Yazar "Khosravi, Arezoo" seçeneğine göre listele

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    Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?
    (Royal Soc Chemistry, 2024) Khorsandi, Danial; Rezayat, Dorsa; Sezen, Serap; Ferrao, Rafaela; Khosravi, Arezoo; Zarepour, Atefeh; Khorsandi, Melika
    The application of three- and four-dimensional (3D/4D) printing in cancer research represents a significant advancement in understanding and addressing the complexities of cancer biology. 3D/4D materials provide more physiologically relevant environments compared to traditional two-dimensional models, allowing for a more accurate representation of the tumor microenvironment that enables researchers to study tumor progression, drug responses, and interactions with surrounding tissues under conditions similar to in vivo conditions. The dynamic nature of 4D materials introduces the element of time, allowing for the observation of temporal changes in cancer behavior and response to therapeutic interventions. The use of 3D/4D printing in cancer research holds great promise for advancing our understanding of the disease and improving the translation of preclinical findings to clinical applications. Accordingly, this review aims to briefly discuss 3D and 4D printing and their advantages and limitations in the field of cancer. Moreover, new techniques such as 5D/6D printing and artificial intelligence (AI) are also introduced as methods that could be used to overcome the limitations of 3D/4D printing and opened promising ways for the fast and precise diagnosis and treatment of cancer. Recent advancements pertaining to the application of 3D, 4D, 5D, and 6D bioprinting in cancer research are discussed, focusing on important challenges and future perspectives.
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    Contribution of Autophagy to Epithelial Mesenchymal Transition Induction during Cancer Progression
    (Mdpi, 2024) Strippoli, Raffaele; Niayesh-Mehr, Reyhaneh; Adelipour, Maryam; Khosravi, Arezoo; Cordani, Marco; Zarrabi, Ali; Allameh, Abdolamir
    Simple Summary This manuscript focuses on the complex relationships between autophagy and epithelial mesenchymal transition (EMT) in cancer. Autophagy, a cellular degradation process, and EMT, a mechanism where epithelial cells acquire mesenchymal features, both play significant roles in cancer development. This review aims to explore how these processes interact, particularly how autophagy impacts cancer cell fate during EMT. The findings from this study are expected to contribute to a better understanding of cancer biology and could potentially impact cancer treatment strategies, as both autophagy and EMT are considered targets for therapy.Abstract Epithelial Mesenchymal Transition (EMT) is a dedifferentiation process implicated in many physio-pathological conditions including tumor transformation. EMT is regulated by several extracellular mediators and under certain conditions it can be reversible. Autophagy is a conserved catabolic process in which intracellular components such as protein/DNA aggregates and abnormal organelles are degraded in specific lysosomes. In cancer, autophagy plays a controversial role, acting in different conditions as both a tumor suppressor and a tumor-promoting mechanism. Experimental evidence shows that deep interrelations exist between EMT and autophagy-related pathways. Although this interplay has already been analyzed in previous studies, understanding mechanisms and the translational implications of autophagy/EMT need further study. The role of autophagy in EMT is not limited to morphological changes, but activation of autophagy could be important to DNA repair/damage system, cell adhesion molecules, and cell proliferation and differentiation processes. Based on this, both autophagy and EMT and related pathways are now considered as targets for cancer therapy. In this review article, the contribution of autophagy to EMT and progression of cancer is discussed. This article also describes the multiple connections between EMT and autophagy and their implication in cancer treatment.
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    Innovative approaches for cancer treatment: graphene quantum dots for photodynamic and photothermal therapies
    (Royal Soc Chemistry, 2024) Zarepour, Atefeh; Khosravi, Arezoo; Yuecel Ayten, Necla; cakir Hatir, Pinar; Iravani, Siavash; Zarrabi, Ali
    Graphene quantum dots (GQDs) hold great promise for photodynamic and photothermal cancer therapies. Their unique properties, such as exceptional photoluminescence, photothermal conversion efficiency, and surface functionalization capabilities, make them attractive candidates for targeted cancer treatment. GQDs have a high photothermal conversion efficiency, meaning they can efficiently convert light energy into heat, leading to localized hyperthermia in tumors. By targeting the tumor site with laser irradiation, GQD-based nanosystems can induce selective cancer cell destruction while sparing healthy tissues. In photodynamic therapy, light-sensitive compounds known as photosensitizers are activated by light of specific wavelengths, generating reactive oxygen species that induce cancer cell death. GQD-based nanosystems can act as excellent photosensitizers due to their ability to absorb light across a broad spectrum; their nanoscale size allows for deeper tissue penetration, enhancing the therapeutic effect. The combination of photothermal and photodynamic therapies using GQDs holds immense potential in cancer treatment. By integrating GQDs into this combination therapy approach, researchers aim to achieve enhanced therapeutic efficacy through synergistic effects. However, biodistribution and biodegradation of GQDs within the body present a significant hurdle to overcome, as ensuring their effective delivery to the tumor site and stability during treatment is crucial for therapeutic efficacy. In addition, achieving precise targeting specificity of GQDs to cancer cells is a challenging task that requires further exploration. Moreover, improving the photothermal conversion efficiency of GQDs, controlling reactive oxygen species generation for photodynamic therapy, and evaluating their long-term biocompatibility are all areas that demand attention. Scalability and cost-effectiveness of GQD synthesis methods, as well as obtaining regulatory approval for clinical applications, are also hurdles that need to be addressed. Further exploration of GQDs in photothermal and photodynamic cancer therapies holds promise for advancements in targeted drug delivery, personalized medicine approaches, and the development of innovative combination therapies. The purpose of this review is to critically examine the current trends and advancements in the application of GQDs in photothermal and photodynamic cancer therapies, highlighting their potential benefits, advantages, and future perspectives as well as addressing the crucial challenges that need to be overcome for their practical application in targeted cancer therapy. Recent advancements pertaining to the application of GQD-based nanosystems in photothermal and photodynamic cancer therapies are discussed, highlighting crucial challenges, advantages, and future perspectives.
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    MOFs and MOF-Based Composites as Next-Generation Materials for Wound Healing and Dressings
    (Wiley-V C H Verlag Gmbh, 2024) Bigham, Ashkan; Islami, Negar; Khosravi, Arezoo; Zarepour, Atefeh; Iravani, Siavash; Zarrabi, Ali
    In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds and antimicrobial resistance. Metal-organic frameworks (MOFs) represent a promising class of materials for next-generation wound healing and dressings. Their high surface area, pore structures, stimuli-responsiveness, antibacterial properties, biocompatibility, and potential for combination therapies make them suitable for complex wound care challenges. MOF-based composites promote cell proliferation, angiogenesis, and matrix synthesis, acting as carriers for bioactive molecules and promoting tissue regeneration. They also have stimuli-responsivity, enabling photothermal therapies for skin cancer and infections. Herein, a critical analysis of the current state of research on MOFs and MOF-based composites for wound healing and dressings is provided, offering valuable insights into the potential applications, challenges, and future directions in this field. This literature review has targeted the multifunctionality nature of MOFs in wound-disease therapy and healing from different aspects and discussed the most recent advancements made in the field. In this context, the potential reader will find how the MOFs contributed to this field to yield more effective, functional, and innovative dressings and how they lead to the next generation of biomaterials for skin therapy and regeneration. Recent advancements pertaining to the applications of MOFs and their composites for wound healing and dressings are deliberated, with the purpose of identifying knowledge gaps, evaluating challenges, and guiding future directions in the field. image
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    MXene-based nano(bio)sensors for the detection of biomarkers: A move towards intelligent sensors
    (Elsevier, 2024) Khorsandi, Danial; Yang, Jia-Wei; Ulker, Zeynep; Bayraktaroglu, Kenz; Zarepour, Atefeh; Iravani, Siavash; Khosravi, Arezoo
    MXene-based nano(bio)sensors have emerged as promising tools for detecting different biomarkers. These sensors utilize MXene materials, a class of two-dimensional transition metal carbides, nitrides, and carbonitrides, to enable highly sensitive and selective detection. One of the key advantages of MXene-based materials is their high surface area, allowing for efficient immobilization of biomolecules. They also exhibit excellent electrical conductivity, enabling rapid and sensitive detection of biomarkers. The combination of high surface area and conductivity makes MXene-based sensors ideal for detecting biomarkers at low concentrations. Furthermore, MXene-based materials possess unique mechanical properties, ensuring the durability of the sensors. This durability enables repeated use without compromising the sensor performance, making MXene-based sensors suitable for continuous monitoring applications. Despite their advantages, MXene-based nano(bio)sensors face certain challenges for practical biomedical and clinical applications. One challenge lies in the synthesis of MXene materials, which can be complex and time-consuming. Developing scalable synthesis methods is crucial to enable large-scale production and widespread use of MXene-based sensors. In addition, ensuring the stability of MXene layers under various environmental conditions remains a challenge for their practical application. Another limitation is the specificity of MXene-based sensors towards targeted biomarkers. Interfering substances or crossreactivity with similar biomolecules can lead to false-positive or false-negative results. Enhancing the selectivity of MXene-based sensors through optimization and functionalization is essential to improve their reliability and accuracy. The integration of these sensors with emerging technologies, such as artificial intelligence (AI) and internet of things, opens up new possibilities in biomarker detection. The combination of MXene sensors with AI algorithms can enable real-time monitoring, remote data analysis, and personalized healthcare solutions. Herein, the significant challenges and future prospects of MXene-based nano(bio)sensors for the detection of biomarkers are deliberated. The key obstacles have been highlighted, such as ensuring the stability and biocompatibility of MXene-based sensors, as well as addressing scalability issues. The promising future prospects of these sensors have also been explored, including their potential for high sensitivity, selectivity, and rapid response.
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    Sustainable synthesis: natural processes shaping the nanocircular economy
    (Royal Soc Chemistry, 2024) Khosravi, Arezoo; Zarepour, Atefeh; Iravani, Siavash; Varma, Rajender S.; Zarrabi, Ali
    Sustainable synthesis in nano domain refers to the development of nanomaterials through deployment of natural processes and principles to minimize the use of hazardous materials and reduce the generation of waste. This method aims to mitigate the environmental impact associated with traditional synthesis methods wherein natural processes, such as biomineralization and self-assembly, offer valuable insights into the nanocircular economy (NE) thus creating numerous benefits. Firstly, it reduces the environmental footprint of nanotechnology by minimizing energy consumption and waste generation. Secondly, it promotes the efficient use of resources by incorporating principles of recycling and reusability. By mimicking natural processes, various nanomaterials can be created, which are biocompatible, biodegradable, and less harmful to the environment. However, challenges such as scale-up, cost, regulatory frameworks, and material selection ought to be addressed to ensure their widespread adoption. The prospects for sustainable synthesis in the NE are promising, with potential advancements in advanced materials, and the integration of circular economy concepts into nanomedicine, and environmental appliances; its future lies in bioinspired synthesis, adherence to green chemistry principles, waste recycling and up-cycling, energy-efficient techniques, life cycle assessment (LCA), and multi-disciplinary collaborations. This review seeks to contribute to the existing knowledge and understanding of sustainable synthesis and its impact on shaping eco-friendlier and resource-efficient NE by describing the methodology involved and discuss the benefits, challenges, and future opportunities emphasizing the importance of sustainability and responsible practices in development of nanomaterials. This perspective aims to shed light on the transformative potential of sustainable synthesis in guiding the transition towards circular economy conceptions in the nanotechnology domain.
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    Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
    (Springer, 2023) Tabatabaee, Aliye; Nafari, Behjat; Farhang, Armin; Hariri, Amirali; Khosravi, Arezoo; Zarrabi, Ali; Mirian, Mina
    This comprehensive review explores vimentin as a pivotal therapeutic target in cancer treatment, with a primary focus on mitigating metastasis and overcoming drug resistance. Vimentin, a key player in cancer progression, is intricately involved in processes such as epithelial-to-mesenchymal transition (EMT) and resistance mechanisms to standard cancer therapies. The review delves into diverse vimentin inhibition strategies. Precision tools, including antibodies and nanobodies, selectively neutralize vimentin's pro-tumorigenic effects. DNA and RNA aptamers disrupt vimentin-associated signaling pathways through their adaptable binding properties. Innovative approaches, such as vimentin-targeted vaccines and microRNAs (miRNAs), harness the immune system and post-transcriptional regulation to combat vimentin-expressing cancer cells. By dissecting vimentin inhibition strategies across these categories, this review provides a comprehensive overview of anti-vimentin therapeutics in cancer treatment. It underscores the growing recognition of vimentin as a pivotal therapeutic target in cancer and presents a diverse array of inhibitors, including antibodies, nanobodies, DNA and RNA aptamers, vaccines, and miRNAs. These multifaceted approaches hold substantial promise for tackling metastasis and overcoming drug resistance, collectively presenting new avenues for enhanced cancer therapy.