Effect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats
Küçük Resim Yok
Tarih
23.10.2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TÜBİTAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: In the literature, almost all of the nerve conduits proposed for obtaining better nerve recovery were applied as graft materials. In this study, we aimed to propose a new nerve conduit model with a flap pattern and evaluate the effect of a pedicled vascularized jejunal flap on nerve regeneration after wrapping it around a sciatic nerve. Materials and methods: A total of 90 Wistar albino rats were randomly divided into nine groups with 10 rats in each. The first three groups constituted the control groups, whereas Groups 4–6 were the jejunum conduit (JC)-applied groups. A mucosa-resected JC (MRJC) was applied in Groups 7 and 8. Epineurial neurorrhaphy was performed in Groups 1, 4, and 7; repair with a nerve graft was applied in Groups 2, 5, and 8; and a 1-cm-long nerve defect was created in Groups 3, 6, and 9. After 2 months of follow-up, nerve regeneration was assessed by statistical analyses of the Sciatic Functional Index (SFI) and histopathological evaluation. Results: The MRJC groups had significantly better results in terms of SFI (p = 0.005). Statistical differences in axonal degeneration, axonal density, myelination, and disorganization were found between all control groups and MRJC groups (p = 0.022, p = 0.001, p = 0.001, and p = 0.039, respectively). Conclusion: In this study, the feasibility of wrapping around the nerve repair zones of pedicled autologous flaps designed in a tubular fashion was observed in a small rat model. The findings must be further validated with larger animals before clinical testing.
Açıklama
Anahtar Kelimeler
autologous conduit flap., Jejunum conduit flap, peripheral nerve regeneration, vascularized conduit
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
54
Sayı
4
Künye
İSMAYILZADE, M., INCE, B., OLTULU, P., BAYCAR, Z., KENDIR, M. S., DADACI, M. (2024). Effect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats. Turkish Journal of Medical Sciences , 54(4), 792 - 803. doi.org/10.55730/1300-0144.5851
