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    Does blood pressure variability affect hypertension development in pre-hypertensive patients?
    (Oxford Academic, 2021) Özkan, Gülsüm; Ulusoy, Şükrü; Arıcı, Mustafa; Derici, Ülver; Akpolat, Tekin; Şengül, Şule
    Background: Blood pressure variability (BPV) is associated with end organ damage and cardiovascular outcomes in hypertensive patients. Pre-hypertensive patients frequently develop hypertension (HT). The purpose of the present study was to evaluate the effect of BPV on the development of HT. Methods: Two hundred seven pre-hypertensive patients from the Cappadocia cohort were monitored over two years, and 24-h ambulatory blood pressure monitoring (24-h ABPM), office and home BP measurements were subsequently performed at four to six-month intervals. BPV was calculated as average real variability (ARV) from 24-h ABPM data, home and office BP measurements at first visit. The relationship was evaluated between baseline ARV and the development of HT. Results: HT was diagnosed in 25.60% of subjects. Baseline 24-h ABPM systolic blood pressure (SBP)ARV and diastolic blood pressure (DBP)ARV and home SBP ARV were significantly higher in patients who developed HT than the other patients (p 0.006, 0.001 and 0.006, respectively). Baseline 24h-ABPM SBPARV and home SBPARV exceeding the 90 th percentile were identified as parameters affecting development of HT at logistic regression analysis. Conclusion: In conclusion, our prospective observational cohort study showed that short-term BPV in particular can predict the development of HT in the pre-hypertensive population.
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    Which out-of-office measurement technique should be used for diagnosing hypertension in prehypertensives?
    (Nature Publishing Group, 2020) Ulusoy, Şükrü; Özkan, Gülsüm; Arıcı, Mustafa; Derici, Ülver; Akpolat, Tekin; Şengül, Şule; Yılmaz, Rahmi; Ertürk, Şehsuvar; Erdem, Yunus
    Hypertension (HT) is diagnosed with high office blood pressure (BP), although confirmation with the addition of out-of-office measurements is currently recommended. However, insufficient data are available concerning the use of out-of-office BP measurement techniques for the diagnosis of HT in the prehypertensive population. The aim of the present study was to determine which out-of-office measurements yielded earlier and more frequent detection of development of HT in prehypertensive patients. Two hundred seven prehypertensive patients under monitoring in the Cappadocia cohort were included in the study. Office BP was measured five times at 1-min intervals, followed by 24-h ambulatory BP monitoring (24-h ABPM). Home BP measurement (HBPM) was performed five times, at the same times in the morning and evening, at 1-min intervals for 1 week. The same procedure was carried out at 4-6-month intervals for ~2 years. HT was diagnosed in 25.6% of subjects, masked HT in 11.1%, and white coat HT in 2.9%, while 23.7% remained prehypertensive and 36.7% became normotensive. Briefly, 56.6% of the patients with HT were diagnosed with office plus 24-h ABPM, 13.2% with office plus HBPM, and 30.2% with office plus HBPM and 24-h ABPM. Office with 24-h ABPM yielded statistically significantly more diagnoses (p < 0.001). In conclusion, our prospective observational study evaluated the usefulness of out-of-office BP measurements in confirming diagnosis of HT in prehypertensive patients. The findings show that 24-h ABPM detected HT earlier and more frequently in this high-risk population.