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    Distribution of ?-actinin-3 rs1815739 and angiotensin-1 converting enzyme indel polymorphisms in Turkish bodybuilders
    (Spandidos Publications, 2020) Polat, Tolga; Doğan, Canan Sercan; Doğan, Murat; Akçay, Teoman; Ulucan, Korkut
    The determination of the genetic profiles of successful athletes and the effects of these genetic parameters on athletic performance is gaining increasing interest. The majority of studies assessing the genetics of athletes usually analyse the most well-known genetic variations in athletes associated with the different specialties. The aim of the present study was to analyse the ACE InDel and ACTN3 rs1815739 polymorphisms in Turkish bodybuilders. A total of 11 male bodybuilders were recruited and genotyped for these polymorphisms. The respective percentage of the ACE II, ID and DD genotypes were 18, 73 and 9. For the ACTN3 genotype, the respective frequencies were 55 and 45 for the RX and RR genotypes. No XX genotype was detected. The allelic counts were 12 (55%) for I and 10 (45%) for the D alleles of ACE; and 12 (55%) and 10 (45%) for R and X alleles, respectively, for the ACTN3 genotype. Additionally, 5 athletes had ID + RX genotypes in terms of ACE InDel and ACTN3 rs1815739 polymorphisms, respectively. These results indicate the importance of endurance related alleles of ACE and ACTN3 in bodybuilders. The results of the present are in agreement with previous studies, highlighting a potential association between specific polymorphisms and the endurance-related nature of bodybuilders. Further studies with larger cohorts are required to understand the association between these polymorphisms and specific parameters performance in bodybuilders.
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    Multivitamin with L-Arginine supplementation can increase linear growth velocity in children with idiopathic short stature without affecting bone maturation
    (MATTIOLI 1885, 2020) Akçagil, Ömer; Ulucan, Korkut; Akçay, Teoman
    L-arginine is a well-known growth hormone (GH) stimulator. The aim of the present study was to investigate the effect of L-arginine supplementation on growth velocity in prepubertal boys with idiopathic short stature. In this retrospectively designed study, prepubertal boys over 5 years of age who were diagnosed with idiopathic short stature were randomized into two groups according to their use of multivitamin with arginine (ARGIVIT (R)) (n=24) or multivitamin without arginine (n=34). Both groups were compared statistically according to growth velocity, IGF-1 and IGF-BP3 SDS and bone age maturation rates before and after 1 year of treatment. Basal IGF-1 SDS and basal IGF-BP3 SDS values of the groups were similar, but after the mean 1-year treatment, IGF-1 and IGFBP3 SDS values of the study group increased significantly compared to the control group. The annual growth velocity of the study group also showed a statistically significant increase compared to the control group. There was no statistical difference between the two groups in terms of bone maturation. L-arginine supplementation can be an inexpensive, safe and effective treatment alternative in idiopathic short stature.