Relationship between MCP1 (-2518A > G) gene variants and ovarian cancer in Turkish population
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CitationAttar, R., Yilmaz, S. G., Çakmakoglu, B., Duman, S., Yildirim, G., Görmüs, U., & Isbir, T. (2017). Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish population. Cellular and Molecular Biology, 63(8), 100–103. https://doi.org/10.14715/cmb/2017.63.8.21
The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52). There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; x(2)=6.042). AA carriers were significantly higher in the control group (p=0.014) whereas AG genotype and G allele carriers were significantly higher in the ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer.