Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Heidelberg
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Decision making and cognitive flexibility are two components of cognitive control that play a critical role in the emergence, persistence, and relapse of gambling disorder. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been reported to enhance decision making and cognitive flexibility in healthy volunteers and individuals with addictive disorders. In this triple-blind randomized sham-controlled parallel study, we aimed to determine whether tDCS over DLPFC would modulate decision making and cognitive flexibility in individuals with gambling disorder. Twenty participants with gambling disorder were administered Iowa Gambling Task (IGT) and Wisconsin Card Sorting Test (WCST). Subsequently, participants were administered three every other day sessions of active right anodal/left cathodal tDCS (20 min, 2 mA) or sham stimulation over bilateral DLPFC. WCST and IGT were readministered following the last session. Baseline clinical severity, depression, impulsivity levels, and cognitive performance were similar between groups. TDCS over the DLPFC resulted in more advantageous decision making (F-1,F-16 = 8.128, p = 0.01, eta p(2) = 0.33) and better cognitive flexibility (F-1,F-16 = 8.782, p = 0.009, eta p(2) = 0.35), representing large effect sizes. The results suggest for the first time that tDCS enhanced decision making and cognitive flexibility in gambling disorder. Therefore, tDCS may be a promising neuromodulation-based therapeutic approach in gambling disorder.
Açıklama
Anahtar Kelimeler
Addictive Disorders, Gambling Disorder, Transcranial Direct Current Stimulation, Decision Making, Executive Functions, Cognitive Functions
Kaynak
European Archives of Psychiatry and Clinical Neuroscience
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
269
Sayı
3
Künye
Soyata, A. Z., Aksu, S., Woods, A. J., İşçen, P., Saçar, K. T., & Karamürsel, S. (2019). Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder. European archives of psychiatry and clinical neuroscience, 269(3), 275-284.
