Role of caspase-9 gene Ex5+32 G > A (rs1052576) variant in susceptibility to primary brain tumors
Yilmaz, Seda Gulec
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CitationOzdogan, S., Kafadar, A., Yilmaz, S. G., Timirci-Kahraman, O., Gormus, U., & Isbir, T. (2017). Role of Caspase-9 Gene Ex5+ 32 G> A (rs1052576) Variant in Susceptibility to Primary Brain Tumors. Anticancer Research, 37(9), 4997-5000.
Background/Aim: This study is the first to evaluate the relationship of caspase-9 (CASP-9) gene polymorphism with the risk for primary brain tumor development. Materials and Methods: The study group included 43 glioma and 27 meningioma patients and 76 healthy individuals. CASP-9 gene Ex5+32 G>A (rs1052576) polymorphism was analyzed by real-time polymerase chain reaction (RT-PCR). Results: Individuals with the CASP-9 GG genotype had significantly decreased risk of developing a glioma brain tumor (p=0.024). Additionally, the GA genotype was significantly lower in patients with glioma than the control group (p=0.019). A significantly decreased risk of developing glioma was found in the A allele carrier group (p=0.024). However, there was no statistically significant relationship between CASP-9 polymorphism and brain meningioma (p=0.493). Conclusion: CASP-9 (rs1052576) mutant A allele seems to be a protective factor for glioma brain tumor. Future studies with a larger sample size will clarify the possible roles of CASP-9 gene in the etiology and progression of primary brain tumors.