The Effect of Single Anastomosis Duodenoileal Bypass plus Sleeve Gastrectomy on Histopathological Findings and Metabolic Hormones in Obese Rats

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dc.authoridVartanoglu Aktokmakyan, Talar/0000-0003-0583-6440
dc.authorwosidVartanoglu Aktokmakyan, Talar/AFI-3036-2022
dc.contributor.authorTokocin, Merve
dc.contributor.authorAktokmakyan, Talar Vartanoglu
dc.contributor.authorTokocin, Onur
dc.contributor.authorBugdayci, Nihat
dc.contributor.authorCay, Tugce
dc.contributor.authorGunes, Aysegul
dc.contributor.authorSolmaz, Ali
dc.date.accessioned2024-05-19T14:39:17Z
dc.date.available2024-05-19T14:39:17Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPurpose: Single anastomosis duodenoileal bypass+sleeve gastrectomy (SADI-S) is one of the techniques with the effect of both restrictive and absorption reduction and a more up-to-date and safer modification of this highly effective surgery. In the SADI-S model performed on rats, we aim to identify mediators in obesity and stomach metabolism, histopathologic data, and the weight loss rate.Methods: Obese rats were divided into two groups, eight of them in the SADI-S group and eight in the control group. Both groups were measured for gastrin, ghrelin, and leptin levels before and 30 days after surgery and histopathologically examined.Results: In the SADI-S group, the decrease in blood ghrelin and leptin levels was statistically significant compared with the control group (p = 0.012 and p = 0.008). The blood gastrin level was found to increase significantly compared with the control group (p = 0.012). The decrease in levels of ghrelin and leptin, determined histopathologically, in the SADI-S group was statistically significant compared with the control group (p = 0.015 and p = 0.003). The increase in gastrin level was found to be statistically significant compared with the control group (p = 0.001). Histopathological examination revealed a statistically significant increase in foveolar hyperplasia (FH) and cystic glandular dilation (CGD) in the SADI-S group (p = 0.003 and p = 0).Conclusions: In our experimental model, SADI-S was found to be a more effective method for weight loss, compared with the control group, and development of CGD, which has the potential for coexistence with gastric cancer, was detected with FH.en_US
dc.identifier.doi10.1089/bari.2023.0014
dc.identifier.issn2168-023X
dc.identifier.issn2168-0248
dc.identifier.scopus2-s2.0-85171299452en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1089/bari.2023.0014
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4744
dc.identifier.wosWOS:001139387400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofBariatric Surgical Practice and Patient Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBariatric Surgeryen_US
dc.subjectObesityen_US
dc.subjectSadi-Sen_US
dc.titleThe Effect of Single Anastomosis Duodenoileal Bypass plus Sleeve Gastrectomy on Histopathological Findings and Metabolic Hormones in Obese Ratsen_US
dc.typeArticleen_US

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