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Öğe EXPERIENCES OF PARENTS WHO CONCEIVED SAVIOR SIBLINGS FOR BEING HEMATOPOIETIC STEM CELL DONORS TO THEIR SICK CHILDREN AND SUCCESSFULLY COMPLETED THE PROCESS: A QUALITATIVE STUDY(Springernature, 2023) Eker, Ibrahim; Ozdemir, Hamide Nur Cevik; Yilmaz, Firat; Yesilipek, Akif; Kupesiz, Alphan; Uygun, Vedat; Karasu, Gulsun[Abstract Not Available]Öğe Impact of Replacing Low Dose Cyclophosphamide with Fludarabine in Children with Acute Myeloid Leukemia Undergoing Transplantation During First Complete Remission(Akad Doktorlar Yayinevi, 2023) Uygun, Vedat; Karasu, Gulsun; Yalcin, Koray; Ozturkmen, Seda; Daloglu, Hayriye; Celen, Safiye Suna; Hazar, VolkanBusulfan (BU)-based myeloablative conditioning is a standard conditioning regimen for children with AML; however, it is not clear yet which combination of cyclophosphamide (CY) and fludarabine (FLU) is most effective. We performed a study to compare the results of BUCY120 and BU-FLU in pediatric patients with AML in CR1 undergoing allo-HSCT from matched sibling donors. With the combination of BU, 15 patients were given 120 mg/kg of CY, and 12 patients were given 150 mg/m2 of FLU, respectively, in the condition regimen. Patients treated with BUFLU relapsed less than those treated with BUCY120 (p= 0.03). Moreover, these patients engrafted platelets earlier than the BUCY120 administered patients (p= 0.03). The frequency of complications in both groups was comparable. There was no significant difference in survival analysis between the groups. BUFLU has a low toxicity profile, making it a reasonable choice for children with AML in CR1 with low risk and a lower relapse frequency compared to BUCY120.Öğe Newborn screening for sickle cell anemia in Antalya, Türkiye(Turkish J Pediatrics, 2023) Ozturk, Zeynep; Kupesiz, O. Alphan; Karasu, Gulsun; Uygun, Vedat; Oygur, Nihal; Yesilipek, M. AkifBackground. In a screening study conducted on adults, the prevalence of sickle cell traits in Antalya was found to be 0.24%. Since no screening studies have been conducted in the neonatal period in our region, the exact incidence has not been determined. In this study, we aim to report our experience of neonatal screening for sickle cell disease in Antalya, Turkiye.Methods. During a 14-month period, 2562 heel prick blood samples, taken on filter paper from Akdeniz University Hospital, Antalya Education and Research Hospital and Antalya Ataturk State Hospital and four other healthcare centers, were studied using the high pressure liquid chromatography method. Blood samples were studied using the 'Sickle Cell Short Program' test method on a Bio Rad Variant device.Results. In the study, no patients with sickle cell disease were identified. Four newborns who were sickle cell carriers (0.15%) and two newborns who were Hemoglobin D carriers (0.08 %), were found. Conclusion.Considering the efficiency and cost calculations made as a result of the data obtained from our study, it was concluded that sickle cell screening would not be effective in newborns. It seems more effective and economical to screen the children of parents, who are found to be at risk for Hemoglobin S carriage as a result of premarital tests.Öğe PRE-TRANSPLANTATION VITAMIN D DEFICIENCY INCREASES ACUTE GRAFT-VERSUS-HOST DISEASE AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA MAJOR PATIENTS(Springernature, 2023) Uygun, Vedat; Daloglu, Hayriye; Ozturkmen, Seda; Yalcin, Koray; Karasu, Gulsun; Yesilipek, Akif[Abstract Not Available]