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Öğe How reliable is the high-volume definition in prostate cancer patients: the potential game-changing role of PSMA(Lippincott Williams & Wilkins, 2023) Guven, Osman; Karyagar, Savas; Arici, Serdar; Ozulker, Tamer; Can, OrcunPurposeTo evaluate whether metabolic and volumetric data from Ga-68-PSMA PET/CT performed during staging of de-novo high-volume mCSPC patients who received docetaxel could be used to predict survival. MethodsForty-two de-novo high-volume mCSPC patients, who received ADT + Docetaxel and underwent Ga-68-PSMA PET/CT for staging, were included in the study. The association between patients' pathological data, all PSA measurements, treatments they received, the data obtained from Ga-68-PSMA PET/CT and progression-free and overall survival were examined. ResultsIn the multivariate analysis, PSMA-TV (primary) and PSMA-TV (WB) variables were shown to be independent negative predictors of overall survival. For the threshold value of 19.91 cm(3) obtained for PSMA-TV (primary), HR was calculated as 6.31, the 95% confidence interval (CI): 1.01-39.18, P = 0.048. For the threshold value of 1226.5 cm(3) obtained for PSMA-TV (WB) variable, HR was calculated as 58.62, the 95% CI: 2.55-1344.43, P = 0.011. In our study, SUVmax (WB) variable was found to be an independent and negative predictor of progression-free survival. For the determined threshold value of 17.74, HR was calculated as 16.24, 95% CI: 1.18-22.76, P = 0.037. ConclusionMetabolic and volumetric data obtained from Ga-68-PSMA PET/CT can be used to predict survival in de-novo high-volume mCSPC. Our results show that in ADT + Docetaxel receiving patients, a subgroup with higher PSMA-TV (WB) values have a significantly worse prognosis. This situation suggests that the high-volume disease definition in the literature may be insufficient for this group, and that Ga-68-PSMA PET/CT can play an essential role in demonstrating the heterogeneity within the group.Öğe Effect of embelin on inhibition of cell growth and induction of apoptosis in Acanthamoeba castellanii(Springer, 2023) Ahmed, Usman; Ong, Seng-Kai; Khan, Khalid Mohammed; Siddiqui, Ruqaiyyah; Khan, Naveed Ahmed; Shaikh, Mohd Farooq; Alawfi, Bader SaleemAcanthamoeba castellanii is the causative agent of fatal encephalitis and blinding keratitis. Current therapies remain a challenge, hence there is a need to search for new therapeutics. Here, we tested embelin (EMB) and silver nanoparticles doped with embelin (EMB-AgNPs) against A. castellanii. Using amoebicidal assays, the results revealed that both compounds inhibited the viability of Acanthamoeba, having an IC50 of 27.16 +/- 0.63 and 13.63 +/- 1.08 mu M, respectively, while causing minimal cytotoxicity against HaCaT cells in vitro. The findings suggest that both samples induced apoptosis through the mitochondria-mediated pathway. Differentially expressed genes analysis showed that 652 genes were uniquely expressed in treated versus untreated cells, out of which 191 were significantly regulated in the negative control vs. conjugate. Combining the analysis, seven genes (ARIH1, RAP1, H3, SDR16C5, GST, SRX1, and PFN) were highlighted as the most significant (Log2 (FC) value +/- 4) for the molecular mode of action in vitro. The KEGG analysis linked most of the genes to apoptosis, the oxidative stress signaling pathway, cytochrome P450, Rap1, and the oxytocin signaling pathways. In summary, this study provides a thorough framework for developing therapeutic agents against microbial infections using EMB and EMB-AgNPs.Öğe Verifying the seating of a 3D-printed removable die using elastomeric matrices: A dental technique(Wiley, 2024) Azpiazu-Flores, Francisco X.; Donmez, Mustafa Borga; Lin, Wei-Shao; Morton, Dean; Yilmaz, BurakComputer-aided design and computer-aided manufacturing systems enable digital designing and 3-dimensional (3D) printing of definitive casts with removable dies. However, the fit of the removable dies should be without interferences for their accurate positioning in the cast. Given that the accuracy of additive manufacturing depends on design- and manufacturing-related factors, verifying the accuracy of the position of 3D-printed removable dies in their cast is essential to fabricate positionally accurate definitive prostheses, which would enable minimal or no laboratory and clinical adjustments. This dental technique article presents a straightforward approach to verify the seating of a 3D-printed removable die by using verification matrices made of a polyvinylsiloxane interocclusal registration material.Öğe Novel 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide based thiosemicarbazides as potent and selective inhibitors of tumor-associated human carbonic anhydrase IX and XII: Synthesis, cytotoxicity, and molecular modelling studies(Academic Press Inc Elsevier Science, 2024) Demir-Yazici, Kubra; Trawally, Muhammed; Bua, Silvia; Ozturk-Civelek, Dilek; Akdemir, Atilla; Supuran, Claudiu T.; Guzel-Akdemir, OzlenIn the pursuit of discovering new selective carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, a small collection of novel thiosemicarbazides (5a-5t) were designed and synthesized starting from 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide which was evaluated as a potent inhibitor of different CA isoforms in a previous study. The newly synthesized compounds were examined against four human carbonic anhydrases (hCA), namely transmembrane tumor-related hCA IX/XII and cytosolic widespread off-targets hCA I/II. In enzyme inhibition assays, all nineteen compounds display up to similar to 340-fold selectivity for hCA IX/XII over off-target isoforms hCA I/II. Four compounds have enzyme inhibition values (K-i) lower than 10 nM against tumor-associated isoforms hCA IX/XII including two compounds in the subnanomolar range (5r and 5s; hCA XII; K-i: 0.69 and 0.87 nM). The potential binding interactions of the most potent compounds against hCA IX and XII, compounds 5s and 5r, respectively, were investigated using ensemble docking and molecular dynamics studies. Cell viability assays using human colorectal adenocarcinoma cell line HT-29 and healthy skin fibroblasts CCD-86Sk show that compound 5e selectively inhibits HT-29 cancer cell proliferation (IC50: 53.32 +/- 7.74 mu M for HT-29; IC50: 74.64 +/- 14.15 mu M for CCD-986Sk). Finally, Western blot assays show that compounds 5e and 5r significantly reduce the expression of hCA XII in HT-29 cells. Moreover, 5e shows better cytotoxic activity in hypoxia compared to normoxic conditions. Altogether, the newly designed compounds show stronger inhibition of the tumor-associated hCA IX and XII isoforms and several tested compounds show selective cytotoxicity as well as downregulation of hCA XII expression.Öğe Effect of computer-aided design and computer-aided manufacturing technique on the accuracy of fixed partial denture patterns used for casting or pressing(Elsevier Sci Ltd, 2023) Donmez, Mustafa Borga; Yilmaz, Burak; Yoon, Hyung-In; Kahveci, Cigdem; Schimmel, Martin; Cakmak, GulceObjectives: To evaluate the effect of additive and subtractive manufacturing on the accuracy (trueness and pre-cision) of fixed partial denture patterns (FPDPs) used for casting or pressing.Materials and Methods: A 3-unit complete coverage FPD on mandibular right first premolar and first molar teeth was virtually designed. Using the design data, FPD patterns were fabricated from an additively manufactured resin (PR, ProArt Print Wax) and 2 CAD-CAM wax discs (YW, ProArt CAD Wax Yellow and BW, ProArt CAD Wax Blue) (n = 10). Each pattern was then digitized with a scanner (CEREC Primescan) and evaluated for 3D surface deviation at 4 different surfaces (overall, external, marginal, and intaglio surfaces) by using a 3D analysis software (Medit Link). Root mean square (RMS) values were automatically calculated. Data were analyzed by using Kruskal-Wallis and Dunn's post hoc tests for trueness and precision (alpha= 0.05).Results: Significant differences were found among the RMS values for overall (P<.001) and each surface (P <=.040) evaluated. PR had the highest overall (P <=.011) and intaglio surface (P <=.01) deviations, while the difference between YW and BW was not significant (P >=.199). PR had the highest (P <=.027) and BW had the lowest (P <=.042) external surface mean RMS values. BW had higher mean marginal RMS value than YW (P=.047). For precision, significant differences were observed among test groups only for marginal RMS values (P=.002). PR had lower precision than BW (P=.002).Conclusions: BW and YW FPDPs mostly had higher trueness compared with PR FPDPs. However, considering relatively smaller deviations at marginal and intaglio surfaces and the fact that patterns mostly had similar precision, clinical fit of FPDs fabricated by using tested patterns may be similar.Clinical Significance: Definitive 3-unit fixed partial dentures fabricated by using tested patterns may be similar. However, FPDs fabricated with tested additively manufactured resin patterns might result in more chairside adjustments than those fabricated with tested subtractively manufactured wax patterns.Öğe Surface characteristics and wettability of novel gingival col designed 3-D printed dental sectional matrices(Walter De Gruyter Gmbh, 2024) Celik, Zeynep Ceren; Elbek Cubukcu, Cigdem; Celik, HalilObjective: The physical properties and wettability of 3-D printed Polyethylene terephthalate - glycol (PET-G) and Poly(lactic) acid (PLA) dental sectional matrices were investigated. Methods: Experimental matrices was designed in a rectangular shape one-side depression corresponds to gingival col and without sharp edges and printed on FDM machine Ender Pro 3 (Creality((R)), Shenzhen, China). The physical textures, thicknesses, water contact angles were compared to conventional stainless steel (SS) matrix. Results: PETG and PLA sample matrices were clinically single-side smooth compared to SS matrix. PETG specimens had uniformly 0.055 mm whereas PLAs were non-uniformly similar to 0.065-0.075 mm in thickness. The mean +/- standard deviation (SS) of contact angle for SS was 78.29 +/- 0.18, for PETG was 72.09 +/- 0.94, for PLA was 73.03 +/- 1.17. Conclusion: PETG and PLA dental matrices might have desirable properties: being hydrophobic, non-charged, easy to manufacture and mimicking the gingival col depression in the dental interproximal contact area.Öğe Dermatoscopic Features of Early Erythema Chronicum Migrans(Croation Dermatovenerological Soc, 2023) Ozcan, Yunus; Takir, Sumeyye Gunes; Karagun, Ebru; Uyar, Belkiz[Abstract Not Available]Öğe Germinoma Misdiagnosed as Lymphocytic Hypophysitis(Galenos Publ House, 2023) Sahin, Serdar; Baskurt, Ozan; Comunoglu, Nil; Kadioglu, Pinar; Gazioglu, Nurperi[Abstract Not Available]Öğe Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications(Galenos Publ House, 2023) Yalta, Kenan; Yetkin, Ertan; Yalta, TuelinIn cardiooncology practice, early cardiotoxicity refers to an emerging subclinical myocardial dysfunction/injury in response to certain chemotherapeutic regimens. This condition can progress to overt cardiotoxicity in time and hence warrants proper and timely diagnostic and preventive strategies. Current diagnostic strategies for early cardiotoxicity are largely based on conventional biomarkers and certain echocardiographic indices. However, a significant gap still exists in this setting, warranting further strategies to improve diagnosis and overall prognosis in cancer survivors. Copeptin (surrogate marker of the arginine vasopressine axis) might serve as a promising adjunctive guide for the timely detection, risk stratification, and management of early cardiotoxicity on top of conventional strategies largely due to its multifaceted pathophysiological implications in the clinical setting. This work aims to focus on serum copeptin as a marker of early cardiotoxicity and its general clinical implications in patients with cancer.Öğe Microbiome and One Health: Potential of Novel Metabolites from the Gut Microbiome of Unique Species for Human Health(Mdpi, 2023) Siddiqui, Ruqaiyyah; Khan, Naveed Ahmed[Abstract Not Available]Öğe Materials for Infectious Diseases(Mdpi, 2023) Zarrabi, Ali; Caldera, Fabrizio; Trotta, Francesco[Abstract Not Available]Öğe Could the Convergence of Science and Technology Guarantee Human Health in the Future?(Mdpi, 2023) Zarrabi, Ali[Abstract Not Available]Öğe Occluding Efficiency of Different Desensitizing Agents and Er,Cr:YSGG Laser on Dentin Tubules(Operative Dentistry Inc, 2024) Uslu, Y. S.; Donmez, N.; Gungor, A. S.; Akalin, T. T.; Ulukapi, H.Purpose: This study aimed to evaluate the effects of two desensitizers and the Er,Cr:YSGG laser on human dentin tubules, applied alone or in combination. Methods: Ninety-six dentin specimens were obtained from extracted third molars and divided into six groups: Group 1: no -treatment (Control); Group 2: nano-hydroxyapatite desensitizer (NhapD); Group 3: NhapD+Er,Cr:YSGG laser (L); Group 4: Er,Cr:YSGG laser (L); Group 5: glutaraldehyde desensitizer (GD); and Group 6: GD+L, respectively. All specimens were evaluated using scanning electron microscopy. The diameter and the number of open dentin tubules, the tubules' occluding ratio, and the mineral coverage area were measured via the Image J software at 2000x magnification. Atomic force microscopy was used to determine the blocking mechanism of desensitizing treatments and the surface morphology of dentin specimens. One-way ANOVA and Tukey tests were used for statistical analysis. Results: The number of open tubules and the mean diameter of tubules for all treatment groups showed statistically significant differences from the control group The NhapD+L group had a significantly lower number of open tubules than the L and GD groups. The NhapD+L and L groups significantly had higher occluding ratios than the other groups. Conclusions: The present study showed that the Er,Cr:YSGG laser alone was effective in terms of tubule occlusion and also contributed to increasing the occluding ratio of nano-hydroxyapatite. It may be recommended to use the Er,Cr:YSGG laser with nano-hydroxyapatite desensitizers to achieve effective tubule occlusionÖğe Bacterial flora varies throughout the saltwater crocodile (Crocodylus porosus) gastrointestinal tract(Amer Veterinary Medical Assoc, 2023) Siddiqui, Ruqaiyyah; Maciver, Sutherland K.; Anuar, Tengku Shahrul; Khan, Naveed AhmedOBJECTIVEThe objective of this study was to determine bacterial flora throughout the gastrointestinal tract of a saltwater crocodile (Crocodylus porosus) using 16S rRNA gene analysis.ANIMALSA convention on international trade in endangered species (CITES) of wild fauna and flora registered crocodile farm, provided a healthy male saltwater crocodile, Crocodylus porosus for this study.PROCEDURESThree samples were taken from the oral cavity, 3 samples from the proximal region of the small intestine (jejunum), and 3 samples from the distal part of the large intestine of the gastrointestinal tract of C. porosus were obtained using sterile cotton swabs. Next, swabs were placed in 15 mL sterile centrifuge tubes, individually, and kept on ice for immediate transportation to the laboratory. This was followed by 16S rRNA gene analysis using specific prim- ers (341F-CCTAYGGGRBGCASCAG, and 806R-GGACTACNNGGGTATCTAAT). Amplicons were sequenced on Illumina paired-end platform, and bacterial gastrointestinal communities, the relative abundance of taxa, and principal component and coordinate analysis were performed.RESULTSThe findings revealed that bacterial community structures from differing regions exhibited several differences. The number of observed bacterial operational taxonomic units (OTUs) was 153 in the oral cavity, 239 in the small intestine, and 119 in the large intestine of C. porosus. The small intestine reflects the highest richness. In contrast, the large intes- tine exhibited the least richness of microbial communities. Relative abundance of taxa showed that Proteobacteria, Bacteroidetes, and Firmicutes were dominant in all 3 sample sites. Pseudomonas differed in the oral cavity and the large intestine, with the latter exhibiting less distribution of Pseudomonas. Stenotrophomonas and Castellaniella were higher in the oral cavity, while the relative abundance of Comamonas and Salmonella was higher in the small intestine. Conversely, the relative abundance of Salmonella and Pannonibacter was augmented in the large intestine.CLINICAL RELEVANCEFor the first time, this study demonstrates the bacterial diversity along the segments of the gastrointestinal tract of C. porosus. Bacterial flora varies throughout the gastrointestinal tract. Although further studies using large cohorts are warranted; however, our findings suggest that microbiome composition may have the potential as a biomarker in determining the overall health and well-being of C. porosus.Öğe Importance of human papillomavirus genotyping and standardized sampling in men(Assoc Medica Brasileira, 2023) Sarier, Mehmet[Abstract Not Available]Öğe Assessing geochemical and natural radioactivity impacts of Hamadat phosphatic mine through radiological indices(Public Library Science, 2023) Fathy, Douaa; Zakaly, Hesham M. H. S.; Lasheen, El Saeed R.; Elsaman, Reda A.; Alarifi, Saad; Sami, Mabrouk; Awad, HamdyThe utilization of phosphorite deposits as an industrial resource is of paramount importance, and its sustainability largely depends on ensuring safe and responsible practices. This study aims to evaluate the suitability of phosphorite deposits for industrial applications such as the production of phosphoric acid and phosphatic fertilizers. To achieve this goal, the study meticulously examines the geochemical characteristics of the deposits, investigates the distribution of natural Radioactivity within them, and assesses the potential radiological risk associated with their use. The phosphorites are massive and collected from different beds within the Duwi Formation at the Hamadat mining area. They are grain-supported and composed of phosphatic pellets, bioclasts (bones), non-phosphatic minerals, and cement. Geochemically, phosphorites contain high concentrations of P2O5 (23.59-28.36 wt.%) and CaO (40.85-44.35 wt.%), with low amounts of Al2O3 (0.23-0.51 wt.%), TiO2 (0.01-0.03 wt.%), Fe2O3 (1.14-2.28 wt.%), Na2O (0.37-1.19 wt.%), K2O (0.03-0.12 wt.%), and MnO (0.08-0.18 wt.%), suggesting the low contribution of the detrital material during their deposition. Moreover, they belong to contain enhanced U concentration (55-128 ppm). They are also enriched with Sr, Ba, Cr, V, and Zn and depleted in Th, Zr, and Rb, which strongly supports the low detrital input during the formation of the Hamadat phosphorites. The high Radioactivity of the studied phosphorites is probably due to the widespread occurrence of phosphatic components (e.g., apatite) that accommodate U in high concentrations. Gamma spectrometry based on NaI (Tl) crystal 3x3 has been used to measure occurring radionuclides in the phosphorite samples. The results indicate that the radioactive concentrations' average values of Ra-226, Th-232, and K-40 are 184.18 & PLUSMN;9.19, 125.82 & PLUSMN;6.29, and 63.82 & PLUSMN;3.19 Bq Kg(,)(-1) respectively. Additionally, evaluations have been made of the radiological hazards. The calculated risk indicators exceeded the recommended national and world averages. The data obtained will serve as a reference for follow-up studies to evaluate the effectiveness of the Radioactivity of phosphatic materials collected from the Hamdat mine area.Öğe Cell formation and layout design using genetic algorithm and TOPSIS: A case study of Hydraulic Industries State Company(Public Library Science, 2024) Dhayef, Dhulfiqar Hakeem; Al-Zubaidi, Sawsan S. A.; Al-Kindi, Luma A. H.; Tirkolaee, Erfan BabaeeCell formation (CF) and machine cell layout are two critical issues in the design of a cellular manufacturing system (CMS). The complexity of the problem has an exponential impact on the time required to compute a solution, making it an NP-hard (complex and non-deterministic polynomial-time hard) problem. Therefore, it has been widely solved using effective meta-heuristics. The paper introduces a novel meta-heuristic strategy that utilizes the Genetic Algorithm (GA) and the Technique of Order Preference Similarity to the Ideal Solution (TOPSIS) to identify the most favorable solution for both flexible CF and machine layout within each cell. GA is employed to identify machine cells and part families based on Grouping Efficiency (GE) as a fitness function. In contrast to previous research, which considered grouping efficiency with a weight factor (q = 0.5), this study utilizes various weight factor values (0.1, 0.3, 0.7, 0.5, and 0.9). The proposed solution suggests using the TOPSIS technique to determine the most suitable value for the weighting factor. This factor is critical in enabling CMS to design the necessary flexibility to control the cell size. The proposed approach aims to arrange machines to enhance GE, System Utilization (SU), and System Flexibility (SF) while minimizing the cost of material handling between machines as well as inter- and intracellular movements (TC). The results of the proposed approach presented here show either better or comparable performance to the benchmark instances collected from existing literature.Öğe Comparison of the results of stop-start technique with stop-start technique and sphincter control training applied in premature ejaculation treatment(Public Library Science, 2023) Dogan, Kazim; Kece, CemBackgroundThe aim of this study is to compare the results of stop-start technique with stop-start technique together with sphincter control training applied in the treatment of premature ejaculation. MethodsThis research was conducted as a pre-test post-test quasi-experimental study. The sample of the study consisted of 80 men. The study was conducted on men who applied to the urology outpatient clinic of LIV Hospital, a private hospital, in Gaziantep, Turkey, between 01 October 2021 and 01 March 2022. Personal Information Form, Intravaginal Ejaculation Latency Time (IELT), Fold Increase Intravaginal Ejaculation Latency Time (F-IELT) Premature Ejaculation Diagnostic Tool (PEDT) Questionnaire and Arabic Index Premature Ejaculation (AIPE) were used as the data collection tools. Behavioral therapy, consisting of a total of 6 sessions, was applied once every two weeks, with each session lasting for 45 minutes. After 3rd and 6th months from the beginning of the application, the data collection tools were applied again. Stop-Start Technique (Group A) and Stop-Start Technique and Sphincter Control Training (Group B) were used in the treatment. ResultsIn both groups, the IELT and AIPE values after 3rd and 6th months from the beginning of the application were statistically higher than those obtained before (p<0.05). IELT and AIPE values increased more in Group B than Group A (p<0.05). F-IELT values after 6th months from the beginning of the application were found to be statistically significant with a low level of effect size than those obtained before (p<0.05, Cohen's d = 0.027). In both groups, the PEDT values in the 3rd and 6th months after the application were statistically lower than those seen before (p<0.05). PEDT value decreased more in Group B than Group A (p<0.05). The differences between the two groups' IELT (Cohen's d = 0.011), AIPE (Cohen's d = 0.044), and PEDT (Cohen's d = 0.066) values in the 3rd month after the application and IELT (Cohen's d = 0.025), AIPE (Cohen's d = 0.048), and PEDT (Cohen's d = 0.024) values in the 6th month after the application were found to be clinically weak. ConclusionsIt was determined that the stop-start technique given to men with premature ejaculation increased the time spent in the vagina and eliminated the problem of premature ejaculation. It was determined that the stop-start technique in combination with sphincter control training were more effective than the stop-start technique alone.Öğe In Reply: Opening the Parieto-Occipital Fissure for Periatrial Metastasis: 2-Dimensional Operative Video(Lippincott Williams & Wilkins, 2024) Dogruel, Yucel; Rahmanov, Serdar; Gungor, Abuzer; Ture, Ugur[Abstract Not Available]Öğe Does papillary muscle free strain has predictive value in risk stratification of patients with hypertrophic cardiomyopathy?(Public Library Science, 2023) Koyuncu, Atilla; Yildiz, Cennet; Ocal, Lutfu; Kalkan, Sedat; Kilicgedik, Alev; Guersoy, Mustafa Ozan; Oflar, ErsanBackgroundPapillary muscle free strain has not been evaluated previously in hypertrophic cardiomyopathy (HCMP) patients. Our aim was to evaluate free papillary muscle free strain in HCMP patients and to find whether it has a value for prediction of sudden cardiac death (SCD) risk score. MethodsTransthoracic echocardiography with tissue Doppler imaging, 2-D speckle tracking imaging (STI) of 55 HCMP patients and 45 controls were performed. HCMP patients were further divided into two groups according to their SCD risk score. Patients with risk score of less than 6 points constituted low/intermediate risk group, whereas patients with risk score of greater or equal to 6 points constituted high risk group. ResultsInterventricular septum, posterior wall, and left ventricular mass index were significantly higher, whereas mitral E/A ratio was significantly lower in HCMP patients compared to controls. Longitudinal apical 4C, 2C, 3C, global longitudinal LV strain, anterolateral papillary muscle (ALPM), posteromedial papillary muscle (PMPM) free strain were significantly reduced in HCMP group compared to control group. Global longitudinal strain and ALPM free strain were significantly lower in patients with high SCD risk score (-14.6 (-17.4 - -13.1) vs -11.6 (-13.2 - -10.1), p = 0.001 and -17.1 (-20.3 - -14.0) vs -9.2 (-12.6 - -7.5), p<0.001, respectively. Global longitudinal strain and ALPM free strain were statistically significantly correlated with SCD risk score (r = 0.480, p<0.001 and r = 0.462, p<0.001, respectively). Global longitudinal strain value of -12.60% had a sensitivity of 73.3% and specificity of 82.5% for predicting high SCD risk score (AUC: 0.787, 95% CI: 00.643-0.930, p = 0.001). ALPM free strain value of -12.95% had 66.7% sensitivity and 77.5% specificity for predicting high SCD risk score (AUC: 0.766, 95% CI: 0.626-0.905, p = 0.003). ConclusionPapillary muscle free strain was reduced in HCMP patients. It might be used in risk stratification of these patients.
