukaya, Engin (Royal Soc Chemistry, 2018)

  New neutral [M(sac)(2)(diphos)] and cationic [M(diphos)(2)](sac)(2) complexes, where M = Pd-II or Pt-II, sac = saccharinate, and diphos = 1,1-bis(diphenylphosphino)methane (dppm) or 1,2-bis(diphenylphosphino)ethane (dppe), ...

• \Prevalence of human papilloma virus types in Turkish and Albanian women 

  Hancer, Veysel Sabri; Buyukdogan, Murat; Bylykbashi, Ilta; Oksuz, Burcu; Acar, Muradiye (Wolters Kluwer Medknow Publications, 2018)

  Background: Human papilloma virus (HPV) infection is the major etiologic agent of cervical carcinoma. The aim of this study was to determine the prevalence of HPV infection and genotype distribution in cervical swabs from ...

• Pd(II) and Pt(II) saccharinate complexes of bis(diphenylphosphino) propane/butane: synthesis, structure, antiproliferative activity and mechanism of action 

  Yilmaz, Veysel T.; Icsel, Ceyda; Aygun, Muhittin; Erkisa Genel, Merve; Ulukaya, Engin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)

  [M(sac)(2)(dppp)] (1 and 2), [M(dppp)(2)](sac)(2) (3 and 4) and [M(sac)(2)(dppb)] (5 and 6) complexes, where M = Pd-II (1, 3 and 5) and Pt-II (2, 4 and 6), sac = saccharinate, dppp = 1,3-bis(diphenylphosphino)propane and ...

• Usnea filipendula induces apoptosis in human colon cancer cell lines 

  Disoma, C.; Erkisa, Merve; Oran, S.; Alioglu, I.; Ulukaya, Engin; Ari, F. (Wolters Kluwer Medknow Publications, 2018)

  Lichens are complex organisms living in a symbiotic relationship with fungi and algae have recently received special interest in cancer research. The cytotoxic activities of Usnea filipendula Stirt. lichen extract was ...

• Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect 

  Buz, Pelin Turhan; Duman, Fatma Demir; Erkisa Genel, Merve; Demirci, Gozde; Ari, Ferda; Ulukaya, Engin; Acar, Havva Yagci (Future Medicine Ltd, 2019)

  Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their ...

• Effective and new potent drug combination: histone deacetylase and Wnt/beta-catenin pathway inhibitors in lung carcinoma cells 

  Akgun, Oguzhan; Erkisa Genel, Merve; Ari, Ferda (Wiley, 2019)

  Lung cancer is the most commonly diagnosed cancer worldwide with a high mortality rate. In this study, the therapeutic effect of combination valproic acid and niclosamide was investigated on human lung cancer cell line. ...

• Synthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexes 

  Alper, Pinar; Erkisa Genel, Merve; Genckal, Hasene Mutlu; Sahin, Saliha; Ulukaya, Engin; Ari, Ferda (Elsevier, 2019)

  Flavonoids are natural products which are known to have biological activity for human health. In this study, new mixed ligand complexes of Ni(II) and Cu(II) were synthesized by using flavonoid (quercetin or naringenin) and ...

• Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity 

  Genckal, Hasene; Erkisa Genel, Merve; Alper, Pinar; Sahin, Saliha; Ulukaya, Engin; Ari, Ferda (Springer, 2020)

  In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2 '-bipyiridine) ligands. The obtained Ni(II) and Co(II) complexes are new and the ...

• Highly promising antitumor agent of a novel Platinum(II) complex bearing a tetradentate chelating ligand 

  Yilmaz, Ismail; Akar, Remzi Okan; Erkisa Genel, Merve; Selvi, Selin; Şengül, Abdurrahman; Ulukaya, Engin (Amer Chemical Soc, 2020)

  A new mononuclear cationic platinum(II) coordination compound with 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine (L) ligand having N-4-tetradentate binding pocket [Pt(L)]-Cl-2.2H(2)O (Complex 1) was synthesized and ...

• Cancer stem cells : root of the evil 

  Erkisa Genel, Merve; Karakas Zeybek, Didem; Ulukaya, Engin (Begell House Inc., 2019)

  Cancer stem cells (CSCs) have been one of the most attractive research areas over the last two decades due to their important roles in aggressive tumor behaviors. Although CSCs are usually a small subpopulation of tumors ...

• Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis 

  Ozturk, Sule; Erkisa Genel, Merve; Oran, Oran; Ulukaya, Engin; Celikler, Serap; Ari, Ferda (Taylor and Francis Ltd, 2019)

  Successful cancer treatment still requires new complexes or compounds from natural sources. Therefore, we investigated anti-growth/apoptotic effects of methanol extracts of the lichen species (Xanthoparmelia somloensis ...

View more