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dc.contributor.authorYilmaz, Mucahid
dc.contributor.authorKayancicek, Hidayet
dc.date.accessioned2020-08-30T20:07:37Z
dc.date.available2020-08-30T20:07:37Z
dc.date.issued2018
dc.identifier.citationYilmaz, M., & Kayancicek, H. (2018). A New Inflammatory Marker: Elevated Monocyte to HDL Cholesterol Ratio Associated with Smoking. JOURNAL OF CLINICAL MEDICINE, 7(4). https://doi.org/10.3390/jcm7040076en_US
dc.identifier.issn2077-0383
dc.identifier.urihttps://doi.org/10.3390/jcm7040076
dc.identifier.urihttps://hdl.handle.net/20.500.12713/800
dc.descriptionYILMAZ, MUCAHID/0000-0003-1458-8637en_US
dc.descriptionWOS: 000435182400017en_US
dc.descriptionPubMed: 29642607en_US
dc.description.abstractObjectives: The adverse effects of smoking in various pathologies are mediated by its effects on the inflammatory system. The monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) has recently emerged as an indicator of inflammation. We aimed to investigate the relationship between MHR and cigarette smoking. Patients and Methods: Three hundred and ninety seven consecutive participants who smoke and 515 healthy subjects with no history of smoking enrolled in the study. Complete blood count parameters and lipid profile were analyzed in all study participants. Smoking habits were calculated as pack. years and number of cigarettes smoked per day. Results: MHR levels were significantly higher in smokers compared to non-smokers (respectively, 15.71 (12.02-20.00) and 11.17 (8.50-14.16), p < 0.0001)). Pearson's correlation analysis revealed a weak but positive correlation between pack. year and MHR in the smokers group, and there was a moderate positive correlation between the number of cigarettes smoked daily and MHR in the group. In receiver operating characteristics (ROC) analyses, it was determined that a MHR value >13.00 measured in smoker participants at application had a predictive specificity of 66.6% and sensitivity of 70.0% for smoking (area under the curve [AUC] 0.729, 95% CI 0.696, 0.762; p < 0.0001). Conclusions: Elevated MHR is associated with cigarette smoking and may be a useful indicator of a systemic inflammatory response in smokers. Smoker participants who have high MHR levels can easily be identified during routine complete blood count (CBC) analysis and could possibly benefit from preventive treatment.en_US
dc.language.isoengen_US
dc.publisherMdpien_US
dc.relation.isversionof10.3390/jcm7040076en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSmokingen_US
dc.subjectMonocyte To High-Density Lipoprotein Cholesterolen_US
dc.subjectInflammationen_US
dc.titleA new inflammatory marker: elevated monocyte to hdl cholesterol ratio associated with smokingen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Hastaneen_US
dc.contributor.institutionauthorKayancicek, Hidayeten_US
dc.identifier.volume7en_US
dc.identifier.issue4en_US
dc.relation.journalJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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