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    Effects of novel targeted anticancer drugs on cytotoxicity, apoptosis, angiogenesis, EMT, drug resistance and autophagic mechanism
    (Oxford Univ Press, 2019) Aydınlık, S.; Üvez, A.; Armutak, E. I.; Dere, E.; Ulukaya, Engin
    Background: Metastatic coloncancer has asurvival rate less than %5 despite the use of effective chemotherapeutic regimen. Prognosticand predictiveimportance of EGFR is still contradictivein coloncancer. Tyrosine kinase inhibitor canertinib was used in this study toblock the EGFR receptor. Theeffectof Palladium (Pd) (II)compound [PdCl(terpy)](sac).2H2O]andcanertinib combination treatment was investigated in this study. 5-fluorouracil(5-FU),a chemotherapeutic drug was used aspositive control.