The Effect of Single Anastomosis Duodenoileal Bypass plus Sleeve Gastrectomy on Histopathological Findings and Metabolic Hormones in Obese Rats
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mary Ann Liebert, Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Single anastomosis duodenoileal bypass+sleeve gastrectomy (SADI-S) is one of the techniques with the effect of both restrictive and absorption reduction and a more up-to-date and safer modification of this highly effective surgery. In the SADI-S model performed on rats, we aim to identify mediators in obesity and stomach metabolism, histopathologic data, and the weight loss rate.Methods: Obese rats were divided into two groups, eight of them in the SADI-S group and eight in the control group. Both groups were measured for gastrin, ghrelin, and leptin levels before and 30 days after surgery and histopathologically examined.Results: In the SADI-S group, the decrease in blood ghrelin and leptin levels was statistically significant compared with the control group (p = 0.012 and p = 0.008). The blood gastrin level was found to increase significantly compared with the control group (p = 0.012). The decrease in levels of ghrelin and leptin, determined histopathologically, in the SADI-S group was statistically significant compared with the control group (p = 0.015 and p = 0.003). The increase in gastrin level was found to be statistically significant compared with the control group (p = 0.001). Histopathological examination revealed a statistically significant increase in foveolar hyperplasia (FH) and cystic glandular dilation (CGD) in the SADI-S group (p = 0.003 and p = 0).Conclusions: In our experimental model, SADI-S was found to be a more effective method for weight loss, compared with the control group, and development of CGD, which has the potential for coexistence with gastric cancer, was detected with FH.
Açıklama
Anahtar Kelimeler
Bariatric Surgery, Obesity, Sadi-S
Kaynak
Bariatric Surgical Practice and Patient Care
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
