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Öğe Antiamoebic properties of ceftriaxone and zinc-oxide-cyclodextrin-conjugated ceftriaxone(MDPI, 2022) Makhlouf, Zinb; Akbar, Noor; Khan, Naveed Ahmed; Shah, Muhammad Raza; Alharbi, Ahmad M.; Alfahemi, Hasan; Siddiqui, RuqaiyyahAcanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent. Accordingly, there is a pressing need for novel compounds. Nanotechnology has been gaining attention for enhancing drug delivery and reducing toxicity. Previous work has shown that various antibiotic classes displayed antiamoebic activity. Herein, we employed two antibiotics: ampicillin and ceftriaxone, conjugated with the nanocarrier zinc oxide and beta-cyclodextrin, and tested them against A. castellanii via amoebicidal, amoebistatic, encystment, excystment, cytopathogenicity, and cytotoxicity assays at a concentration of 100 mu g/mL. Notably, zinc oxide beta-cyclodextrin ceftriaxone significantly inhibited A. castellanii growth and cytopathogenicity. Additionally, both zinc oxide beta-cyclodextrin ceftriaxone and ceftriaxone markedly inhibited A. castellanii encystment. Furthermore, all the tested compounds displayed negligible cytotoxicity. However, minimal anti-excystment or amoebicidal effects were observed for the compounds. Accordingly, this novel nanoconjugation should be employed in further studies in hope of discovering novel anti-Acanthamoeba compounds.Öğe Treatment of isolated zygomatic arch fractures with the gillies method(Springer, 2023) Çil, YakupGillies method is widely used for zygomatic arch fractures. Many modifications were suggested over time but Gillies method is still carry on popularity. Seventeen patients with isolated zygomatic arch fractures who were treated with Gillies method between 2016 and 2021 were included in this study. All patients were male and the mean age was 23 years (20-32). All operations were performed under sedation anesthesia. All patients healed uneventfully. Only one transient frontal branch of facial nerve paralysis was seen in the follow-up. Etiology of zygomatic arc fractures were sports injury in 9 patients (53%), motorcycle accident in 3 patients (17.6%), assault in 3 patients (17.6), and sencop in 2 patients (11.7%). Zygomatic arch fractures were located on left zygomatic arch in 13 patients (76.5%), right zygomatic arch in 4 patients (23.5%). Eleven patients (64.7%) were operated in 1 week and 6 patients were operated on the second week (35.3%) after the injury. We think that Gillies method is still very useful in the treatment of isolated zygomatic arch fractures.Öğe Postoperative pulmonary complications after percutaneous nephrolithotomy under spinal anesthesia(2022) Kara, Burak; Önem, Kadir; Çetinkaya, Mehmet; Açıkgöz, AbdullahPurpose: To evaluate risk factors and outcomes of Pulmonary Complications (PCs) in Percutaneous Nephrolithotomy (PCNL) under Spinal anesthesia (SA). Material and method: 286 patients who underwent PCNL under SA between 2017 and 2021 were identified retrospectively and divided into group 1 (clinically significant PCs) and group 2 (no clinically significant PCs). Demographic, preoperative, and intraoperative variables and postoperative outcomes were compared between both groups. Independent risk factors for PCs were evaluated by univariable and multivariable logistic regression analyses. Results: PCs were noted in 90 patients (31.5%). Advanced age (P = .011), high body mass index (BMI) (P < .001), and the presence of chronic obstructive pulmonary disease (COPD) (P < .001) were risk factors for PCs. Conclusion: SA is an effective method of anesthesia for all PCNL patients and carries a lower rate of PCNL-associated PCs. Risk factors for PCs after PCNL were advanced age, obesity, and preoperative COPD.Öğe Effectiveness of ozone-oxygen mixture by ultrasonography-guided facet medial branch block in the treatment of cervicogenic dizziness(Wolters Kluwer Medknow Publications, 2022) Yılmaz, Mahmut Sinan; Demir, Gürkan; Kocayi?it, Havva; E?ilmez, O?uz Kadir; Beyaz, Serbülent GökhanPurpose: Among many central and peripheral causes of vertigo, one of the factors whose pathophysiology is not yet understood is cervicogenic dizziness (CD). There are studies reporting that CD may benefit from facet joint medial bundle branch block (MBB). The purpose of our study was to share our experiences of MBB application using ultrasonography (USG) in patients diagnosed with CD. Materials and Methods: After physical examination and necessary cervical imaging, C1, C2 and C3 cervical facet joint MBB and ozone injection were performed using USG for patients who had vertigo and accompanying cervical pathology and neck pain. In order to evaluate the effectiveness of the treatment, pain levels with the Visual Analog Scale (VAS) and the effect of vertigo on the quality of life with the 'Dizziness Handicap Inventory (DHI)' Turkish validation questionnaire were documented. Results: Thirty-five patients who met the criteria were included in the study. The mean age of the patients was 50.8 ± 10.7. Of the 35 patients, 10 (28.6%) were male and 25 (71.4%) were female. There was a significant difference between the preoperative period and the postoperative 1 st, 2 nd, and 6 th week VAS scores. A significant difference was found between the preoperative and the postoperative 2 nd and 6 th week DHI questionnaire survey results as well. Conclusions: In the follow-up after the procedures, it was observed that vertigo complaints of the patients decreased significantly. © 2022 Indian Journal of Otology | Published by Wolters Kluwer - Medknow.Öğe Effect of microgravity on the gut microbiota bacterial composition in a hindlimb unloading model(MDPI, 2022) Siddiqui, Ruqaiyyah; Qaisar, Rizwan; Khan, Naveed Ahmed; Alharbi, Ahmad M.; Alfahemi, Hasan; Elmoselhi, AdelWe utilised a ground-based microgravity hindlimb unloading (HU) mouse model to elucidate the gut microbiota bacterial changes in mice under a simulated microgravity environment. Four-month-old, male C57/Bl6 mice were randomly divided into ground-based controls and the HU groups and kept under controlled environmental conditions. For the microgravity environment, the mice were suspended in special cages individually for 20 days. At the end of the suspension, the mice were sacrificed; gut dissections were performed, followed by a metagenomic analysis of bacterial species, which was carried out by extracting DNA and 16S rRNA analysis. The results revealed that the gut bacterial communities of mice under gravity and microgravity were different. Notably, our findings revealed differences in the bacterial community structure. Around 449 bacterial OTUs were specific to mice kept under normal gravity versus 443 bacterial OTUs under microgravity conditions. In contrast, 694 bacterial OTUs were common to both groups. When the relative abundance of taxa was analyzed, Bacteroidetes dominated the gut (64.7%) of normal mice. Conversely, mice in the microgravity environment were dominated by Firmicutes (42.7%), and the relative abundance of Bacteroidetes differed significantly between the two groups (p < 0.05). The distribution of Muribaculaceae between normal mice versus microgravity mice was significantly different, at 62% and 36.4%, respectively (p < 0.05). Furthermore, a significant decrease in 11 bacteria was observed in mice under simulated microgravity, including Akkermansia muciniphila, Eubacterium coprostanoligenes, Bacteroides acidifaciens, Clostridium leptum, Methylorubrum extorquens, Comamonas testosterone, Desulfovibrio fairfieldensis, Bacteroides coprocola, Aerococcus urinaeequi, Helicobacter hepaticus, and Burkholderiales. Further studies are needed to elucidate gut bacterial metabolites of these identified bacterial species in microgravity conditions and normal environment. Notably, the influence of these metabolites on obesity, neuroprotection, musculoskeletal and cardiovascular dysfunction, longevity, inflammation, health, and disease in astronauts ought to be investigated and will be important in developing procedures against adverse effects in astronauts following space travel.Öğe Recombinant FSH versus highly purified urinary FSH in patients with polycystic ovary syndrome undergoing ICSI cycles: a prospective randomized study(Galenos, 2022) Aynıoğlu, Öner; Ceylan, Yasin; Akar, Bertan; Özkan, Sabiha; Çalışkan, ErayObjective: To compare efficacy and safety of recombinant follicule stimulating hormone (r-FSH) and highly purified urinary FSH (HP-uFSH) in polycystic ovary syndrome (PCOS) patients undergoing intracytoplasmic sperm injection (ICSI). Method: This was a prospective randomized study conducted at Kocaeli University Faculty of Medicine, Department of Obstetrics and Gynecology, in vitro fertizilization (IVF) Unit. A total of 91 PCOS patients undergoing ICSI were randomly assigned to receive either r-FSH (n = 46) or HPuFSH (n = 45) with a gonadotropin releasing hormone (GnRH) antagonist protocol. The main outcome measures were the number of mature oocytes retrieved, embryo quality, pregnancy rates, implantation rates. Results: The number of mature oocytes retrieved, fertilization rates, the number of cryopreserved embryos were significantly higher in r-FSH group (p = 0.024, p = 0.023, p = 0.026 respectively) while the total dose of FSH used was significantly lower in the same group (p = 0.023). Pregnancy rates, clinical pregnancy rates were higher in r-FSH group although not statistically significant (52.2% versus 35.6%, p = 0.11, 37% versus 28.9%, p = 0.41 respectively). Overall therapy costs per clinical pregnancy were associated with a 9.94% increase in r-FSH group whereas costs per pregnancy were not different between groups. Conclusion: r-FSH is superior than HP-uFSH in PCOS regarding fertilization rates, the number of mature oocytes retrieved and cryopreserved embryos, pregnancy rates although overall therapy costs per clinical pregnancy are higher. Keywords: ART, HP-uFSH, PCOS, rec-FSH Amac: ICSI uygulanan PCOS hastalarinda rekombinant FSH (r-FSH) ve yuksek oranda saflastirilmis uriner FSH'nin (HP-uFSH) etkinligini ve guvenligini karsilastirmaktir. Yontem: Kocaeli Universitesi Tip Fakultesi Kadin Hastaliklari ve Dogum Anabilim Dali Tup Bebek Unitesi'nde yurutulen prospektif randomize bir calismadir. ICSI uygulanan toplam 91 PCOS hastasi, bir GnRH antagonist protokolu ile r-FSH (n = 46) ve HP-uFSH (n = 45) almak uzere rastgele belirlendi. Ana sonuc olcutleri; alinan olgun oosit sayisi, embriyo kalitesi, gebelik oranlari, implantasyon oranlariydi. Bulgular: Alinan olgun oosit sayisi, dollenme oranlari, dondurularak saklanan embriyo sayisi r-FSH grubunda anlamli olarak daha yuksek (sirasiyla p = 0,024, p = 0,023, p = 0,026), ayni grupta kullanilan toplam FSH dozu ise anlamli olarak daha dusuktu (p = 0,023). Gebelik oranlari, klinik gebelik oranlari r-FSH grubunda istatistiksel olarak anlamli olmamakla birlikte daha yuksekti (sirasiyla %52,2'ye karsi %35,6, p = 0,11, %37'ye karsi %28,9, p = 0,41). Klinik gebelik basina genel tedavi maliyetleri, r-FSH grubunda %9,94'luk bir artisla iliskilendirilirken, gebelik basina maliyetler gruplar arasinda farkli degildi. Sonuc: r-FSH, PCOS'de fertilizasyon oranlari, alinan olgun oosit sayisi ve dondurularak saklanan embriyolar, gebelik oranlari acisindan HP-uFSH'den ustundur, ancak klinik gebelik basina genel tedavi maliyetleri daha yuksektir. Anahtar kelimeler: ART, HP-uFSH, PCOS, rec-FSHÖğe Humoral and cellular immune response to SARS-CoV-2 mRNA BNT162b2 vaccine in pediatric kidney transplant recipients compared with dialysis patients and healthy children(SPRINGER, 2022) Gülmez, Rüveyda; Özbey, Doğukan; Ağbaş, Ayşe; Aksu, Bağdagül; Yıldız, Nurdan; Üçkardeş, Diana; Taşdemir, MehmetBackground: Compared with the general population, the immune response to COVID-19 mRNA vaccines is lower in adult kidney transplant recipients (KTRs). However, data is limited for pediatric KTRs. In this study, we aimed to assess humoral and cellular immune responses to the COVID-19 mRNA vaccine in pediatric KTRs. Methods: This multicenter, prospective, case-control study included 63 KTRs (37 male, aged 12-21 years), 19 dialysis patients, and 19 controls. Humoral (anti-SARS-CoV2 IgG, neutralizing Ab (nAb)) and cellular (interferon-gamma release assay (IGRA)) immune responses were assessed at least one month after two doses of BNT162b2 mRNA vaccine. Results: Among COVID-19 naïve KTRs (n = 46), 76.1% tested positive for anti-SARS-CoV-2 IgG, 54.3% for nAb, and 63% for IGRA. Serum levels of anti-SARS-CoV-2 IgG and nAb activity were significantly lower in KTRs compared to dialysis and control groups (p < 0.05 for all). Seropositivity in KTRs was independently associated with shorter transplant duration (p = 0.005), and higher eGFR (p = 0.007). IGRA titer was significantly lower than dialysis patients (p = 0.009). Twenty (43.4%) KTRs were positive for all immune parameters. Only four of 11 seronegative KTRs were IGRA-positive. COVID-19 recovered KTRs had significantly higher anti-SARS-CoV-2 IgG and nAb activity levels than COVID-19 naïve KTRs (p = 0.018 and p = 0.007, respectively). Conclusions: The humoral and cellular immune responses to SARS-CoV-2 mRNA BNT162b2 vaccine are lower in pediatric KTRs compared to dialysis patients. Further prospective studies are required to demonstrate the clinical efficacy of the mRNA vaccine in KTRs. This prospective study was registered in ClinicalTrials.gov (NCT05465863, registered retrospectively at 20.07.2022). A higher resolution version of the Graphical abstract is available as Supplementary information.Öğe Cockroaches: a potential source of novel bioactive molecule(s) for the benefit of human health(SPRINGER, 2022) Siddiqui, Ruqaiyyah; Yara Elmashak; Khan, Naveed AhmedCockroaches are one of the hardiest insects that have survived on this planet for millions of years. They thrive in unhygienic environments, are able to survive without food for up to 30 days, without air for around 45 min and being submerged under water for 30 min. Cockroaches are omnivorous and feed on a variety of foods, including cellulose and plastic, to name a few. It is intriguing that cockroaches are able to endure and flourish under conditions that are harmful to Homo sapiens. Given the importance of the gut microbiome on its' host physiology, we postulate that the cockroach gut microbiome and/or its metabolites, may be contributing to their "hardiness", which should be utilized for the discovery of biologically active molecules for the benefit of human health. Herein, we discuss the biology, diet/habitat of cockroaches, composition of gut microbiome, cellular senescence, and resistance to infectious diseases and cancer. Furthermore, current knowledge of the genome and epigenome of these remarkable species is considered. Being one of the most successful and diverse insects, as well as their extensive use in traditional and Chinese medicine, the lysates/extracts and gut microbial metabolites of cockroaches may offer a worthy resource for novel bioactive molecule(s) of therapeutic potential for the benefit of human health and may be potentially used as probiotics.Öğe Interleukin-21 and interleukin-32 gene expression levels and their relationship with clinicopathological parameters in colorectal cancer(EDIZIONI LUIGI POZZI, 2022) Özmen, Füsun; Erdem, Gizem Övgü; Kulaçoğlu, Sezer; Özmen, Mehmet Mahir; Kansu, EminBACKGROUND AND AIMS: The immune cells in tumor microenvironment release chemokines and cytokines which determine the immune phenotype of the tumor and play an important role in the prognosis. Present study evaluates the gene expression levels of IL -21 and IL -32 and their relations to clinicopathologic parameters in colorectal cancer. PATIENTS AND METHODS: 31(17F) patients with colorectal cancer were included. Samples were obtained from normal and tumor tissues. After RNA isolation, IL -21 and IL -32 gene expression levels were measured. Immunohistochemistry was also carried out for CD4+, CD8+ and NKcells to measure cell density. The relations between expression levels, immune cell density and diffrentiation, stage, presence of vascular, perineural invasion and lymph node metastasis(MLN) were investigated. RESULTS: IL -32 gene expression levels were increased in tumor tissues. IL -21 levels were found to be decreased in 50% of the patients. IL -32 levels were also increased with the stage however, it was decreased significantly with the increased number of the MLIV. On the other hand, expression levels of IL -21 increased significantly with the presence of vascular invasion. CD4+ density was decreased with increased T-stage, vascular invasion whereas CD8+ density decreased only with the vascular invasion. CONCLUSIONS: IL -32 expressed by tumor microenvironment reveals that expression increased to control tumor growth, but levels are decreased with the increased number of MLNs which might be due to decreased CD4+ cell density. Changes on IL -21 and IL -32 together with the changes on immune cell density, indicate their role in tumor growth and invasion in colon cancer.Öğe Acousto-holographic reconstruction of whole-cell stiffness maps(Nature Research, 2022) Varol, Rahmetullah; Karavelioğlu, Zeynep; Ömeroğlu, Sevde; Aydemir, Gizem; Karadağ, Aslıhan; Meco, Hanife E.; Demirçalı, Ali A.; Yılmaz, Abdurrahim; Koçal, Gizem C.; Gençoğlan, Gülsüm; Oruç, Muhammed E.; Esmer, Gökhan B.; Başbınar, Yasemin; Özdemir, Şahin K.; Üvet, HüseyinAccurate assessment of cell stiffness distribution is essential due to the critical role of cell mechanobiology in regulation of vital cellular processes like proliferation, adhesion, migration, and motility. Stiffness provides critical information in understanding onset and progress of various diseases, including metastasis and differentiation of cancer. Atomic force microscopy and optical trapping set the gold standard in stiffness measurements. However, their widespread use has been hampered with long processing times, unreliable contact point determination, physical damage to cells, and unsuitability for multiple cell analysis. Here, we demonstrate a simple, fast, label-free, and high-resolution technique using acoustic stimulation and holographic imaging to reconstruct stiffness maps of single cells. We used this acousto-holographic method to determine stiffness maps of HCT116 and CTC-mimicking HCT116 cells and differentiate between them. Our system would enable widespread use of whole-cell stiffness measurements in clinical and research settings for cancer studies, disease modeling, drug testing, and diagnostics. © 2022, The Author(s).Öğe Application of the free-style brachial artery perforator based propellar flap in the management of axillary hidradenitis suppurativa(WILEY, 2022) Datlı, Aslı; Demirel, OğuzhanHidradenitis suppurativa (HS) is a chronic and recurrent inflammatory disease often requiring surgical intervention in extensive lesions. Total of seven axillary lesion with HS was treated with free-style perforator based propeller flaps (innominate perforator originating from the brachial artery) after complete excision. The flap design mimicked the axis and design of the brachioplasty surgery. The flaps were elevated and after obliterating the defect, the remnant flap was discarded and donor site was primarily closed. All flaps were performed successfully and HS did not recur in any of the patients. In addition, the operated limb also showed a reduction of arm circumference of more than 5 cm. This is the first report using the free-style perforator based propeller flap to reconstruct the axillary HS. It is a simple and a reliable approach yielding good functional and aesthetic outcome with additional advantages of providing a brachioplasty.Öğe Gender differences in work-life balance of European neurosurgeons(Elsevier Ltd., 2022) Lambrianou, Xanthoula; Tzerefos,Christos; Janssen, Insa K; Mihaylova, Stiliana; Aydın,Ayşegül Esen; Al-Ahmad, Selma; Broekman, Marike Ld; Gazioğlu, Nurperi; Duran, Silvia Hernandez; Ivan, Daniela Luminita; Karampouga, Maria; Magnadottir, Hulda B; Pajaj ,Ermira; Rodríguez-Hernández, Ana; Rosseau, Gail; Salokorpi, Niina; Tsianaka, Eleni; Vayssiere, Pia; Murphy, Mary; Tasiou, AnastasiaGender differences in work-life balance of European neurosurgeonsÖğe Adli tıbbi sürece yansıyan femur-humerus kırığı saptanan yenidoğanların retrospektif değerlendirilmesi: tanımlayıcı çalışma(Turkiye Klinikleri J Foren Sci Leg Med., 2022) Yıldız Silahlı,Nicel; Aslıyüksek, Hızır; Dikici,Fatih; Celkan, Tülin TirajeAmaç: Doğum travmaları, doğum eylemi esnasında mekanik etkiler ile ortaya çıkan fiziksel yaralanmalardır. Doğum sırasında karşılaşılan bu durum medikolegal sorunlara neden olmaktadır. Çalışmamızda, yenidoğan döneminde uzun kemik kırığı saptanarak medikolegal sürece konu olmuş olguların özelliklerinin tartışılması amaçlanmıştır. Gereç ve Yöntemler: Adli Tıp Kurumu 7. İhtisas Kurulunda 2018-2020 yılları arasında medikolegal değerlendirme yapılan uzun kemik (femur/humerus) kırığı geliştiği iddiası bulunan olgular (n=23) dâhil edildi. Olguların sosyodemografik ve klinik özellikleri ile kurul kararları retrospektif olarak incelendi. Çalışma izni 01 Aralık 2020 tarih ve 1114 sayılı Adli Tıp Kurumu Bilimsel Araştırma Komisyonundan alındı. Bulgular: Olguların kız/erkek oranı 8/15 idi. On sekiz (%78,2) raporda hekim şikâyeti vardı. Olgularda femur (n=14) ve humerus (n=9) kırıkları saptandı. Olguların gestasyon haftası ortalaması 33 idi. Olguların ortalama doğum tartıları 2.921 (750-5.140 g) g saptandı. Olguların, term/preterm oranı 18/5 saptandı. Humerus ve femur kırığı saptanan 23 olguda da konservatif tedavi uygulanmıştı. Yirmi iki olguda tıbbi uygulama hatası saptanmadı ve kırıklar komplikasyon olarak değerlendirildi. Sonuç: Medikolegal sürece yansıyan uzun kemik kırıklarının tanı ve takip sürecinin uygun şekilde yönetildiği görülmektedir. Süreçte hasta-hekim arasında yaşanan iletişim sorunlarının güven ilişkisini sarstığı görülmektedir. Tıbbi bakım ve tedavi sırasında meydana gelen ve direkt olarak hekimin hatalı bir eylemi sonucu oluşmayan bu durum doğum süreci açısından komplikasyon olarak tanımlanmaktadır.Öğe Imidazothiazole derivatives exhibited potent effects against brain-eating amoebae(MDPI, 2022) Siddiqui, Ruqaiyyah; El-Gamal, Mohammed, I; Boghossian, Anania; Saeed, Balsam Qubais; Oh, Chang-Hyun; Abdel-Maksoud, Mohammed S.; Alharbi, Ahmad M.; Alfahemi, Hasan; Khan, Naveed AhmedNaegleria fowleri (N. fowleri) is a free-living, unicellular, opportunistic protist responsible for the fatal central nervous system infection, primary amoebic meningoencephalitis (PAM). Given the increase in temperatures due to global warming and climate change, it is estimated that the cases of PAM are on the rise. However, there is a current lack of awareness and effective drugs, meaning there is an urgent need to develop new therapeutic drugs. In this study, the target compounds were synthesized and tested for their anti-amoebic properties against N. fowleri. Most compounds exhibited significant amoebicidal effects against N. fowleri; for example, 1h, 1j, and 1q reduced N. fowleri's viability to 15.14%, 17.45% and 28.78%, respectively. Furthermore, the majority of the compounds showed reductions in amoeba-mediated host death. Of interest are the compounds 1f, 1k, and 1v, as they were capable of reducing the amoeba-mediated host cell death to 52.3%, 51%, and 56.9% from 100%, respectively. Additionally, these compounds exhibit amoebicidal properties as well; they were found to decrease N. fowleri's viability to 26.41%, 27.39%, and 24.13% from 100%, respectively. Moreover, the MIC50 values for 1e, 1f, and 1h were determined to be 48.45 mu M, 60.87 mu M, and 50.96 mu M, respectively. Additionally, the majority of compounds were found to exhibit limited cytotoxicity, except for 1l, 1o, 1p, 1m, 1c, 1b, 1zb, 1z, 1y, and 1x, which exhibited negligible toxicity. It is anticipated that these compounds may be developed further as effective treatments against these devastating infections due to brain-eating amoebae.Öğe Hepatic portal venous gas does not show the severity of intestinal ischaemia(PAKISTAN MEDICAL ASSOC, 2022) Yıldırım, Kadir; Karabıçak, İlhan; Gürsel, Mahmut Fikret; Öztürk, Bahadır; Malazgirt, ZaferHepatic portomesenteric venous gas is a rare condition. Although a CT scan can show hepatic portal vein gas, the intestine's condition can still be misdiagnosed at the very early stage. Accordingly, the decision to operate has to be made based on or after a physicial examnination and laboratory results. In this report, we present a case of portomesenteric venous gas in which the gas was no longer discernible on the control CT scan, even though the patient developed peritonitis.Öğe Ciliated muconodular papillary tumor masked by COVID-19 infection and aspergilloma(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2022) Coşgun, Tuğba; Zeren, Handan; Kocatürk, CelalettinNovel coronavirus disease-2019 (COVID-19) continues to pose a threat all over the world with the effect of new variants. The frequency of other secondary infections such as aspergilloma in patients with COVID-19 disease is not uncommon. Extremely rare lesions such as ciliated muconodular papillary tumor can be masked by radiological images caused by COVID-19 infection or secondary pathologies associated with it, leading to difficulties in diagnosis. Herein, we report a case in whom a diagnosis of aspergilloma and ciliated muconodular papillary tumor after six months of COVID-19 infection was made.Öğe The importance of early diagnosis and tumor size in testicular cancers(GALENOS YAYINCILIK, 2022) Sarıer, MehmetThe importance of early diagnosis and tumor size in testicular cancersÖğe Comparison of the radiological parameters between dynamic-referencing tactile guidance robotic system and microplasty (r) instrumentation in unicompartmental knee arthroplasty(TURKISH JOINT DISEASES FOUNDATION, 2022) Çabuk, Haluk; Turan, Kaya; Muratoğlu, Osman Görkem; Ergün, Tuğrul; Öztürk, Çağatay; Ertürer, Ramazan ErdenObjectives: This study aims to compare the radiological outcomes of unicompartmental knee arthroplasty (UKA) performed by a navigation-based robotic system versus Microplasty (R) instrumentation. Patients and methods: Between January 2018 and January 2019, a total of 90 knees of 75 patients (65 males, 10 females; mean age: 62.0 +/- 9.4 years; range, 50 to 73 years) were included. Among these, 54 knees underwent Oxford mobile-bearing UKA with an Microplasty (R) instrumentation set and 36 knees were operated with the aid of a Restoris (R) MCK with MAKO navigation-based robotic system. Postoperative anteroposterior and lateral X-rays of all patients were evaluated according to nine different parameters. On the femoral side, femoral varus-valgus angle, flexion-extension angle, femoral condyle posterior fit; on tibial side, tibial component varus/valgus, tibial posterior slope, medial, anterior, posterior and lateral fit of tibial component assessed. Results: There was no significant difference between groups in terms of age, sex, and affected side. On the femoral side, no significant difference was observed in the component position between groups. On the tibial side, tibial component medial fit (p=0.032) and anterior fit (p=0.007) were better in navigation-based robotic system group. Conclusion: Microplasty (R) instrumentation may lead to comparable implant positioning compared to a tactile-based navigated robotic instrumentation.Öğe Short-term outcomes of three different surgical practices in lumbar disc herniation(NOBEL ILAC, 2022) Kaptan, Hülagü; Kasımcan, Mustafa Ömür; Yılmaz, MuratObjective: Many surgical protocols are used for surgical treatment of lumbar disc herniation. Here, we discussed the postoperative short-term outcomes of patients with lumbar disc herniation who underwent three different surgical protocols. Material and Method: This study included patients who underwent simple discectomy, microdiscectomy, and discectomy+implantapproaches to treat lumbar disc herniation. We then compared patient demographics, lumbar segment, and the duration of postoperative hospital stay between the three procedures. Results: There were no statistically significant differences between the simple discectomy and implant groups in terms of the visual analogue pain scale (VAS) and Oswestry disability index (ODI) results (p > 0.05). Themicrodiscectomy group also had the best Oswestry disability index results for the third month compared with other groups (p < 0.05). Conclusion: The microdiscectomy group was the most advantageous in terms of VAS score, Oswestry scale and duration of hospital stay. As microdiscectomy is a minimally invasive procedure, it is the preferred method for the surgical management of lumbar disc herniation.Öğe Efficient extraction of methylene blue from aqueous solution using phosphine-based deep eutectic solvents with carboxylic acid(2022) Hassan, Muhammad Faheem; Khan, Amir Sada; Akbar, Noor; İbrahim, Taleb Hassan; Khamis, Mustafa I.Methylene blue (MB), an organic thiazine dye, has numerous industrial and medical applications. However, MB is a wastewater contaminant that is harmful to humans and aquatic life. Hence, its removal from water bodies is essential. In this work, five novel deep eutectic solvents (DESs) were synthesized using different precursors, screened, and studied for the extraction of methylene blue (MB) from aqueous solution using liquid-liquid extraction. The first, TOP-SA, was synthesized using trioctylphosphine (TOP) as a hydrogen bond acceptor (HBA) and 2-hydroxy benzoic acid as a hydrogen bond donor (HBD). Among these, TOP-SA had the highest MB removal efficiency. The effects of pH, contact time, initial MB concentration, volumetric ratio, temperature, and ionic strength were studied and optimized. A 99.3% removal was achieved in 5 min for a 200 mg dm(-3) MB solution mixed in a 1:10 ratio with TOP-SA at 25.0 degrees C. The structural properties of TOP-SA and its interactions with MB were investigated using FTIR. TOP-SA's toxicity was investigated using human cells in vitro. TOP-SA was found to be comparatively less toxic and is a more efficient MB remover than other literature reported ionic liquids (ILs).
