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dc.contributor.authorMoralioglu, Serdar
dc.contributor.authorVural, Ismail Mert
dc.contributor.authorOzen, Ibrahim Onur
dc.contributor.authorOzturk, Gokce
dc.contributor.authorSarioglu, Yusuf
dc.contributor.authorBasaklar, Abdullah Can
dc.date.accessioned2020-08-30T20:08:21Z
dc.date.available2020-08-30T20:08:21Z
dc.date.issued2017
dc.identifier.citationMoralıoğlu, S., Vural, İ. M., Özen, İ. O., Öztürk, G., Sarıoğlu, Y., & Başaklar, A. C. (2017). Changes in cholinergic and nitrergic systems of defunctionalized colons after colostomy in rabbits. Journal of Surgical Research, 207, 63-69.en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.urihttps://doi.org/10.1016/j.jss.2016.08.032
dc.identifier.urihttps://hdl.handle.net/20.500.12713/924
dc.descriptionSARIOGLU, YUSUF/0000-0002-9227-365Xen_US
dc.descriptionWOS: 000392212800009en_US
dc.descriptionPubMed: 27979489en_US
dc.descriptionSarioglu, Yusuf (isu author)
dc.description.abstractBackground: This study was designed to assess smooth muscle function and motility in defunctionalized colonic segments and subsequent changes in pathways responsible for gastrointestinal motility. Methods: Two-month-old New Zealand rabbits were randomly allocated into control and study groups. Sigmoid colostomies were performed in the study group. After a 2-month waiting period, colonic segments were harvested in both groups. For the in vitro experiment, the isolated circular muscle strips which were prepared from the harvested distal colon were used. First, contraction responses were detected using KCl and carbachol; relaxation responses were detected using papaverine, sodium nitroprusside, sildenafil, and L-arginine. The neurologic responses of muscle strips to electrical field stimulation (EFS) were evaluated in an environment with guanethidine and indomethacin. EFS studies were then repeated with atropine, Nu-nitro-L-arginine methyl ester, atropine, and Nu-nitro-Larginine methyl estereadded environments. Results: Although macroscopic atrophy had developed in the distal colonic segment of the colostomy, the contraction and relaxation capacity of the smooth muscle did not change. EFS-induced nitrergic-peptidergic, cholinergic-peptidergic, and noncholinergic nonnitrergic responses significantly decreased at all frequencies (0.5-32 Hz) in the study group compared with those in the control group (P < 0.05). Conclusions: Although the contraction capacity of the smooth muscle was not affected, the motility of the distal colon deteriorated owing to the defective secretion of presynaptic neurotransmitters such as acetylcholine, nitric oxide, and neuropeptides. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipGazi University Research FoundationGazi University [01/2007-25]en_US
dc.description.sponsorshipThis study was supported by Gazi University Research Foundation (01/2007-25).en_US
dc.language.isoengen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.isversionof10.1016/j.jss.2016.08.032en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiversion Colostomyen_US
dc.subjectEnteric Nervous Systemen_US
dc.subjectCholinergic Systemen_US
dc.subjectNitrergic Systemen_US
dc.subjectRabbiten_US
dc.titleChanges in cholinergic and nitrergic systems of defunctionalized colons after colostomy in rabbitsen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.authorID0000-0002-9227-365Xen_US
dc.contributor.institutionauthorSarioglu, Yusufen_US
dc.identifier.volume207en_US
dc.identifier.startpage63en_US
dc.identifier.endpage69en_US
dc.relation.journalJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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