Multivitamin with L-Arginine supplementation can increase linear growth velocity in children with idiopathic short stature without affecting bone maturation

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dc.authoridTeoman Akçay / 0000-0002-8252-7089
dc.authorscopusidTeoman Akçay / 23968688000
dc.authorwosidTeoman Akçay / AFG-8460-2022
dc.contributor.authorAkçagil, Ömer
dc.contributor.authorUlucan, Korkut
dc.contributor.authorAkçay, Teoman
dc.date.accessioned2021-02-10T11:15:56Z
dc.date.available2021-02-10T11:15:56Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractL-arginine is a well-known growth hormone (GH) stimulator. The aim of the present study was to investigate the effect of L-arginine supplementation on growth velocity in prepubertal boys with idiopathic short stature. In this retrospectively designed study, prepubertal boys over 5 years of age who were diagnosed with idiopathic short stature were randomized into two groups according to their use of multivitamin with arginine (ARGIVIT (R)) (n=24) or multivitamin without arginine (n=34). Both groups were compared statistically according to growth velocity, IGF-1 and IGF-BP3 SDS and bone age maturation rates before and after 1 year of treatment. Basal IGF-1 SDS and basal IGF-BP3 SDS values of the groups were similar, but after the mean 1-year treatment, IGF-1 and IGFBP3 SDS values of the study group increased significantly compared to the control group. The annual growth velocity of the study group also showed a statistically significant increase compared to the control group. There was no statistical difference between the two groups in terms of bone maturation. L-arginine supplementation can be an inexpensive, safe and effective treatment alternative in idiopathic short stature.en_US
dc.identifier.citationAkcagil, O., Ulucan, K., Akcay, T., (2020). PROGRESS IN NUTRITION, 22(4)en_US
dc.identifier.doi10.23751/pn.v22i4.10652en_US
dc.identifier.issn1129-8723en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85103276672en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.23751/pn.v22i4.10652
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1448
dc.identifier.volume22en_US
dc.identifier.wosWOS:000607282500011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAkçay, Teoman
dc.language.isoenen_US
dc.publisherMATTIOLI 1885en_US
dc.relation.ispartofPROGRESS IN NUTRITIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIdiopathic Short Statureen_US
dc.subjectL-arginine Supplementationen_US
dc.subjectGrowth Velocityen_US
dc.titleMultivitamin with L-Arginine supplementation can increase linear growth velocity in children with idiopathic short stature without affecting bone maturationen_US
dc.typeArticleen_US

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