Multivitamin with L-Arginine supplementation can increase linear growth velocity in children with idiopathic short stature without affecting bone maturation
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MATTIOLI 1885
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
L-arginine is a well-known growth hormone (GH) stimulator. The aim of the present study was to investigate the effect of L-arginine supplementation on growth velocity in prepubertal boys with idiopathic short stature. In this retrospectively designed study, prepubertal boys over 5 years of age who were diagnosed with idiopathic short stature were randomized into two groups according to their use of multivitamin with arginine (ARGIVIT (R)) (n=24) or multivitamin without arginine (n=34). Both groups were compared statistically according to growth velocity, IGF-1 and IGF-BP3 SDS and bone age maturation rates before and after 1 year of treatment. Basal IGF-1 SDS and basal IGF-BP3 SDS values of the groups were similar, but after the mean 1-year treatment, IGF-1 and IGFBP3 SDS values of the study group increased significantly compared to the control group. The annual growth velocity of the study group also showed a statistically significant increase compared to the control group. There was no statistical difference between the two groups in terms of bone maturation. L-arginine supplementation can be an inexpensive, safe and effective treatment alternative in idiopathic short stature.
Açıklama
Anahtar Kelimeler
Idiopathic Short Stature, L-arginine Supplementation, Growth Velocity
Kaynak
PROGRESS IN NUTRITION
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
22
Sayı
4
Künye
Akcagil, O., Ulucan, K., Akcay, T., (2020). PROGRESS IN NUTRITION, 22(4)
