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dc.contributor.authorOzdemir, Alper Tunga
dc.contributor.authorOzdemir, Rabia Bilge Ozgul
dc.contributor.authorKirmaz, Cengiz
dc.contributor.authorSariboyaci, Ayla Eker
dc.contributor.authorHalbutogllari, Zehra Seda Unal
dc.contributor.authorOzel, Ceren
dc.contributor.authorKaraoz, Erdal
dc.date.accessioned2020-08-30T20:08:22Z
dc.date.available2020-08-30T20:08:22Z
dc.date.issued2016
dc.identifier.citationOzdemir, A. T., Ozdemir, R. B. O., Kirmaz, C., Sariboyaci, A. E., Halbutogllari, Z. S. U., Ozel, C., & Karaoz, E. (2016). The paracrine immunomodulatory interactions between the human dental pulp derived mesenchymal stem cells and CD4 T cell subsets. CELLULAR IMMUNOLOGY, 310, 108–115. https://doi.org/10.1016/j.cellimm.2016.08.008en_US
dc.identifier.issn0008-8749
dc.identifier.issn1090-2163
dc.identifier.urihttps://doi.org/10.1016/j.cellimm.2016.08.008
dc.identifier.urihttps://hdl.handle.net/20.500.12713/926
dc.descriptionAT, Ozdemir/0000-0002-7708-077X; Sariboyaci, Ayla Eker/0000-0003-4536-9859; Ozgul Ozdemir, Rabia Bilge/0000-0002-8171-3402en_US
dc.descriptionWOS: 000388823700011en_US
dc.descriptionPubMed: 27576175en_US
dc.descriptionKaraoz, Erdal (isu author)
dc.description.abstractMesenchymal stem cells (MSCs) have strong immunomodulatory properties, however these properties may show some differences according to the tissue type of their isolate. In this study we investigated the paracrine interactions between human DP derived MSCs (hDP-MSCs) and the CD4(+) T helper cell subsets to establish their immunomodulatory mechanisms. We found that the CD4(+)-Tbet(+) (Th1) and CD4(+)-Gata3(+) (Th2) cells were suppressed by the hDP-MSCs, but the CD4(+)-Stat3(+) (Th17) and CD4(+)-CD25(+)-FoxP3(+) (Treg) cells were stimulated. The expressions of T cell specific cytokines interferon gamma (IFN-g), interleukin (IL)-4 and IL-17a decreased, but IL-10 and transforming growth factor beta-1 (TGF-b1) increased with the hDP-MSCs. The expressions of indoleamine-pyrrole 2,3-dioxygenase (IDO), prostaglandin E2 (PGE2), soluble human leukocyte antigen G (sHLA-G) derived from hDP-MSCs slightly increased, but hepatocyte growth factor (HGF) significantly increased in the co-culture groups. According to our findings, the hDP-MSCs can suppress the Th1 and Th2 subsets but stimulate the Th17 and Treg subsets. The Stat3 expression of Th17 cells may have been stimulated by the HGF, and thus the pro-inflammatory Th17 cells may have altered into the immunosuppressive regulatory Th17 cells. Further prospective studies are needed to confirm our findings. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Commission of Celal Bayar UniversityCelal Bayar University [2013/136]en_US
dc.description.sponsorshipThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. The Scientific Research Projects Commission of Celal Bayar University supported the project for this study, whose reference number is 2013/136.en_US
dc.language.isoengen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.isversionof10.1016/j.cellimm.2016.08.008en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMesenchymal Stem Cellen_US
dc.subjectCD4 T Cellen_US
dc.subjectImmunomodulationen_US
dc.subjectInterleukinen_US
dc.subjectHepatocyte Growth Factoren_US
dc.subjectStat3en_US
dc.subjectFoxp3en_US
dc.subjectT-Beten_US
dc.subjectGata3en_US
dc.titleThe paracrine immunomodulatory interactions between the human dental pulp derived mesenchymal stem cells and CD4 T cell subsetsen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.authorID0000-0002-9992-833Xen_US
dc.contributor.institutionauthorKaraoz, Erdalen_US
dc.identifier.volume310en_US
dc.identifier.startpage108en_US
dc.identifier.endpage115en_US
dc.relation.journalCellular Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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