Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder

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dc.authoridSacit Karamürsel / 0000-0002-7534-9392
dc.authorscopusidSacit Karamürsel / 7004361830
dc.authorwosidSacit Karamürsel / O-9371-2019
dc.contributor.authorSoyata, Ahmet Zihni
dc.contributor.authorAksu, Serkan
dc.contributor.authorWoods, Adam J.
dc.contributor.authorİşcen, Pınar
dc.contributor.authorSaçar, Kardelen Türkü
dc.contributor.authorKaramürsel, Sacit
dc.date.accessioned2020-08-30T20:06:52Z
dc.date.available2020-08-30T20:06:52Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractDecision making and cognitive flexibility are two components of cognitive control that play a critical role in the emergence, persistence, and relapse of gambling disorder. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been reported to enhance decision making and cognitive flexibility in healthy volunteers and individuals with addictive disorders. In this triple-blind randomized sham-controlled parallel study, we aimed to determine whether tDCS over DLPFC would modulate decision making and cognitive flexibility in individuals with gambling disorder. Twenty participants with gambling disorder were administered Iowa Gambling Task (IGT) and Wisconsin Card Sorting Test (WCST). Subsequently, participants were administered three every other day sessions of active right anodal/left cathodal tDCS (20 min, 2 mA) or sham stimulation over bilateral DLPFC. WCST and IGT were readministered following the last session. Baseline clinical severity, depression, impulsivity levels, and cognitive performance were similar between groups. TDCS over the DLPFC resulted in more advantageous decision making (F-1,F-16 = 8.128, p = 0.01, eta p(2) = 0.33) and better cognitive flexibility (F-1,F-16 = 8.782, p = 0.009, eta p(2) = 0.35), representing large effect sizes. The results suggest for the first time that tDCS enhanced decision making and cognitive flexibility in gambling disorder. Therefore, tDCS may be a promising neuromodulation-based therapeutic approach in gambling disorder.en_US
dc.identifier.citationSoyata, A. Z., Aksu, S., Woods, A. J., İşçen, P., Saçar, K. T., & Karamürsel, S. (2019). Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder. European archives of psychiatry and clinical neuroscience, 269(3), 275-284.en_US
dc.identifier.doi10.1007/s00406-018-0948-5en_US
dc.identifier.endpage284en_US
dc.identifier.issn0940-1334en_US
dc.identifier.issn1433-8491en_US
dc.identifier.issue3en_US
dc.identifier.pmid30367243en_US
dc.identifier.scopus2-s2.0-85055867953en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1007/s00406-018-0948-5
dc.identifier.urihttps://hdl.handle.net/20.500.12713/641
dc.identifier.volume269en_US
dc.identifier.wosWOS:000464862700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaramürsel, Saciten_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAddictive Disordersen_US
dc.subjectGambling Disorderen_US
dc.subjectTranscranial Direct Current Stimulationen_US
dc.subjectDecision Makingen_US
dc.subjectExecutive Functionsen_US
dc.subjectCognitive Functionsen_US
dc.titleEffect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorderen_US
dc.typeArticleen_US

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