The relationship between the level of ?-opioid receptor (?ORs) and postoperative analgesic use in patients undergoing septoplasty: a prospective randomized controlled trial
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NLM (Medline)
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BACKGROUND: In this study, the ?-Opioid receptor activity was assessed pre-operatively for its association with postoperative pain level and second analgesic requirement in patients undergoing septoplasty. METHODS: In our prospective study, 120 adult patients underwent septoplasty from June 2015 to January 2019 were randomly divided into 2 pre-operative groups. The first group (n?=?60) was patients given tramadol (1-2?mg/kg) for post-operative analgesia, and the second group (control group) (n?=?60) was initially prescribed only fentanyl (1??g/ kg-i.v.) in the induction. Acetaminophen with codeine analgesic 325/30?mg (p.o.) was used as an rescue painkiller in the post-operative period. The ?-Opioid receptor activity was investigated in pre-operative blood samples and compared to post-operative pain level and time required for second round of analgesic administration. The visual analogue score (VAS) was used to evaluate the post-operative pain degree (0 no pain; 10 worst pain). The patients' post-operative VAS scores were evaluated upon arrival to recovery room, and at the 1st, 3rd, 7th, 10th, and 24th hour post-operative period. RESULTS: Demographic data and peri-operative variables were similar in both study group (p?<?0.05).There was no significant difference between the receptor levels in both groups and the mean receptor level was 200.94?±?15.34?pg/mL (max:489.92?±?22.36?pg/mL, min: 94.56?±?11.23?pg/mL).In patients who used tramadol as the levels of ?-Opioid receptors increased, VAS scores of patients and second analgesic use decreased in post-operative period.The VAS scores in patients with higher receptor levels were lower in the recovery room (p?<?0.05), 1st (p?<?0.05) and 3rd hours (p?<?0.05).The VAS scores were lower in the tramadol group compared to the control group (p?<?0.05).Number of secondary analgesic requirement was significantly lower in patients of the tramadol group with higher receptor levels compared to the ones with lower receptor (p <?0.05) for arrival at the recovery room and 1st hour. Patients in the tramadol group needed a second pain killer much later than patients in the control group. CONCLUSIONS: Our study demonstrates that patients with higher ?OR levels have a higher efficacy of opioid analgesic agents and an lesser need for additional analgesic agents. TRIAL REGISTRATION: This trial was registered retrospectively (The ACTRN: ACTRN12619001652167 , registration date: 26/11/2019).
Açıklama
Anahtar Kelimeler
Analgesic Agent, Septoplasty, Tramadol, μ-Opioid receptor (μORs)
Kaynak
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
20
Sayı
1
Künye
Gencer, M., & Göçmen, A. Y. (2020). The relationship between the level of μ-opioid receptor (μORs) and postoperative analgesic use in patients undergoing septoplasty: a prospective randomized controlled trial. BMC anesthesiology, 20(1), 1-8.
