SCARB1 gene polymorphisms and HDL subfractions in coronary artery disease
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CitationAyhan, H., Gormus, U., Isbir, S., Yilmaz, S. G., & Isbir, T. (2017). SCARB1 gene polymorphisms and HDL subfractions in coronary artery disease. In Vivo, 31(5), 873–876. https://doi.org/10.21873/invivo.11141
Background/Aim: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Polymorphisms in the SCARB1 gene are known to be related to plasma lipids. Patients and Methods: Real time-polymerase chain reaction (RT-PCR) was used for identification of SCARB1 polymorphisms and the Lipoprint Quantimetrix System was employed in identification of HDL subfractions. Results: According to allelic distribution, in both groups SCARB1 AA genotype led to a two-fold decrease in the risk of developing cardiovascular disease (p=0.04), while the GA genotype increased the risk two-fold (p=0.03). According to the HDL subfraction analysis results, the AA genotype had higher levels of big-sized HDL subfraction (p=0.02). Conclusion: The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL subfraction.