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The relationship between the level of ?-opioid receptor (?ORs) and postoperative analgesic use in patients undergoing septoplasty: a prospective randomized controlled trial
(NLM (Medline), 2020) Gencer, Muzaffer; Gocmen, Ayse Yesim
BACKGROUND: In this study, the ?-Opioid receptor activity was assessed pre-operatively for its association with postoperative pain level and second analgesic requirement in patients undergoing septoplasty. METHODS: In our prospective study, 120 adult patients underwent septoplasty from June 2015 to January 2019 were randomly divided into 2 pre-operative groups. The first group (n?=?60) was patients given tramadol (1-2?mg/kg) for post-operative analgesia, and the second group (control group) (n?=?60) was initially prescribed only fentanyl (1??g/ kg-i.v.) in the induction. Acetaminophen with codeine analgesic 325/30?mg (p.o.) was used as an rescue painkiller in the post-operative period. The ?-Opioid receptor activity was investigated in pre-operative blood samples and compared to post-operative pain level and time required for second round of analgesic administration. The visual analogue score (VAS) was used to evaluate the post-operative pain degree (0 no pain; 10 worst pain). The patients' post-operative VAS scores were evaluated upon arrival to recovery room, and at the 1st, 3rd, 7th, 10th, and 24th hour post-operative period. RESULTS: Demographic data and peri-operative variables were similar in both study group (p?