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    The effect of fundectomy on histopathological findings and metabolic hormones in rats
    (Edizioni Luigi Pozzi, 2023) Bugdayci, Nihat; Aktokmakyan, Talar Vartanoglu; Tokocin, Merve; Meric, Serhat; Ercan, Gulcin; Kirankaya, Aysegul; Cay, Tugce
    The effect of fundectomy on histopathological findings and metabolic hormones in rats AIM: Fundectomy, shown as an alternative to restrictive techniques, causes absorption restriction and metabolic changes. This study aimed to examine the histopathological changes caused by the fundectomy as a technique applied to rats by hormones that affect stomach and obesity metabolism and its effect on weight loss. MATERIAL AND METHODS: 2randomly selected Winstar-Hannover rat groups were evaluated by measuring their pre-and postoperative weights and biochemically measuring Gastrin, Ghrelin, and Leptin levels on day 30. After sacrifi cation, the stomachs were taken for histopathological examination. RESULTS: Significant weight loss was observed in the fundectomy group in the 1stmonth postoperatively. Biochemically, Gastrin means in the fundectomy group were statistically significantly higher than in the control group. The mean Ghrelin and Leptin levels of the Fundectomy Group were statistically significantly lower (p=0.005). Immunohistochemically, Gastrin means TMat the antrum and proximal stomach parts of the Fundectomy Group were significantly higher than in the control group. As Ghrelin, a significant decrease was observed in all 3regions of the Fundectomy Group compared to the control group. Leptin results were significantly lower at the antrum and proximal stomach parts of the Fundectomy Group. Histopathologically, in the Fundectomy Group, cystic glandular hyperplasia was moderate at the proximal stomach, foveolar hyperplasia was mild at the antrum, fibrosis was moderate at the antrum and corpus, and high at the proximal stomach. CONCLUSION: Fundectomy is an effective method in terms of weight loss. This animal experiment, conducted as a pilot study, will be an essential step in elucidating metabolic and histopathological changes.
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    The Effect of Single Anastomosis Duodenoileal Bypass plus Sleeve Gastrectomy on Histopathological Findings and Metabolic Hormones in Obese Rats
    (Mary Ann Liebert, Inc, 2023) Tokocin, Merve; Aktokmakyan, Talar Vartanoglu; Tokocin, Onur; Bugdayci, Nihat; Cay, Tugce; Gunes, Aysegul; Solmaz, Ali
    Purpose: Single anastomosis duodenoileal bypass+sleeve gastrectomy (SADI-S) is one of the techniques with the effect of both restrictive and absorption reduction and a more up-to-date and safer modification of this highly effective surgery. In the SADI-S model performed on rats, we aim to identify mediators in obesity and stomach metabolism, histopathologic data, and the weight loss rate.Methods: Obese rats were divided into two groups, eight of them in the SADI-S group and eight in the control group. Both groups were measured for gastrin, ghrelin, and leptin levels before and 30 days after surgery and histopathologically examined.Results: In the SADI-S group, the decrease in blood ghrelin and leptin levels was statistically significant compared with the control group (p = 0.012 and p = 0.008). The blood gastrin level was found to increase significantly compared with the control group (p = 0.012). The decrease in levels of ghrelin and leptin, determined histopathologically, in the SADI-S group was statistically significant compared with the control group (p = 0.015 and p = 0.003). The increase in gastrin level was found to be statistically significant compared with the control group (p = 0.001). Histopathological examination revealed a statistically significant increase in foveolar hyperplasia (FH) and cystic glandular dilation (CGD) in the SADI-S group (p = 0.003 and p = 0).Conclusions: In our experimental model, SADI-S was found to be a more effective method for weight loss, compared with the control group, and development of CGD, which has the potential for coexistence with gastric cancer, was detected with FH.