Effect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats

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dc.authoridMajid İsmayılzade / 0000-0002-6869-1333
dc.authoridBilsev İnce / 0000-0002-1756-4131
dc.authoridPembe Oltulu / 0000-0003-3273-671X
dc.authoridZikrullah Baycar / 0000-0003-4208-5201
dc.authoridMünür Selçuk Kendir / 0000-0001-7394-0907
dc.authoridMehmet Dadaci / 0000-0001-6918-1389
dc.authorscopusidMajid İsmayılzade / 57205628273
dc.authorwosidMajid İsmayılzade / AAV-1420-2020
dc.contributor.authorİsmayılzade, Majid
dc.contributor.authorİnce, Bilsev
dc.contributor.authorOltulu, Pembe
dc.contributor.authorBaycar, Zikrullah
dc.contributor.authorKendir, Münür Selçuk
dc.contributor.authorDadaci, Mehmet
dc.date.accessioned2025-04-18T09:27:47Z
dc.date.available2025-04-18T09:27:47Z
dc.date.issued23.10.2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBackground/aim: In the literature, almost all of the nerve conduits proposed for obtaining better nerve recovery were applied as graft materials. In this study, we aimed to propose a new nerve conduit model with a flap pattern and evaluate the effect of a pedicled vascularized jejunal flap on nerve regeneration after wrapping it around a sciatic nerve. Materials and methods: A total of 90 Wistar albino rats were randomly divided into nine groups with 10 rats in each. The first three groups constituted the control groups, whereas Groups 4–6 were the jejunum conduit (JC)-applied groups. A mucosa-resected JC (MRJC) was applied in Groups 7 and 8. Epineurial neurorrhaphy was performed in Groups 1, 4, and 7; repair with a nerve graft was applied in Groups 2, 5, and 8; and a 1-cm-long nerve defect was created in Groups 3, 6, and 9. After 2 months of follow-up, nerve regeneration was assessed by statistical analyses of the Sciatic Functional Index (SFI) and histopathological evaluation. Results: The MRJC groups had significantly better results in terms of SFI (p = 0.005). Statistical differences in axonal degeneration, axonal density, myelination, and disorganization were found between all control groups and MRJC groups (p = 0.022, p = 0.001, p = 0.001, and p = 0.039, respectively). Conclusion: In this study, the feasibility of wrapping around the nerve repair zones of pedicled autologous flaps designed in a tubular fashion was observed in a small rat model. The findings must be further validated with larger animals before clinical testing.
dc.identifier.citationİSMAYILZADE, M., INCE, B., OLTULU, P., BAYCAR, Z., KENDIR, M. S., DADACI, M. (2024). Effect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats. Turkish Journal of Medical Sciences , 54(4), 792 - 803. doi.org/10.55730/1300-0144.5851
dc.identifier.doi10.55730/1300-0144.5851
dc.identifier.endpage803
dc.identifier.issn1300-0144
dc.identifier.issue4
dc.identifier.pmid39295602
dc.identifier.scopus2-s2.0-85203711643
dc.identifier.scopusqualityQ1
dc.identifier.startpage792
dc.identifier.trdizinid1259915
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1259915/effect-of-vascularized-jejunal-conduit-flap-on-peripheral-nerve-regeneration-in-rats
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5851
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6797
dc.identifier.volume54
dc.identifier.wosWOS:001308289100023
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorİsmayılzade, Majid
dc.institutionauthoridMajid İsmayılzade / 0000-0002-6869-1333
dc.language.isoen
dc.publisherTÜBİTAK
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectautologous conduit flap.
dc.subjectJejunum conduit flap
dc.subjectperipheral nerve regeneration
dc.subjectvascularized conduit
dc.titleEffect of vascularized jejunal conduit flap on peripheral nerve regeneration in rats
dc.typeArticle

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