Yazar "Tatar, Burak" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Investigation of prognostic significance of CD44 expression in women with vulvar squamous cell carcinoma
    (2019) Yalçın, Yakup; Uysal, Selda; Tatar, Burak; Yavuz, And; Akkurt, Mehmet Özgür; Yiğit, Seyran
    The aim of our study is to evaluate whether CD 44 isoform expression is a prognostic factor in vulvar carcinom and to correlate the expression with clinicopathological parameters. Methods: The study included 26 patients diagnosed with invasive squamous cell vulvar cancer. The data of patients were obtained from the oncology followup records and the hospital database. The haemotoxylene & eosin stained preparates of the cases were removed from the archives and re-evaluated by examination of the slides under a light microscope. The preparates of the patients were evaluated separately according to the extent and intensity of staining and the combined score applied with the immunohistochemical method in the anti-CD44 antibody in the epithelium and the stroma. Results: When the CD44 epithelial staining intensity and staining combined scores of the patients were examined according to other clinicopathological parameters, a statistically significant difference was found between the groups in terms of tumour grade, differentiation, age, lymph node positivity, and survival rates (p<0.05). As epithelial staining increased and the combined score increased, the tumour grade and lymph node positivity were observed to increase, differentiation worsened and survival reduced. Conclusions: The identification of additional new markers to present useful prognostic factors for vulvar carcinoma is critical. Aberrant expression of CD44 mediated adhesion is likely to constitute one of the main factors leading to the reduced cell-cell and cell-matrix adhesion characteristics of tumor cells and play a pivotal role in the acquisition of invasive and metastatic properties by neoplastic epithelial cells
  • Küçük Resim
    Öğe
    The parameters to estimate postoperative severe complications classified through clavien-dindo after upper abdominal surgery in patients with primary and recurrent ovarian cancer
    (Via Medica, 2019) Yalçın, Yakup; Tatar, Burak; Erdemoğlu, Ebru; Erdemoğlu, Evrim
    Objectives: The more surgical effort and performing extensive upper abdominal surgery (UAS) are often required to accomplish the highest rates of optimally cytoreduction in patients with ovarian cancer. Nonetheless, the rate of complications increases with extensive surgery. We have studied the upper abdominal surgery complications by Clavien-Dindo Classification (CDC) and analyzed parameters affecting post-operative severe complications classified through Clavien-Dindo. Material and methods: A retrospective cohort of patients diagnosed with epithelial ovarian cancer from January 1st 2009 to April 30th 2016 was evaluated. Patients who underwent at least one UAS procedure with or without optimal cytoreduction for epithelial ovarian cancer (stage IIIC-IV or recurrent) were included. Postoperative complications were recorded according to the Clavien-Dindo Classification. Results: In total, 58 patients were included. There were 120 UAS procedures performed on the 58 patients. Diaphragm peritonectomy was the most performed surgery (50%, 29/58), and then the other UAS procedures were liver surgery (39.7%, 23/58), cholecystectomy (24.1%, 14/58), splenic surgery (24.1%, 14/58), full-thickness diaphragm resection (22.4%, 13/58), pancreatic surgery (19%, 11/58), resection of tumor from porta hepatis (17.2%, 10/58), celiac lymph node excision (8.6%, 5/58), partial gastrectomy (1.7%, 1/58), respectively.Thirteen patients (22.4%) had post-operative grade 3-5 complications according to CDC within 30 days after surgery. Conclusions: This current study demonstrated that the addition of extensive upper abdominal surgery procedures were not associated with increased postoperative severe complications in patients with recurrent or advanced ovarian cancer.These procedures are safe and feasible for patients in need and also can be performed with acceptable mortality and morbidity.