Yazar "Aksu, Serkan" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder(Springer Heidelberg, 2019) Soyata, Ahmet Zihni; Aksu, Serkan; Woods, Adam J.; İşcen, Pınar; Saçar, Kardelen Türkü; Karamürsel, SacitDecision making and cognitive flexibility are two components of cognitive control that play a critical role in the emergence, persistence, and relapse of gambling disorder. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been reported to enhance decision making and cognitive flexibility in healthy volunteers and individuals with addictive disorders. In this triple-blind randomized sham-controlled parallel study, we aimed to determine whether tDCS over DLPFC would modulate decision making and cognitive flexibility in individuals with gambling disorder. Twenty participants with gambling disorder were administered Iowa Gambling Task (IGT) and Wisconsin Card Sorting Test (WCST). Subsequently, participants were administered three every other day sessions of active right anodal/left cathodal tDCS (20 min, 2 mA) or sham stimulation over bilateral DLPFC. WCST and IGT were readministered following the last session. Baseline clinical severity, depression, impulsivity levels, and cognitive performance were similar between groups. TDCS over the DLPFC resulted in more advantageous decision making (F-1,F-16 = 8.128, p = 0.01, eta p(2) = 0.33) and better cognitive flexibility (F-1,F-16 = 8.782, p = 0.009, eta p(2) = 0.35), representing large effect sizes. The results suggest for the first time that tDCS enhanced decision making and cognitive flexibility in gambling disorder. Therefore, tDCS may be a promising neuromodulation-based therapeutic approach in gambling disorder.Öğe Efficacy and mechanisms of transcranial electrical stimulation in headache disorders(Ege Univ, 2019) Şirin, Tuba Cerrahoğlu; Aksu, Serkan; Kurt, Adnan; Karamürsel, Sacit; Baykan, BetülHeadache is the one of the most common problems contributing to suffering worldwide and sometimes it causes disability. Some patients are unable to use the drugs for various reasons and some are resistant to the pharmacological treatment. Therefore, additional effective non-pharmacological treatments are sought.Transcranial electrical stimulation techniques have been developed as potential therapeutic options. Among these techniques, transcranial direct current stimulation (tDCS) is the only technique studied for the treatment of headache. TDCS is a neurophysiological technique with multifarious advantages encompassing its low-cost, high tolerability and acceptability, comfortable application and the opportunity to use concomitantly with other treatments. Steadily increasing interest in tDCS stems from the multidisciplinary advances in neuroscientific backgrounds of neuropsychiatric diseases. Even though exact mechanisms behind benefits of tDCS have not yet been clearly disclosed, changes in multitudinous chemical and physiological parameters have been demonstrated. The purpose of this review is to summarize what is currently known regarding the effects of tDCS on the treatment of headache focusing mostly on migraine. Herein, tDCS procedures that may be helpful for primary headache treatment were described. TDCS has shown promise for effectively treating primary headaches with no severe adverse effects. The findings indicate that the analgesic effects of tDCS can last for a long period and can occur after the time of stimulation. Additional research is required for the determination of optimized stimulation protocols in each specific headache disorder.Öğe Elektroretinografi ve görsel uyarılmış potansiyel ölçümlerinde zenon ve led ışık kaynaklarının karşılaştırılması(2019) Aksu, Serkan; Kurt, Adnan; Soyata, Ahmet Zihni; Sacar, Kardelen Turku; Taşdelen, Semih; Karamürsel, SacitAmaç: Elektroretinografi (ERG) ve görsel uyarılmış potansiyeller (GUP) görsel bir uyarana yanıt olarak retinada veya oksipital korteksteki primer görme alanında oluşan elektriksel etkinliği ölçen ve görme yollarını nesnel olarak değerlendiren önemli tanı araçlarıdır. Elektriksel potansiyellerin oluşturulması için zenon ya da ışık yayan diyot (LED) ışık kaynağı kullanılabilmektedir. Her iki ışık kaynağı da kullanılarak ölçülen ERG ve GUP kayıtlarını aynı örneklemde karşılaştıran bir araştırmaya rastlanmadığı için, bu çalışmada sağlıklı gönüllülerde zenon ve LED ışık kaynağı kullanılarak oluşturulan ERG ve GUP ölçümlerini karşılaştırmak amaçlanmıştır. Gereç ve Yöntemler: Araştırmanın örneklemi 21–30 yaş aralığındaki 31 sağlıklı gönüllüden oluşmuştur. LED ve zenon ışık kaynağı ile her iki gözden ayrı ayrı ERG ve GUP kayıtları alındı. ERG kayıtlarındaki “a,” “b,” ve GUP kayıtlarındaki N2, P2 dalgalarının gecikme süreleri ve genlikleri eşleştirilmiş t-testiyle karşılaştırıldı. Bulgular: LED ışık kaynağıyla elde edilen ERG kayıtlarında zenon ışık kaynağıyla elde edilen kayıtlara göre a (p<0,001) ve b (p<0,001) dalgalarının genlikleri daha düşük bulundu. LED ışık kaynağı ile elde edilen GUP kayıtlarında ise zenon ışık kaynağı ile elde edilen kayıtlara göre P2 dalgasının genliği (p<0,001) daha düşük bulundu. Ancak her iki ışık kaynağı ile elde edilen ERG ve GUP kayıtlarındaki gecikme süreleri arasında fark saptanmadı. Tartışma ve Sonuç: LED ışık kaynağı ile elde edilen ERG ve GUP kayıtlarının, zenon lamba ile elde edilenlere büyük ölçüde benzer bir dalga morfolojisine sahip olduğu görülmüştür. Ancak bazı dalgalarda daha düşük genlikler elde edilmiştir ve bu durumun görme bozukluklarının saptanmasındaki duyarlılık ve özgüllüğünün azalmasına neden olabileceği düşünülmüştür. LED ışık kaynağı ile yapılan GUP ve ERG ölçümlerindeki genlikleri artırmak için monokromatik LED ve özel gözlük kullanılması gibi değişiklikler önerilebilir.Öğe Evaluation of neurotoxicity of multiple anesthesia in children using visual evoked potentials(Kare Publ, 2019) Oba, Sibel; Işıl, Canan Tüley; Türk, Hacer Şebnem; Karamürsel, Sacit; Aksu, Serkan; Kaba, Meltem; Dokucu, Ali İhsanObjectives: Anesthetic applications may cause increased neuronal damage in infants and children. Commonly cognitive or learning disability tests were used to investigate the neurological progress in children. Visual Evoked Potential is a gross electrical signal generated by the occipital regions of the cerebral cortex in response to visual stimulation and an objective assessment of brain function. In this study, to acquire more objective results, Visual Evoked Potential responses of children who had multiple exposures to anesthesia during the treatment of corrosive esophagitis were compared to children who have never received anesthesia before. Methods: In this prospective, single-blinded, randomized, controlled study, 25 children, who were admitted to our pediatric surgery clinic because of corrosive esophagitis and who received general anesthesia more than 15 times composed Group-P; 25 children, who admitted to our well-child-clinic and who had never received anesthesia before consisted Group-C. The flash and pattern VEP responses of both groups were measured at the electrophysiology laboratory without any anesthetic drug application. The VEP responses of children in Group-P were recorded at least three days after the last exposure to anesthesia. Results: Latencies and amplitudes of the N2 and P2 components of the pattern and flash VEP responses were statistically significantly different between the two groups (p=0.000). Conclusion: This study shows that in children who had repeated anesthetic applications VEP parameters are significantly altered. We believe that VEP responses may be a reliable objective criterion for the evaluation of anesthesia neurotoxicity.