Effects of VEGF plus adipose tissue derived mesenchymal stem cells with platelet rich plasma on inbred rat ovarian functions in premature ovarian insufficiency model

Abstract

What is known already: Numerous studies have found an increased risk of congenital malformations among live-born children conceived after assisted reproduction compared with spontaneously conceivedchildren. The underlying subfertility matters, as children born by couples taking a long time to conceive spontaneously also have an increased risk of congenital malformations. Still the assisted reproductive technology may also play a role. Little is known concerning the prenatal detection rate of fetal malformations in pregnancies conceived after assisted reproduction and it is unclear if women pregnant after assisted reproduction are more or less likely to terminate a pregnancy due to a fetal malformation.