Investigation of prognostic significance of CD44 expression in women with vulvar squamous cell carcinoma

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Küçük Resim

Tarih

2019

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

The aim of our study is to evaluate whether CD 44 isoform expression is a prognostic factor in vulvar carcinom and to correlate the expression with clinicopathological parameters. Methods: The study included 26 patients diagnosed with invasive squamous cell vulvar cancer. The data of patients were obtained from the oncology followup records and the hospital database. The haemotoxylene & eosin stained preparates of the cases were removed from the archives and re-evaluated by examination of the slides under a light microscope. The preparates of the patients were evaluated separately according to the extent and intensity of staining and the combined score applied with the immunohistochemical method in the anti-CD44 antibody in the epithelium and the stroma. Results: When the CD44 epithelial staining intensity and staining combined scores of the patients were examined according to other clinicopathological parameters, a statistically significant difference was found between the groups in terms of tumour grade, differentiation, age, lymph node positivity, and survival rates (p<0.05). As epithelial staining increased and the combined score increased, the tumour grade and lymph node positivity were observed to increase, differentiation worsened and survival reduced. Conclusions: The identification of additional new markers to present useful prognostic factors for vulvar carcinoma is critical. Aberrant expression of CD44 mediated adhesion is likely to constitute one of the main factors leading to the reduced cell-cell and cell-matrix adhesion characteristics of tumor cells and play a pivotal role in the acquisition of invasive and metastatic properties by neoplastic epithelial cells

Açıklama

Anahtar Kelimeler

CD44, Expression, Vulva, Vulvar Carcinom

Kaynak

Medicine Science

WoS Q Değeri

Scopus Q Değeri

Cilt

8

Sayı

4

Künye

YALCIN Y,YALCIN S. E,UYSAL S,TATAR B,YAVUZ A,AKKURT M. O,YİGİT S (2019). Investigation of prognostic significance of CD44 expression in women with vulvar squamous cell carcinoma. Medicine Science, 8(4), 774 - 781. Doi: 10.5455/medscience.2019.08.9085