Cytochrome P450 (inhibitors for the metabolism of drugs)

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dc.contributor.authorAkdemir, A.
dc.date.accessioned2024-05-19T14:33:53Z
dc.date.available2024-05-19T14:33:53Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractDrug-metabolizing enzymes, such as P450 3A4, are key determinants of the pharmacokinetics of drugs and as such are key factors in pharmacotherapy. Pharmacokinetic enhancers, also known as pharmacokinetic boosters, cause intended drug-drug interactions by inhibiting drug-metabolizing enzymes and increasing the bioavailability of target drugs. In this chapter, the focus will be mainly on the structure, function and physiology of the most important drug metabolizing P450 enzyme 3A4 as well as its inhibitors with a specific emphasis on pharmacokinetic boosters. © 2024 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-12-823974-2.00012-7
dc.identifier.endpage457en_US
dc.identifier.isbn9780128239742
dc.identifier.isbn9780128242353
dc.identifier.scopus2-s2.0-85176818939en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage449en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-823974-2.00012-7
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4362
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMetalloenzymes: From Bench to Bedsideen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDrug-Metabolizing Enzymesen_US
dc.subjectP450 3a4en_US
dc.subjectPharmacokinetic Boostersen_US
dc.subjectPharmacokinetic Enhancersen_US
dc.titleCytochrome P450 (inhibitors for the metabolism of drugs)en_US
dc.typeBook Chapteren_US

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