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https://hdl.handle.net/20.500.12713/4

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A rare case of multiple gastric duplication cysts in an adult
(Erkan Mor, 09.10.2024) Zulfikaroglu, Baris; Akgul, Ozgur; Ozmen, Mehmet Mahir
Intestinal duplications are rare developmental anomalies that can occur anywhere along the gastrointestinal tract. Gastric duplication cysts are uncommon congenital anomalies and are rarely diagnosed in adults. However, diagnosis of the condition in an adult can be difficult as it is usually asymptomatic, or the symptoms are nonspecific. Here we report a rare case of symptomatic gastric duplication cysts in an adult who was treated successfully with surgical resection.
Continuous Renal Replacement Therapy (CRRT) Protocol in Critically Ill Children
(Galenos Yayınevi, 24.09.2024) Koker, Alper; Yaman, Ayhan; Akkuzu, Emine; Duyu, Muhterem; Akcay, Nıhal; Dalkıran, Tahir; Besci, Tolga
Amaç: Çocuk yoğun bakım ünitelerinde sürekli renal replasman tedavisi (SRRT), şiddetli akut böbrek hasarının tedavisi ve/veya sıvı dengesi, asitbaz ve metabolik düzensizlikte sıklıkla kullanılmaktadır. Bu tedavinin uygulamasında; kateter seçiminden, kullanılan antikoagülasyon yöntemine kadar çeşitli teknik zorluklarla karşılaşılmakta ve komplikasyonlar görülebilmektedir. Bu çalışmayı yapmaktaki amacımız, SRRT endikasyonları ve komplikasyonlarını değerlendirmek, kullanılan iki farklı antikoagülasyon yöntemini karşılaştırarak deneyimlerimizi paylaşmaktır. Gereç ve Yöntem: Bu çalışmada, bir üniversite hastanesinin 3.basamak çocuk yoğun bakım ünitesinde (ÇYBÜ) Ekim 2020 ile Eylül 2021 tarihleri arasında Sürekli Renal Replasman Tedavisi uygulanan hastaların verileri geriye dönük olarak değerlendirildi. Bulgular: Hastaların ortanca yaşı 120 ay (2-204) ve 16’sı kızdı (%47,1). Sürekli renal replasman tedavisi uygulanan 22 (%64,7) hastada bölgesel sitrat antikoagülasyonu, 12 (%35,3) hastada ise heparin antikoagülan kullanıldı. SRRT endikasyonları sırasıyla, akut böbrek yetmezliği (11, %32,4), sıvı yüklenmesi (9, %26,5), metabolik asidoz /elektrolit bozukluğu (7, %20,6), tümör yıkım sendromu (5, %14,7), hiperamonyemi (1, %2,9), intoksikasyon (1, %2.9) idi. Sitrat kullanılan grupta filtre tipinden bağımsız devre ömrü ortalama 50,1±22 saat iken heparin grubunda bu süre ortalama 28,5±16,6 saat olarak bulundu (p=0,01). Serum kalsiyum düzeyi sitrat grubunda heparin grubuna göre anlamlı olarak daha yüksek tespit edildi (p=0,005). Sonuç: Bölgesel sitrat antikoagülasyon kullanımı filtre ömrünü uzatmaktadır. Bu durumun karşılaşılabilecek teknik problemleri ve iş yükünü azalttığını, maliyete belirgin katkı sağladığını düşünmekteyiz.
A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?
(İstanbul Üniversitesi Yayınevi, 2022) Eken, Hazal; Bektaş, Nurcan
Pain is sensed by the activation of painful nociceptors in the periphery or by pain mediators, such as bradykinin, serotonin, histamine, and prostaglandin, released from the damaged tissue, afferent transmission to the medulla spinalis, and by trans- mission stages to the high centers over the dorsal horn. Pain, which was seen as only a warning sign in the past, is now ac- cepted as a phenomenon in itself that needs to be treated and the search for new, stronger active substances with fewer side effects in the treatment of pain is in demand. Hydrogen sulfide (H 2S) is a modulator of T-type Ca+2 channels, especially in Cav3.2, which are known to play a critical role in the processing of pain. H2S can also show an anti-nociceptive effect by open- ing K + channels and blocking nociceptors. Exciting preclinical data has demonstrated that H2S-derived Non-steroidal anti- inflammatory drugs (NSAIDs) and analgesic agents can be used to treat various types of pain. H2S increases the resistance of gastric mucosa against injury occurred by drugs used for pain relief and accelerates its repair, so it provides an advantage to derivatized drugs. In addition, H2S donors have also been shown to induce analgesia through μ-opioid receptors. Based on the studies, it is thought that the combination of H2S with opioid receptor agonists may provide an additive or even synergistic analgesic effect. It is estimated that the modification of H2S, with currently used analgesic drugs to prevent various side ef- fects and increase analgesic effects, is a promising and wise approach.
The effect of the distance between mesh and the urethra on sexual function in patients who underwent transobturator tape
(Galenos Yayınevi, 25.11.2024) Sahin, Fatih; Doğan, Ozan
Objective: To evaluate the effect of mesh-urethra distance on sexual function in continent patients who underwent transobturator tape (TOT) surgery due to isolated stress urinary incontinence (SUI). Material and Methods: Continent patients who had undergone TOT surgery for SUI were eligible. Objective treatment for SUI was defined as the absence of urine leakage during a stress test. Translabial perineal ultrasound was performed six months after surgery. The successful surgical group was split into two subgroups based on the distance from the posterior of the urethra at the bladder neck to the nearest proximal edge of the tape: <5 mm and >5 mm. In addition to these, band percentile, the descent of bladder neck and urethra length measured by perineal ultrasound, pubo-urethral distance, urethral thickness, detrusor thickness, cystocele descent, rectal descent, and uterine descent were evaluated. Preoperative and postoperative results of the standardized and internationally valid incontinence questionnaires Incontinence Questionnaire Urinary Incontinence Short Form and Female Sexual Function Index (FSFI) were compared between groups. Results: Eighty-two patients were included. The postoperative FSFI scores for the >5 mm group were significantly lower than those of the <5 mm group, including the postoperative FSFI average, all subscales except lubrication, and average change scores due to the operation (p<0.001). There was no statistically significant relationship between the percentile occupied and postoperative FSFI score (p=0.553), and the FSFI preoperative-postoperative difference was not significant (p=0.905). Conclusion: Sexual functions are more affected in patients with a mesh-urethra distance >5 mm as measured by perineal ultrasound. (J Turk Ger Gynecol Assoc. 2024; 25: 124-31)
Capsaicin Modulates Adipocyte Cell Differentiation and Inflammatory Gene Expression
(İstanbul Üniversitesi, 03.11.2024) Degırmencıoglu, Sevgın; Çetinalp, Pınar; Küçük, Sevda Tanrıkulu; Seyithanoğlu, Muhammed; Kocak, Hikmet; Iyidogan, Yıldız Oner
Objective: Adipose tissue stores lipids necessary for the maintenance of nutritional homeostasis. It is also an endocrine organ that reacts to changes in inflammation and energy status. Capsaicin, the principal bioactive compound in red pepper, has garnered significant attention for its reported anti-obesity, anti-diabetic, anti-oxidant, and anti-inflammatory properties. In this study, we aimed to elucidate the influence and most efficacious dose of capsaicin on the expression of lipid metabolism-related inflammatory proteins and the inhibition of adipocyte cell differentiation. Materials and Methods: Cell viability analysis was performed using CCK-8, cell differentiation was assessed using Oil Red O, and gene expression levels of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer binding protein alpha (C/EBPα), adiponectin, leptin, cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), nuclear factor kappa B1 (NF-κB1), tumor necrosis factor-alpha (TNF-α), sirtuin-1 (SIRT-1), transient receptor potential vanilloid receptor 1 (TRPV1), and uncoupling protein 2 (UCP2) were evaluated using quantitative real time polymerase chain reaction (qRT-PCR). Statistical analyses were conducted using GraphPad Prism 5. One-way ANOVA was performed to compare quantitative data between the groups. Results: Capsaicin suppressed preadipocyte-to-adipocyte differentiation and mitigated the release of pro-inflammatory cytokines, particularly at low concentrations. Capsaicin effectively suppressed adiponectin levels at all concentrations but decreased leptin levels at lower concentrations (0.5 μM and 1 μM). Capsaicin stimulated the expressions of SIRT1 and TRPV-1 in adipocytes. According to our findings, the most effective capsaicin dose for the regulation of SIRT1 and TRPV-1 expressions appears to be 20 μM. Conclusion: Capsaicin’s effect on proteins regulating adipogenesis is not dose-related, but its inhibitory effect on adiposity-dependent inflammation was more pronounced at low concentrations.
The apoptotic effect of garlic (Allium sativum) derived SEVs on different types of cancer cell lines in vitro
(Tubitak scientific & technological research council Turkey, 2024) Ünsal, Naz; Koçak, Polen; Yılmaz, Hazal; Şahin, Fikrettin; Canpolat, Merve Yıldırım
Background/aim: Small extracellular vesicles (SEVs) are known to have an impact on the physiological conditions of target cells, are a critical component of cell -to -cell communication, and have been implicated in a variety of diseases. Although it has been proposed that edible plant -derived nanoparticles have an effect on communication with mammalian cells, the influence of these nanoparticles on cancer cell development has yet to be explored. Materials and methods: In order to characterize small extracellular vesicles obtained from garlic, specific SEV surface markers, antibodies, and size detections were identified using scanning electron microscopy and nanoparticle tracking analysis. Human hepatoma (Hep3B), human neuroblastoma (SH-SY5Y), human pancreatic adenocarcinoma (Panc-1a), human glioblastoma (U87), prostate cancer (PC -3), and human umbilical vein endothelial (HUVEC) cell lines were treated with garlic SEVs to examine their anticancer properties. Results: Annexin V FITC/PI staining for apoptosis, mRNA, and protein expression levels via RT-PCR and ELISA indicated that garlic SEVs triggered apoptosis by activating the intrinsic pathway. Our findings support the idea that SEVs produced from garlic may trigger apoptotic cell death in cancer cells while having no effect on healthy cells. Conclusion: It was discovered that plant SEVs had anti -cancer effects by activating caspase-mediated apoptosis.
Georg Lukacs Gerçekçiliği Üzerinden Yakup Kadri ve Ankara Romanı
(Yunus Kaplan, 11.10.2024) Gündoğdu, Mehmet Ali
Ankara’yı ilginç kılan en önemli özellik belki de yazıldığı dönemdir. Bu dönemde, Türkiye’de Cumhuriyetle beraber yeni bir rejim kurulmuş ve buna bağlı olarak belirsizliklerle dolu yeni şartlar ortaya çıkmıştır. Ayrıca yeni devrin ilkelerini halka yaymak maksadıyla Yakup Kadri’nin de aralarında olduğu Kadrocu bir hareket faaliyete başlamıştır. Kadrocu görüşlerin Ankara’ya etkilerinin oldukça yoğun olduğu açıktır. Öte yandan önceki eserlerinden bildiğimiz Yakup Kadri’nin gerçekçi, toplumcu, nesnel ve sağlam üslubunun da olgunlaştığı bir dönemde bu romanın yazıldığı düşünülürse farklı okumalara açık olduğu söylenebilir. İşte bu açıdan, Yakup Kadri’nin çağdaşı olan Georg Lukacs’ın toplumcu gerçekçi kuramının, bu romanın incelenmesine kuvvetli bir ışık tuttuğu görülmüştür. Lukacs bir taraftan “eleştirel gerçekçilik” adı altında nesnellik, tipik olma, sosyal görüş, tarihsel perspektif, somut veriler gibi ilkeleri öne çıkartırken; diğer taraftan toplumcu gerçekçiliğin uzak ve soyut hayaller uğruna ideolojik bir tutuma dönüştürülmesini “devrimci romantizm” olarak tanımlayarak eleştirmiştir. Yakup Kadri ise her ne kadar romanın ilk bölümlerinde Lukacsçı kurama göre ideal bir kurmaca yapısı ortaya koymuş olsa da son bölümde Lukacs’ın eleştirdiği tutuma yaklaşır. Makalede Yakup Kadri’nin Lukacsçı kurama göre bu iki uç arasında savrulması mukayeseli bir yöntemle ve örnekler eşliğinde anlatılmaya çalışılmıştır.
Clınıcal Results Of Percutaneous Vertebroplasty In Thoracolumbar (T6- L5) Vertebral Compressıon Fractures: Retrospectıve Study Of 111 Patıents Wıth 140 Fractured Segments
(Galenos Yayınevi, 2019) Özger, Özkan; Kaplan, Necati
Object: Vertebroplasty was first applied by Harve Deramond to a patient with vertebral hemangioma in 1984. In recent years, the increase in the number of osteoporosis, trauma and tumor cases has increased the incidence of vertebral compression fractures (VCFs). Nowadays, percutaneous vertebroplasty (PVP) has been a widely used treatment for painful acute VCFs. It is a minimally invasive technique. In this procedure, polymethylmethacrylate (PMMA) is injected into the vertebral corpus. There are PMMA’s ability to increase stability at fracture site, thermal necrosis effect and chemotoxic effect on intra-osseous pain receptors. In this study, the safety and efficacy of PVP in patients with VCF were evaluated. Methods: The patients who underwent PVP under sedoanalgesia or general anesthesia for single or multi-level thoracolumbar vertebrae fracture were reviewed retrospectively between January 2012 and March 2018. The study included 111 patients with VCF. 140 vertebral levels were treated with PVP. These VCFs were evaluated in 3 groups as osteoporotic, traumatic and pathological. We used the Oswestry Disability Index (ODI) for functional disability and the Visual Analog Scale (VAS) for pain severity. Our patients were followed up for 12 month after PVP. Results: Patients mean age was 73,04 ± 7,17 years (91-56 years) and 18 (16,22 %) were male and 93 (83,78 %) were female. The most commonly affected vertebrae were T12 and L1 vertebrae corpus. Following PVP, VAS and ODI values decreased significantly in the last 12 months compared to preoperative levels (p<.001). Cement leakage was occurred in six patients (5.40 %). Conclusions: PVP is an advantageous method. Because the procedure is fast and easy, a biopsy can be taken during the procedure, patients can soon stand up and be discharged; its complications are much less than open surgery. In addition to general anesthesia, it can be performed with sedoanalgesia. It is a reliable and effective technique for the treatment of pain due to osteoporotic and traumatic VCFs or metastatic lesions.
Comparison of Patients’ Compliances, Tolerances, and Experiences of Different Colonoscopic Bowel Preparation Agents: A Prospective Observational Study
(Galenos Yayınevi, 07.08.2024) Alkan, Şendağ; Şahin, Sennur Kula
Aim: Patients’ compliance and tolerance in terms of bowel cleansing agents and quality of bowel cleansing are important for a successful colonoscopy procedure. Method: This is a prospective observational study that was conducted to compare the compliances, tolerances, and experiences of patients in whom polyethylene glycol (PEG), macrogol, and sennoside + enema agents were used for bowel cleansing before colonoscopy. The sample was composed of a total of 159 patients who received PEG (n=53), macrogol (n=53), and sennoside + enema (n=53) in the endoscopy unit in a university hospital in the province of Adana between March 1, 2020, and July 15, 2020. The “Descriptive Characteristics Form”, which was developed by the researchers, and the “Colonoscopy Patient Assessment Form” and “Colonoscopy Procedure Assessment Form,” which interrogated compliance, tolerance, and bowel cleansing quality and the patients’ experiences, were used for data collection. Results: In this study, compliance (p=0.115), bowel cleansing qualities (p=0.827), and experiences (p>0.05) were found to be similar in the patients in the three groups. However, it was found that the patients in the sennoside + enema group developed intolerance including nausea (p=0.039), vomiting (p=0.045), and malaise and fatigue (p=0.042) to a greater extent and needed more help (p<0.001) compared with the patients in the macrogol and PEG groups. Half of the patients (47.3%) described the bowel preparation for colonoscopy as tiring and wearing. Conclusion: Sufficient bowel cleansing was provided with all three bowel cleansing agents used before colonoscopy in this study. The patients tolerated the PEG solution better than the sennoside + enema and macrogol agents. Comprehensive prospective randomized studies with large sample sizes are needed to better evaluate the effect of bowel cleansing agents and to help patients have a more comfortable colonoscopy procedure.
Changes in the bioactivity of einkorn wheat during the maturation period and their effect on the properties of einkorn bread
(TÜBİTAK, 28.10.2024) Erkölencik, Mehmet Fatih; Kahraman, Burcu; Ozulku, Gorkem; Tulukcu, Eray; Goktas, Hamza; Sagdıc, Osman; Arıcı, Muhammet
Immature cereals may contain higher levels of nutrients than mature cereals. Immature and mature einkorn wheats were compared in terms of physicochemical, technological, rheological, and nutritional qualities and their performances for making bread were revealed. The values for thousand grain weight, hectoliter weight, sedimentation value and falling number of immature and mature einkorn wheat samples were 23.25–32.29 (g), 72.32–79.11 (kg/hL), 15.02–18.07 (mL) and 312–341 (sec), respectively (p ≤ 0.05). Immature einkorn wholegrain flour (IEWF) contains more than twofold mineral substance than mature einkorn wholegrain flour (MEWF). The total phenolic content and antioxidant properties of IEWF were found to be higher than those of MEWF. The empirical rheological properties of IEWF were higher than those of MEWF except for degree of softening . The G′ of both IEWF and MEWF were always found higher than the G′′, so they exhibited elastic behavior. The crust color brightness values of breads made from IEWF and MEWF were significantly different from bread made from commercial wheat wholegrain flour (CWF), but similar values were obtained for crumb color. The overall acceptability score of IEWF bread was similar to CWF bread, thus IEWF could be a good candidate for bread making or use in different food formulations.
Central line-associated bloodstream infection outbreak related to Ralstonia pickettii-contaminated saline in a pediatric hematopoietic stem cell transplant center
(Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü, 17.10.2024) Çelen, Safiye Suna; Zhumatayev, Suleimen; Yalçın, Koray; Kara, Emine Manolya; Sutcu, Murat; Karasu, Gulsun; Yesilipek, M.Akif
Background. Ralstonia pickettii is an aerobic Gram-negative non-fermentative bacillus. It is an opportunistic pathogen that has recently prompted nosocomial outbreaks. Although it has low virulence, it can cause a wide range of invasive diseases in immunosuppressive patients. The characteristics of R. pickettii-related central line-associated bloodstream infection (CLABSI) outbreak in pediatric hematopoietic stem cell transplant (HSCT) recipients are presented in this study. Materials and Methods. This was a single-center, retrospective analysis conducted at Bahcesehir University Goztepe Medicalpark Hospital . The clinical and laboratory characteristics of twelve children with Ralstonia-related CLABSIs were analyzed. Results. Of the twelve patients with R. pickettii growth, seven were female. The median age was 12.1 (2-17) years. Autologous HSCT was performed in two of the patients and allogeneic HSCT was performed in ten patients for both malignant and non-malignant diseases. In the conditioning regimens, all patients were given myeloablative therapy. Clinical sepsis was the most common presentation. As a result of the investigations, R. pickettii growth was observed in saline solutions. All cases were successfully treated with the appropriate antibiotic regimen and the bacteria was not found in repeat cultures. Catheter removal was required in two patients. Mortality was not observed in any patient as the outcome of the infection episode. Conclusion. The detection and control of the infectious source are critical in pediatric HSCT patients with severe immunosuppression, as medical equipment-related outbreaks can be life-threatening.
Alpha-lipoic acid intoxication in an adolescent girl:Case report and review of the literature
(Alpay Azap, 2020) Polat, Sinem; Kılıçaslan, Önder; Sönmez, Feruza Turan
Alpha-lipoic acid is a widely used medication that does not need a prescription. Although it is safely used in adults, hitherto no safe dose for children has been reported, and there is no known antidote. The medical literature provides four reports of alpha-lipoic acid intoxication in the pediatric population to date. This case-report is the lowest known dose of alpha-lipoic acid intake leading to poisoning in a teenager.
Akut Lenfoblastik Lösemili Çocuklarda Hematopoetik Kök Hücre Nakli: Tek Merkez Deneyimi
(İzmir Bozyaka Eğitim ve Araştırma Hastanesi, 24.07.2024) Daloglu, Hayriye; Uygun, Vedat; Öztürkmen, Seda; Karasu, Gülsün; Yeşilipek, Akif
Giriş: Çocuklarda yüksek riskli akut lenfoblastik lösemide (ALL), remisyon sağlandıktan sonra, hematopoetik kök hücre nakli (HKHN) ile kür sa ğlanabilmektedir. Ancak HKHN, nakil ilişkili toksisite ve mortalite riski de taşımaktadır. Çal ışmamızda merkezimizde ALL nedeniyle HKHN uygulanmış hastaların uzun süreli sağ kalım sonuçları sunulmuştur. Gereç ve Yöntem: ALL tanısı ile HKHN uygulanmış 135 hastanın klinik verileri retrospektif olarak incelendi. TR1 ve TR2 ́de olan hastalara ilk kez uygulanan nakiller tarandı, refrakter hastalar çal ışmaya alınmadı. Nakil sonrası toksisite, enfeksiyon ve graft versus host hastalığı (GVHH) açısından komplikasyonlar ve sağkalım kaydedildi. Bulgular: Hastaların 86’sına busulfan (BU) ve 49’una total vücut ışınlaması (TBI) içeren hazırlık rejimi uygulandı. Hastaların %47 ́sinde ağır mukozit görüldü ve bu durum TBI alanlarda daha sık saptandı. Gram pozitif ve negatif enfeksiyonlarla eşit sıklıkta karşılaşılırken, hastaların %30’unda viral enfeksiyonlar saptandı. Yüksek evre GVHH açısından bakıldığında, sırasıyla %26 ve %24 hastada yüksek evre akut GVHH (evre3-4) ve kronik GVHH (orta- ağır) gözlendi. HKHN sonrası ortanca 19 ay izlem sürecinde 26 hastanın öldüğü (%19) ve 33 hastada (%24) ortanca 5 ayda relaps geliştiği görüldü. Tüm sağkalım (OS) (7 yıllık) %78.4, olaysız sağkalım (EFS) %62.3 olarak saptandı (OS TR1 için %90.1, TR2 için %70.4 (p=0.02); EFS TR1 için %80.3, TR2 için %50.8 (p<0.01)). Sonuç: Çalışmamız, pediatrik ALL hastalarında TR1 ve TR2 ́de uygulanan HKHN sonrası sağkalımın, donör tipinden bağımsız olarak, literatür ile kar şılaştırıldığında sadece kemoterapi ile tedavi edilmiş hastalara oranla daha iyi olduğunu ve nakil sonrası komplikasyonlar aç ısından kabul edilebilir bir toksisite ile sonuçlandığını göstermektedir. TR2 ́de TR1 ́e göre sa ğkalımın daha düşük olması nedeniyle, sa ğkalımı arttırmak için, seçilmiş hasta gruplarına minimal kal ıntı hastalığı ve donör durumuna bağlı olarak endikasyonların belirlenmesi ve daha erken HKHN uygulanması önerilebilir.
Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience
(İstanbul Üniversitesi, 12.09.2024) Uysalol, Ezgi Paslı; Bayram, Cengiz; Özdemir, Nihal; Tekgündüz, Sibel Akpınar; Aydoğan, Gönül; Ayçiçek, Ali
Objective: Acute lymphoblastic leukemia (ALL) is one of the most common malignant diseases in children. This study aimed to determine the clinical and prognostic characteristics of adolescent patients with ALL aged 15–18 years who were followed up in our center. Materials and Methods: The clinical and laboratory characteristics, treatment responses, and survival and relapse rates of adolescent patients with ALL were retrospectively analyzed Results: The majority of patients were male. The median age of patients was 16 (range 15–17.9) years. About 36% and 74% of patients were diagnosed with T- and B-cell ALLs, respectively. Then, 32% of patients were stratified in the high-risk group. BCR/ABL t (9;22) positivity was detected in one patient. Recurrence was observed in 6 of 31 patients after completing the treatment. The estimated survival rate in the high-risk group at 32 months was 58%. Conclusion: Ihe prognosis and outcomes of ALL in adolescent and young adult patients are poor compared to younger age groups. Future clinical trials and advance in chemotherapeutic protocols in this age group will help increase the treatment success rates.
A worldwide bibliometric analysis on euthanasia
(SERNEV Ar-Ge Yazılım Yayıncılık Eğitim Danışmanlık ve Organizasyon Ticaret Limited Şirketi, 18.11.2024) Güdük, Özden
Introduction: Euthanasia, which allows individuals with an incurable disease to end their lives in an honourable way, is a long-debated practice. It is related to various issues such as culture, philosophy, religion, ethics, public value, and efficient use of health resources. While some advocate for the right of individuals to choose euthanasia, others criticize it on ethical, legal, and religious grounds. Methods: In this study bibliometric analysis was used and the data were obtained from the Web of Science Core Collection database on July 26, 2024. Only English publications and articles were included using keywords such as "euthanasia," "end-of-life decisions," "medical assistance in dying," "physician-assisted death," and "physician-assisted suicide" without time restrictions. VOSviewer software was used to create network and density graphs, and SciMAT software was used to create strategic diagrams. Results: A total of 2,230 studies published between 1980 and 2024 were analyzed. The author with the most publications is Deliens, L, with 86 studies. The majority of studies were published in the USA, Netherlands, and Canada (692, 336, 225 respectively). The most frequently used keywords are euthanasia, palliative care, and ethics. The highest number of publications (149) was in the year 2021. In the strategic diagram for the first period (between 1980 and 2001), the themes of care and ethics were prominent, while for the second period (between 2002 and 2024), the clusters of nurse and shared decision-making were notable. Conclusion: After its legalization in the Netherlands, euthanasia has been accepted and implemented in some countries over the years, with variations in scope. Some countries, like the Netherlands and Belgium, also accept health problems related to old age and mental illness as euthanasia requests. The discussion around euthanasia often revolves around the principles of medical ethics, including autonomy, beneficence, non-maleficence, and justice. Studies have focused on the role of physicians and nurses in the process, as well as end-of-life decision-making by patients. Recently, Canada defined the role of nurses in the euthanasia process, marking a significant development.
A theoretical framework on embodiment in digital design
(Mehmet Topçu, 2024) Erdem, Arzu; Asut, Serdar
This article presents a theoretical discussion on the need for developing digital design environments that can strengthen our relations with the tangible, tacit, and implicit dimensions of design cognition. It synthesizes relevant concepts and theories in the field of phenomenology, addressing creative design thinking. It suggests that designer's tacit ways of knowing can be accommodated in digital design practices by developing tools that allow intuitive and embodied interactions. To this end, it points out specific concepts, methods, and theories within Human-Computer Interaction (HCI) research, arguing that they can enable the development of better digital design tools that can cope with complex human perceptual mechanisms, including touch, as an extension of both body and mind, and that can encompass the implicit areas inherent in design knowledge. Therefore, concerning the creative design disciplines, it highlights the importance of closely following the findings of research within HCI that are relevant to design knowledge and its implementation.
Current Induction Therapy Strategies and Anti-T Lymphocyte Globulin Usage in Kidney Transplantation: Consensus-Based Recommendations by a Turkish Expert Panel
(AVES Yayıncılık, 04.10.2024) Cakir, Ulkem; Dınckan, Ayhan; Karadoğan, Nayim; Keven, Kenan; Koçak, Hüseyin; Koç, Serkan Kubilay; Sezer, Siren; Töz, Hüseyin; Turkmen, Aydin; Usalan, Celalettin; Yıldız, Alaattın
This advisory committee convened to review national and global kidney transplantation dynamics and provide recom- mendations on the use of anti-T lymphocyte globulin (ATLG) for prevention and treatment of rejection after allogeneic kidney transplantation. A critical evaluation of 6 relevant articles released up to October 2022 was performed to reveal their importance in clinical practice. Additionally, 27 key questions on the indication, dosage of ATLG, and risk stratification were used for the Delphi technique with 8 members of the Turkish Society of Nephrology including 5 kidney transplanta- tion (KTx) subcommittee members and a surgeon experienced in solid organ transplantation. The committee declared that Türkiye had great potential in KTx; however, increase in transplantation would be possible in the case of raise in the deceased donor transplantation. As a consensus, ATLG was strongly recommended for induction and rejection treatment. Also, committee members recommended the safe dosage range in steroid resistant acute rejection as 2.5-3 mg/kg daily for 5-7 days, and the median of preferred dosage in induction sounded as 2-2.5 mg/kg daily for 3 days in intermediate risk state. Additionally, post-transplant infection and malignancy cases due to immunosuppression were much rarely encoun- tered than they were in the past.
Developing University Students Coping Skills with Academic Procrastination Behavior: A Cognitive Behavioral Theory Based Psychoeducation Practice
(Tamer Kutluca, 14.05.2024) Tolan, Özlem
In our journal’s Volume 11 Issue 22, the heading of the PDF article in the study of Özlem ÇAKMAK TOLAN named as “Developing university students coping skills with academic procrastination behavior: A cognitive behavioral theory-based psychoeducation practice” published in the 2023 issue of the Journal of Computer and Education Research, Volume 11, Issue 22, there is a paragraph that was not written inadvertently. The paragraph that was not written by mistake and was requested to be added is located on page 734 under the heading "Process". “In the study, a psychoeducational program based on cognitive-behavioral therapy for coping with academic procrastination was used. In the program, which was implemented to raise awareness about academic procrastination behavior in university students and to reduce it, the studies of Kağan (2010) and Toker (2014) were used as the main guide. As a result of the author's application to our journal dated December 13, 2023, the correction notification regarding the addition of the missing paragraph should be as follows. According to this, the addition of the missing paragraph the Özlem ÇAKMAK TOLAN’s article will be add “In the study, a psychoeducational program based on cognitive-behavioral therapy for coping with academic procrastination was used. In the program, which was implemented to raise awareness about academic procrastination behavior in university students and to reduce it, the studies of Kağan (2010) and Toker (2014) were used as the main guide.” In Volume 11, Issue 22, under the title "The Process" on page 734.
Destructiveness: An Inner Drive of the Human Nature or a Fact of the Social Structure?
(Mustafa Çevik, 2018) Kahraman, Ömer Ersin
According to natural sciences, destructivity is related to the competitive state of the natural selection. In this sense, nature is considered like a battlefield where all creatures only seek for their own survival in an unending rivalry. However, that perception of nature was not invented by natural sciences insofar as this pseudo-reality of universal conflict was already present in philosophy as a reflection of the social structure of the 16th and 17th centuries. Scientists borrowed that vision of nature as they observed the social structure in which they lived as universal and the state of war as an undeniable fact. This article aims to raise the question about the influence of political philosophy on the scientific paradigm and to understand the political and social source of destructiveness.
Effect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats
(TÜBİTAK, 23.10.2024) İsmayılzade, Majid; İnce, Bilsev; Oltulu, Pembe; Baycar, Zikrullah; Kendir, Münür Selçuk; Dadaci, Mehmet
Background/aim: In the literature, almost all of the nerve conduits proposed for obtaining better nerve recovery were applied as graft materials. In this study, we aimed to propose a new nerve conduit model with a flap pattern and evaluate the effect of a pedicled vascularized jejunal flap on nerve regeneration after wrapping it around a sciatic nerve. Materials and methods: A total of 90 Wistar albino rats were randomly divided into nine groups with 10 rats in each. The first three groups constituted the control groups, whereas Groups 4–6 were the jejunum conduit (JC)-applied groups. A mucosa-resected JC (MRJC) was applied in Groups 7 and 8. Epineurial neurorrhaphy was performed in Groups 1, 4, and 7; repair with a nerve graft was applied in Groups 2, 5, and 8; and a 1-cm-long nerve defect was created in Groups 3, 6, and 9. After 2 months of follow-up, nerve regeneration was assessed by statistical analyses of the Sciatic Functional Index (SFI) and histopathological evaluation. Results: The MRJC groups had significantly better results in terms of SFI (p = 0.005). Statistical differences in axonal degeneration, axonal density, myelination, and disorganization were found between all control groups and MRJC groups (p = 0.022, p = 0.001, p = 0.001, and p = 0.039, respectively). Conclusion: In this study, the feasibility of wrapping around the nerve repair zones of pedicled autologous flaps designed in a tubular fashion was observed in a small rat model. The findings must be further validated with larger animals before clinical testing.

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