Yazar "Avci, Idris" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Evaluation of neurogranin levels in a rat model of diffuse axonal injury
    (Nencki Inst Experimental Biology, 2024) Baskurt, Ozan; Aydin, Seckin; Avci, Idris; Nayir, Pinar Ozay; Aydin, Mehmet Volkan
    Diffuse axonal injury (DAI), one of the most common and devastating type of traumatic brain injury, is the result of the shear force on axons due to severe rotational acceleration and deceleration. Neurogranin (NRGN) is a postsynaptic protein secreted by excitatory neurons, and synaptic dysfunction can alter extracellular NRGN levels. In this study, we examined NRGN levels in serum and cerebrospinal fluid (CSF) after experimental DAI in terms of their diagnostic value. Experimental DAI was induced using the Marmarou technique in male Wistar albino rats. Serum and CSF NRGN levels of the sham group, one-hour, six-hour, 24-hour, and 72-hour post-DAI groups were measured by ELISA method. DAI was verified by staining with hematoxylin-eosin and beta-amyloid precursor protein in the rat brain samples. While no histopathological and immunohistochemical changes were observed in the early hours of the post-DAI groups, the staining of the beta-APP visibly increased over time, with positivity being most frequent and intense in the 72-hour group. It was found that serum NRGN levels were significantly lower in the 6-hour group than in the sham group. The serum NRGN levels in the 24-hour group were significantly higher than those in the sham group. This study showed a dichotomy of post-DAI serum NRGN levels in consecutive time periods. NRGN levels in CSF were higher in the one-hour group than in the sham group and returned to baseline by 72 hours, although not significantly. Our study provides an impression of serum and CSF NRGN levels in a rat DAI model in consecutive time periods. Further studies are needed to understand the diagnostic value of NRGN.
  • Küçük Resim Yok
    Öğe
    Prognostic significance of prolonged corrected QT interval in cerebral contusion
    (Wolters Kluwer Medknow Publications, 2023) Yavuz, Ahmed Yasin; Baskurt, Ozan; Kurtulus, Yunus; Avci, Idris
    Background & objectives: Cerebral contusion (CC) results in a release of catecholamines, autonomic dysfunction and neural stimulation that can lead to a number of cardiac adverse events, so it is critical to determine these. So the objective of this study was to investigate the prognostic significance of electrocardiographic changes, particularly the effects of a prolonged corrected QT (QTc) interval in CC. Methods: In this retrospective cohort study, 110 patients with CC were evaluated. Age, sex, concomitant diseases, Glasgow Coma Scale on admission, radiological assessment of the contusion (location, size, course and presence of cerebral oedema), need for surgical intervention, length of hospital stay and the extended Glasgow Outcome Scale (GOS-E) were statistically analysed within the QTc interval by routine electrocardiography (ECG) on admission. Results: The prolonged QTc interval was found to be associated with a higher incidence of cerebral oedema and a significantly higher risk of needing surgery. Patients with a prolonged QTc interval had a significantly larger contusion volume, greater midline shift and longer hospital stay, so their GOS-E score was significantly lower. A prolonged QTc interval on admission resulted in a hospital stay of more than eight days (sensitivity: 0.97 and specificity: 0.86), a higher risk of midline shift of more than 0.45 cm (P=0.006, sensitivity: 0.80 and specificity: 0.99) and a GOS-E score of <7 (sensitivity: 0.97 and specificity: 0.85). Interpretation & conclusions: ECG changes on admission showing a prolonged QTc interval have prognostic significance in CC. This simple and easily applicable information should be taken into consideration at the time of clinical decision making which may prevent an adverse events survivor.