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Öğe Patient-reported outcomes with cemiplimab versus chemotherapy in advanced non-small cell lung cancer (aNSCLC): geographic region subgroups in EMPOWER-Lung 1(Elsevier, 2022) Ho, Gwo Fuang; Sezer, Ahmet; Kılıçkap, Saadettin; Bondarenko, Igor; Özgüroğlu, Mustafa; Gogishvili, Miranda(Özet Yok / Not Abstract Avaliable)Öğe Gut microbiota-derived metabolite trimethylamine N-oxide and biomarkers of inflammation are linked to endothelial and coronary microvascular function in patients with inflammatory bowel disease(Elsevier, 2022) Kul, Sere; Caliskan, Zuhal; Güvenç, Tolga Sinan; Celik, Fatma Betul; Sarmis, Abdurrahman; Atici, AdemBackground: Inflammatory bowel disease (IBD), which is an umbrella term used for ulcerative colitis (UC) and Crohn's disease (CD), is associated with an increased risk for atherosclerotic cardiovascular disease (CVD). We aimed to investigate the association of local and systemic biomarkers of inflammation and gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) with endothelial and coronary microvascular dysfunction in IBD. Methods: A total of 56 patients with IBD (20 with UC and 36 with CD) and 34 age and gender matched controls were included. For all participants, samples were collected to analyze faecal calprotectin, and TMAO concentrations. Ultrasound-based examinations were done to measure flow-mediated vasodilatation (FMD) and coronary flow velocity reserve (CFVR). Results: Patients with IBD had lower CFVR (2.07 (1.82–2.40)) and FMD (8.7 ± 3.7) as compared to controls (2.30 (2.07–2.74), p = 0.005 and 11.9 ± 6.8, p = 0.03). In patients with IBD, TMAO concentration (r = ?0.30, p = 0.03), C-reactive protein (r = ?0.29, p = 0.03) and WBC count (r = ?0.37, p = 0.006) had a significant negative correlation with CFVR, and TMAO (? = ?0.27, 95 % CI: ?0.23 to ?0.02) and WBC count (? = ?0.31, 95 % CI: ?0.56 to ?0.06) were significant predictors of CFVR after multivariate adjustment. None of the biomarkers of inflammation or TMAO showed significant correlations with FMD. In patients with UC, TMAO showed a significant correlation with both CFVR (r = ?0.55, p = 0.01) and FMD (r = ?0.60, p = 0.005) while only WBC count had a statistically significant correlation with CFVR (r = ?0.49, p = 0.004) in patients with CD. Conclusions: Gut microbiota-derived metabolite TMAO and biomarkers of systemic inflammation are associated with measures of endothelial/coronary microvascular dysfunction in patients with IBD. © 2022Öğe By 2022, cancer is now a nore chronic disease with chronic difficulties to go along with It(Turkiye Klinikleri, 2022) Sümbül, Ahmet Taner; Sedef, Ali Murat; Karaçin, Cengiz; Bilir, Cemil; Akagündüz, BaranCancer is a disease in which some body cells with genetic or epigenetic changes become capable of replicating and invading other regions of the body uncontrollably. Numerous functional abilities and features are acquired by these cells during this multistage neoplastic process. In the last 20 years, many agents have been discovered and used in the fight against cancer. However, the use of these drugs in appropriate patient groups is still a serious problem. Many cancer types are on the way to becoming chronic diseases; conscientious physicians who are unable to provide appropriate treatment due to economic factors and other reasons face an additional burden.Öğe By 2022, cancer is now a more chronic disease with chronic difficulties to go along with It(Turkiye Klinikleri, 2022) Sümbül, Ahmet Taner; Sedef, Ali Murat; Karaçin, Cengiz; Bilir, Cemil; Akagündüz, BaranCancer is a disease in which some body cells with genetic or epigenetic changes become capable of replicating and invading other regions of the body uncontrollably. Numerous functional abilities and features are acquired by these cells during this multistage neo¬plastic process. In the last 20 years, many agents have been discovered and used in the fight against cancer. However, the use of these drugs in appropriate patient groups is still a serious problem. Many cancer types are on the way to becoming chronic diseases; conscientious physi¬cians who are unable to provide appropriate treatment due to economic factors and other reasons face an additional burden. © 2022 by Turkish Society of Medical Oncology.Öğe A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?(ISTANBUL UNIV, 2022) Eken, Hazal; Bektas, Nurcan; Arslan, RanaPain is sensed by the activation of painful nociceptors in the periphery or by pain mediators, such as bradykinin, serotonin, histamine, and prostaglandin, released from the damaged tissue, afferent transmission to the medulla spinalis, and by transmission stages to the high centers over the dorsal horn. Pain, which was seen as only a warning sign in the past, is now accepted as a phenomenon in itself that needs to be treated and the search for new, stronger active substances with fewer side effects in the treatment of pain is in demand. Hydrogen sulfide (H2S) is a modulator of T-type Ca+2 channels, especially in Cav3.2, which are known to play a critical role in the processing of pain. H2S can also show an anti-nociceptive effect by opening K+ channels and blocking nociceptors. Exciting preclinical data has demonstrated that H2S-derived Non-steroidal anti-inflammatory drugs (NSAIDs) and analgesic agents can be used to treat various types of pain. H2S increases the resistance of gastric mucosa against injury occurred by drugs used for pain relief and accelerates its repair, so it provides an advantage to derivatized drugs. In addition, H2S donors have also been shown to induce analgesia through mu-opioid receptors. Based on the studies, it is thought that the combination of H2S with opioid receptor agonists may provide an additive or even synergistic analgesic effect. It is estimated that the modification of H2S, with currently used analgesic drugs to prevent various side effects and increase analgesic effects, is a promising and wise approach.Öğe Effectiveness and safety transarterial embolization with bleomycin-loaded PLA/PLGA (polylactic acid)(poly[lactic-co-glycolic acid]) microspheres for treatment of vascular malformation using a porcine spleen model(Science Direct, 2019) Nurili, F.; Acar, T.; Derman, S.; Baş, A.; Caymaz, I.; Yurdaışık, Işıl; Çakıroğlu, H.; Özkanlı, S.; Aras, O.To prospectively study the effectiveness and safety of Bleomycin-loaded PLA/PLGA microparticles in the porcine spleen modelÖğe Transarterial embolization of prostate with biodegradable flutamide-loaded PLA/PLGA microspheres for benign prostate hyperplasia: preliminary study in a normal swine model(Science Direct, 2019) Nurili, F.; Acar, T.; Derman, S.; Baş, A.; Yurdaışık, Işıl; Özkanli, S.; Caymaz, I.; Çakıroğlu, H.; Aras, O.Purpose: To prospectively evaluate whether transarterial embolization with biodegradable flutamide-loaded PLA/PLGA microspheres with sustained-release properties in the prostate of swine can induce shrinkage in the volume of prostatic tissue. Flutamide is a strong nonsteroidal antiandrogen acts as selective, competitive and silent antagonist.Öğe Embolization of rabbit renal arteries to test feasibility and effects of CT-visible doxorubicin-eluting montmorillonite microparticles(Science Direct, 2019) Nurili, F.; Bekaroğlu, G.; İşçi, S.; Baş, A.; Caymaz, I.; Yurdaışık, Işıl; Özkanlı, S.; Çakıroğlu, H.; Aras, O.Purpose: To develop CT-visible doxorubicin (DOX)-eluting montmorillonite microparticles for transarterial embolization.Öğe Multifunctional iron oxide nanoparticle-embedded PVP-HEC microparticles as a drug-eluting embolic material(Science Direct, 2019) Nurili, F.; Bekaroğlu, G.; İşci, S.; Caymaz, I.; Baş, A.; Özkanlı, S.; Yurdaışık, Işıl; Çakıroğlu, H.; Aras, O.To develop MRI imageable novel HEC-PVP-magnetic embolic particles intended for transcatheter arterial chemoembolization and magnetic ablationÖğe Catheter-directed gastric artery embolization with octreotide acetate loaded PLA/PLGA (poly[lactide-co-glycolide] acid) microspheres with slow sustained-release properties suppresses the plasma concentration of ghrelin, which results in weight loss(Science Direct, 2019) Nurili, Fuad; Acar, T.; Derman, S.; Baş, A.; Caymaz, I.; Özkanlı, S.; Çakıroğlu, H.; Yurdaışık, Işıl; Aras, O.Purpose: The objective of the present work was to formulate slow- and sustained-release octreotide acetate-loaded PLA/PLGA (polylactide)(poly (Lactic-co- Glycolic) acid) microspheres and prospectively test the effects of catheter-directed gastric artery administration of these microspheres on plasma ghrelin levels and body weight in swineÖğe Kidney transplantation in children weighing 15 kilograms or less(SPRINGER, 2021) Özkaya, Ozan; Evrengül, Havva; Eren, Eryiğit; Tokaç, Mehmet; Yaman, Ayhan; Şahin, Taylan; Sütçü, Murat; Dursun, İsmail; Dinçkan, Ayhan[No Abstract Available]Öğe Stem cell transplantation for high-risk acute lymphoblastic leukemia in a developing country: a single-center experience(WILEY, 2020) Bozkurt, Ceyhun; Aksoy, B.; Aydoğdu, S.; Bozkurt, Süreyya; Erol Çipe, Funda; Öner, O.; Özsoy, S.; Fışgın, T.: Allogeneic stem cell transplantation in patients with a diagnosis of high-risk acute lymphoblastic leukemia results in high rates of survival in developed countries. Our aim with this presentation was to share our center’s experience on this subject. Methods: Hematopoietic stem cell transplantation was performed in a total of 69 patients with a diagnosis of high-risk acute lymphoblastic leukemia between 2015 and 2020 at our center. The demographic and treatment-related information of the patients was retrospectively evaluated.Öğe Demographic, clinical, and laboratory characteristics of elderly onset psoriatic arthritis(Bmj Publishing Group, 2017) Kobak, Şenol; Orman, Mehmet AkifBackground: Psoriatic arthritis (PsA) is a chronic in?amatory disease characterized with axial and peripheral joints involvement. It is rarely affects patients older than 65 years old. Objectives: The purpose of this study is to compare and evaluate the demographic,clinicalandlaboratoryfeaturesofelderly-onsetpsoriaticarthritis(EOPsA) and young-onset (YOPsA) patients. Methods: One hundred and eighty patients diagnosed with PsA according to CASPAR criteria and followed-up in single center were included in this study. The patients with initial symptoms started after age 65 were accepted as EOPsA. Demographic,clinical,andlaboratorydataandthemedicationswhichthepatients recieved were recorded and retrospectively evaluated. Results: Nineteen (10.5%)of 180 patients were diagnosed as EOPsA, and 161 (89.5%) patients were evaluated as YOPsA. Mean patient age was 42.1years for YOPsA group and 68.3years for elderly onset group. Mean duration of disease was 5.6 years for early onset group and 1.3 years for elderly onset group (p=0.001). Fourteen (73.3%) of 19 EOPsA patients were female and 5 of them were male. Higher rates of fatique, pain scores, comorbid diseases and acute phase reactants were detected in EOPsA patients comparing to YOPsA (p=0.000, p=0.000, p=0.001 and p=0.001 respectively). YOPsA patients have more dactilitis, nail involvement, elevated PASI scores, and smoking habitus when comparedwithEOPsApatients(p=0.019,p=0.03,p=0.005,p=0.004respectively). In terms of the treatment options chosen, there was no signi?cant difference in the use of non-steroidal anti-in?ammatory drugs (NSAIDs), corticosteroids (CS), methotrexate (MTX), and sulfasalazine (SSL), but there was a more frequent use of anti-tumor necrosis factor -alpha in YOPsA group. Conclusions: Herein we showed that YOPsA and EOPsA patients may have different demographic, clinical, and laboratory features. EOPsA patients are characterized with higher rates of fatique, pain scores, comorbid diseases, and acute phase reactants and less dactilitis, nail involvement and anti-TNF-alpha usage.Öğe Concomitant autoimmune diseases in patients with sarcoidosis(Bmj Publishing Group, 2017) Kobak, Şenol; Sever, Fidan; Semiz, Hüseyin; Orman, Mehmet NurullahSarcoidosis is a chronic granulomatous disease characterized by non-caseating granuloma formation. It can mimic many rheumatic diseases and/or may be coexist with them. There are limited data in the literature about the association of sarcoidosis with autoimmune diseases.Öğe Elderly - onset sarcoidosis: a single center comparative study(Wiley, 2017) Kobak, Şenol; Yıldız, Fidan; Semiz, Hüseyin; Orman, Mehmet[No Abstract Available]Öğe Development of independent mu/treatment time verification algorithm for non-imrt treatment planning: a clinical experience(Amer Inst Physics, 2018) Tatlı, Hamza; Yücel, Derya; Yılmaz, Sercan; Fayda, MerdanThe aim of this study is to develop an algorithm for independent MU/treatment time (TT) verification for non-IMRT treatment plans, as a part of QA program to ensure treatment delivery accuracy. Two radiotherapy delivery units and their treatment planning systems (TPS) were commissioned in Liv Hospital Radiation Medicine Center, Tbilisi, Georgia. Beam data were collected according to vendors' collection guidelines, and AAPM reports recommendations, and processed by Microsoft Excel during in-house algorithm development. The algorithm is designed and optimized for calculating SSD and SAD treatment plans, based on AAPM TG114 dose calculation recommendations, coded and embedded in MS Excel spreadsheet, as a preliminary verification algorithm (VA). Treatment verification plans were created by TPSs based on IAEA TRS 430 recommendations, also calculated by VA, and point measurements were collected by solid water phantom, and compared. Study showed that, in-house VA can be used for non-IMRT plans MU/TT verifications.Öğe Malignancy in patients with sarcoidosis: a retrospective cohort study from Turkey(Bmj Publishing Group, 2018) Kobak, Şenol; Yıldız, Figen; Semiz, Hüseyin; Orman, Mehmet AkifThe relationship between sarcoidosis and malignancy is not clear yet. There is debate with different speculations in the literature in this regard, that this association may be just a coincidence and/or common pathogenetic link. Objectives: The goal of our study was to evaluate the incidence and characteris-tics of malignancy in patients with sarcoidosis follow-up in a single centre.Öğe Assessment of serum vitamin D in pediatric hematopoietic stem cell transplantation patients and its relation with complications(Nature Publishing Group, 2018) Karakaş, Zeynep; Aydoğdu, Selime; Yılmaz, Yasin; Bozkurt, Ceyhun; Aykanat, Alper; Fışgın, TunçRecently, evaluation of serum vitamin D level in pediatric hematopoietic stem cell transplantation (HSCT) patients gained popularity, as there is close relation with development of GVHD and complications. Our aim was to assess the serum vitamin D level and its relation with GVHD and complications such as graft failure in HSCT patients.Öğe The evaluation of left ventricular functions in children with steroid-sensitive nephrotic syndrome(Springer, 2018) Nalcacıoğlu, Hülya; Özkaya, Ozan; Kafalı, Candaş; Tekcan, Demet; Baysal, Kemal: Nephrotic syndrome has been associated with increased risk of cardiovascular diseases (CVD), which may be attributable to the hypoalbuminemia, dyslipidemia, hypercoagulopathy or inflammatory activation. In childhood minimal change disease is less prone to CVD because of the transient nature of the metabolic abnormalities and steroid exposure. The aim of the present study was to evaluate the presence of cardiac systolic and diastolic dysfunction in pediatric patients with steroid – sensitive nephrotic syndrome (SSNS).Öğe A single center study of the patients with cystinuria(Springer, 2018) Tekcan, Demet; Aydoğ, Özlem; Genç, Gürkan; Kendirci, Nergis; Nalçacıoğlu, Hülya; Özkaya, Ozanbe partially treated with bicarbonate, bone marrow transplantation or possibly gene therapy.
