Investigation of prognostic significance of CD44 expression in women with vulvar squamous cell carcinoma

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dc.authoridYakup Yalçın / 0000-0002-8826-6481
dc.authorscopusidYakup Yalçın / 56319712900
dc.authorwosidYakup Yalçın / AAH-9761-2021
dc.contributor.authorYalçın, Yakup
dc.contributor.authorUysal, Selda
dc.contributor.authorTatar, Burak
dc.contributor.authorYavuz, And
dc.contributor.authorAkkurt, Mehmet Özgür
dc.contributor.authorYiğit, Seyran
dc.date.accessioned2020-11-23T08:58:40Z
dc.date.available2020-11-23T08:58:40Z
dc.date.issued2019en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of our study is to evaluate whether CD 44 isoform expression is a prognostic factor in vulvar carcinom and to correlate the expression with clinicopathological parameters. Methods: The study included 26 patients diagnosed with invasive squamous cell vulvar cancer. The data of patients were obtained from the oncology followup records and the hospital database. The haemotoxylene & eosin stained preparates of the cases were removed from the archives and re-evaluated by examination of the slides under a light microscope. The preparates of the patients were evaluated separately according to the extent and intensity of staining and the combined score applied with the immunohistochemical method in the anti-CD44 antibody in the epithelium and the stroma. Results: When the CD44 epithelial staining intensity and staining combined scores of the patients were examined according to other clinicopathological parameters, a statistically significant difference was found between the groups in terms of tumour grade, differentiation, age, lymph node positivity, and survival rates (p<0.05). As epithelial staining increased and the combined score increased, the tumour grade and lymph node positivity were observed to increase, differentiation worsened and survival reduced. Conclusions: The identification of additional new markers to present useful prognostic factors for vulvar carcinoma is critical. Aberrant expression of CD44 mediated adhesion is likely to constitute one of the main factors leading to the reduced cell-cell and cell-matrix adhesion characteristics of tumor cells and play a pivotal role in the acquisition of invasive and metastatic properties by neoplastic epithelial cellsen_US
dc.identifier.citationYALCIN Y,YALCIN S. E,UYSAL S,TATAR B,YAVUZ A,AKKURT M. O,YİGİT S (2019). Investigation of prognostic significance of CD44 expression in women with vulvar squamous cell carcinoma. Medicine Science, 8(4), 774 - 781. Doi: 10.5455/medscience.2019.08.9085en_US
dc.identifier.doi10.5455/medscience.2019.08.9085en_US
dc.identifier.endpage781en_US
dc.identifier.issn2147-0634en_US
dc.identifier.issn2147-0634en_US
dc.identifier.issue4en_US
dc.identifier.startpage774en_US
dc.identifier.trdizinid378902en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2019.08.9085
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1237
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorYalçın, Yakup
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCD44en_US
dc.subjectExpressionen_US
dc.subjectVulvaen_US
dc.subjectVulvar Carcinomen_US
dc.titleInvestigation of prognostic significance of CD44 expression in women with vulvar squamous cell carcinomaen_US
dc.typeArticleen_US

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