• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace@İSÜ
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed | DergiPark
  • WoS İndeksli Yayınlar Koleksiyonu
  • View Item
  •   DSpace@İSÜ
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed | DergiPark
  • WoS İndeksli Yayınlar Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Current strategies and future perspectives of skin-on-a-chip platforms: innovations, technical challenges and commercial outlook

Thumbnail

View/Open

Tam Metin / Full Text (4.164Mb)

Date

2018

Author

Bal-Ozturk, Ayca
Miccoli, Beatrice
Avci-Adali, Meltem
Mogtader, Ferzaneh
Sharifi, Fatemeh
Cecen, Berivan
Yasayan, Gokcen
Braeken, Dries
Alarcin, Emine

Metadata

Show full item record

Citation

Bal-Öztürk, A., Miccoli, B., Avci-Adali, M., Mogtader, F., Sharifi, F., Çeçen, B., ... & Alarcin, E. (2018). Current Strategies and Future Perspectives of Skin-on-a-Chip Platforms: Innovations, Technical Challenges and Commercial Outlook. Current pharmaceutical design, 24(45), 5437-5457.

Abstract

The skin is the largest and most exposed organ in the human body. Not only it is involved in numerous biological processes essential for life but also it represents a significant endpoint for the application of pharmaceuticals. The area of in vitro skin tissue engineering has been progressing extensively in recent years. Advanced in vitro human skin models strongly impact the discovery of new drugs thanks to the enhanced screening efficiency and reliability. Nowadays, animal models are largely employed at the preclinical stage of new pharmaceutical compounds development for both risk assessment evaluation and pharmacokinetic studies. On the other hand, animal models often insufficiently foresee the human reaction due to the variations in skin immunity and physiology. Skin-on-chips devices offer innovative and state-of-the-art platforms essential to overcome these limitations. In the present review, we focus on the contribution of skin-on-chip platforms in fundamental research and applied medical research. In addition, we also highlighted the technical and practical difficulties that must be overcome to enhance skin-on-chip platforms, e. g. embedding electrical measurements, for improved modeling of human diseases as well as of new drug discovery and development.

Source

Current Pharmaceutical Design

Volume

24

Issue

45

URI

https://doi.org/10.2174/1381612825666190206195304
https://hdl.handle.net/20.500.12713/821

Collections

  • Makale Koleksiyonu [40]
  • PubMed İndeksli Yayınlar Koleksiyonu [877]
  • Scopus İndeksli Yayınlar Koleksiyonu [1259]
  • WoS İndeksli Yayınlar Koleksiyonu [1313]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Instruction | Guide | Contact |

DSpace@İSÜ

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeInstitution AuthorThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeInstitution Author

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Guide|| Instruction || Library || İstinye University || OAI-PMH ||

İstinye University, İstanbul, Turkey
If you find any errors in content, please contact:

Creative Commons License
İstinye University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@İSÜ:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.