Multivitamin with L-Arginine supplementation can increase linear growth velocity in children with idiopathic short stature without affecting bone maturation

Yükleniyor...
Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

MATTIOLI 1885

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

L-arginine is a well-known growth hormone (GH) stimulator. The aim of the present study was to investigate the effect of L-arginine supplementation on growth velocity in prepubertal boys with idiopathic short stature. In this retrospectively designed study, prepubertal boys over 5 years of age who were diagnosed with idiopathic short stature were randomized into two groups according to their use of multivitamin with arginine (ARGIVIT (R)) (n=24) or multivitamin without arginine (n=34). Both groups were compared statistically according to growth velocity, IGF-1 and IGF-BP3 SDS and bone age maturation rates before and after 1 year of treatment. Basal IGF-1 SDS and basal IGF-BP3 SDS values of the groups were similar, but after the mean 1-year treatment, IGF-1 and IGFBP3 SDS values of the study group increased significantly compared to the control group. The annual growth velocity of the study group also showed a statistically significant increase compared to the control group. There was no statistical difference between the two groups in terms of bone maturation. L-arginine supplementation can be an inexpensive, safe and effective treatment alternative in idiopathic short stature.

Açıklama

Anahtar Kelimeler

Idiopathic Short Stature, L-arginine Supplementation, Growth Velocity

Kaynak

PROGRESS IN NUTRITION

WoS Q Değeri

Q4

Scopus Q Değeri

Q4

Cilt

22

Sayı

4

Künye

Akcagil, O., Ulucan, K., Akcay, T., (2020). PROGRESS IN NUTRITION, 22(4)