The relationship between the level of ?-opioid receptor (?ORs) and postoperative analgesic use in patients undergoing septoplasty: a prospective randomized controlled trial

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dc.authoridMuzaffer Gencer / 0000-0002-3324-5106
dc.authorscopusidMuzaffer Gencer / 57218915766
dc.authorwosidMuzaffer Gencer / EWA-8922-2022
dc.contributor.authorGencer, Muzaffer
dc.contributor.authorGocmen, Ayse Yesim
dc.date.accessioned2020-09-21T12:28:47Z
dc.date.available2020-09-21T12:28:47Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Bölümüen_US
dc.description.abstractBACKGROUND: In this study, the ?-Opioid receptor activity was assessed pre-operatively for its association with postoperative pain level and second analgesic requirement in patients undergoing septoplasty. METHODS: In our prospective study, 120 adult patients underwent septoplasty from June 2015 to January 2019 were randomly divided into 2 pre-operative groups. The first group (n?=?60) was patients given tramadol (1-2?mg/kg) for post-operative analgesia, and the second group (control group) (n?=?60) was initially prescribed only fentanyl (1??g/ kg-i.v.) in the induction. Acetaminophen with codeine analgesic 325/30?mg (p.o.) was used as an rescue painkiller in the post-operative period. The ?-Opioid receptor activity was investigated in pre-operative blood samples and compared to post-operative pain level and time required for second round of analgesic administration. The visual analogue score (VAS) was used to evaluate the post-operative pain degree (0 no pain; 10 worst pain). The patients' post-operative VAS scores were evaluated upon arrival to recovery room, and at the 1st, 3rd, 7th, 10th, and 24th hour post-operative period. RESULTS: Demographic data and peri-operative variables were similar in both study group (p?<?0.05).There was no significant difference between the receptor levels in both groups and the mean receptor level was 200.94?±?15.34?pg/mL (max:489.92?±?22.36?pg/mL, min: 94.56?±?11.23?pg/mL).In patients who used tramadol as the levels of ?-Opioid receptors increased, VAS scores of patients and second analgesic use decreased in post-operative period.The VAS scores in patients with higher receptor levels were lower in the recovery room (p?<?0.05), 1st (p?<?0.05) and 3rd hours (p?<?0.05).The VAS scores were lower in the tramadol group compared to the control group (p?<?0.05).Number of secondary analgesic requirement was significantly lower in patients of the tramadol group with higher receptor levels compared to the ones with lower receptor (p <?0.05) for arrival at the recovery room and 1st hour. Patients in the tramadol group needed a second pain killer much later than patients in the control group. CONCLUSIONS: Our study demonstrates that patients with higher ?OR levels have a higher efficacy of opioid analgesic agents and an lesser need for additional analgesic agents. TRIAL REGISTRATION: This trial was registered retrospectively (The ACTRN: ACTRN12619001652167 , registration date: 26/11/2019).en_US
dc.identifier.citationGencer, M., & Göçmen, A. Y. (2020). The relationship between the level of μ-opioid receptor (μORs) and postoperative analgesic use in patients undergoing septoplasty: a prospective randomized controlled trial. BMC anesthesiology, 20(1), 1-8.en_US
dc.identifier.doi10.1186/s12871-020-01138-zen_US
dc.identifier.issn1471-2253en_US
dc.identifier.issue1en_US
dc.identifier.pmid32900361en_US
dc.identifier.scopus2-s2.0-85090726462en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://doi.org/10.1186/s12871-020-01138-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1051
dc.identifier.volume20en_US
dc.identifier.wosWOS:000571000300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGencer, Muzaffer
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnalgesic Agenten_US
dc.subjectSeptoplastyen_US
dc.subjectTramadolen_US
dc.subjectμ-Opioid receptor (μORs)en_US
dc.titleThe relationship between the level of ?-opioid receptor (?ORs) and postoperative analgesic use in patients undergoing septoplasty: a prospective randomized controlled trialen_US
dc.typeArticleen_US

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