Dispersive solid phase extraction and quadruple isotope dilution-mass spectrometry combination for the accurate and sensitive quantification of capsaicin in pepper, domestic wastewater and human saliva samples by GC-MS system

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dc.authoridSuleyman Bodur / 0000-0002-2994-9047
dc.authoridSezin Erarpat Bodur / 0000-0002-9879-6662
dc.authoridSelim Gursoy / 0000-0003-3233-0728
dc.authoridMerve Firat Ayyildiz / 0000-0003-3523-8169
dc.authoridBedrihan Kartoglu
dc.authoridHilal Akbiyik
dc.authoridOmer Tahir Gunkara
dc.authoridSezgin Bakirdere / 0000-0001-9746-3682
dc.authorscopusidSuleyman Bodur / 57202493954
dc.authorwosidSuleyman Bodur / AHB-4581-2022
dc.contributor.authorBodur, Suleyman
dc.contributor.authorBodur, Sezin Erarpat
dc.contributor.authorGursoy, Selim
dc.contributor.authorAyyildiz, Merve Firat
dc.contributor.authorKartoglu, Bedrihan
dc.contributor.authorAkbiyik, Hilal
dc.contributor.authorGunkara, Omer Tahir
dc.contributor.authorBakirdere, Sezgin
dc.date.accessioned2025-05-30T12:12:40Z
dc.date.available2025-05-30T12:12:40Z
dc.date.issued16.12.2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Bölümü
dc.description.abstractIn the presented study, reduced graphene oxide/Fe3O4 (rGO/Fe3O4) nanocomposites based dispersive solid phase extraction (DSPE) - gas chromatography-mass spectrometry (GC-MS) method was developed for the determination of capsaicin in domestic wastewater (DW), pepper (PP) and human saliva (HS) samples. All important parameters of the DSPE method affected the preconcentration factor were carefully optimized to achieve high signal to noise ratio for the analyte. After the optimization studies, the system analytical performance of DSPEGC-MS system was evaluated using the aqueous standard solution of capsaicin. Limit of detection (LOD), limit of quantitation (LOQ) and dynamic range were figured out to be 0.54 mu g/kg, 1.80 mu g/kg and 2.66 - 487.35 mu g/kg, respectively. Under the optimum experimental conditions, recovery studies were conducted with the spiked DW, PP and HS samples, and percent recovery results were recorded between 52.6 % and 183.6 % via matrix matching calibration strategy. After the implementation of ID4 strategy, percent recovery results for the spiked DW, PP and HS samples were calculated as 98.2 %-99.3 %, 99.7 %-100.7 % and 99.4 %-99.8 %, respectively. In addition, capsaicin content in Sivri (S)-PP, Kil (K)-PP and Samandag (SA)-PP samples were found to be 309.5 +/- 11.8 mg/kg, 873.7 +/- 26.7 mg/kg and 165.3 +/- 5.1 mg/kg via DSPE-GC-ID4-MS method, respectively. As a result, the combination of quadruple isotope dilution (ID4) strategy and the DSPE-GC-MS method were successfully performed to boost the accuracy and precision of developed DSPE-GC-MS method.
dc.identifier.citationBodur, S., Bodur, S. E., Gürsoy, S., Ayyıldız, M. F., Kartoğlu, B., Akbıyık, H., ... & Bakırdere, S. (2025). Dispersive solid phase extraction and quadruple isotope dilution–mass spectrometry combination for the accurate and sensitive quantification of capsaicin in pepper, domestic wastewater and human saliva samples by GC–MS system. Microchemical Journal, 208, 112246.
dc.identifier.doi10.1016/j.microc.2024.112246
dc.identifier.issn0026-265X
dc.identifier.scopus2-s2.0-85210536558
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:001370602800001
dc.identifier.urihttps://doi.org/10.1016/j.microc.2024.112246
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7259
dc.identifier.wosWOS:001370602800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBodur, Suleyman
dc.institutionauthoridSuleyman Bodur / 0000-0002-2994-9047
dc.language.isoen
dc.publisherELSEVIER
dc.relation.ispartofMICROCHEMICAL JOURNAL
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDIHYDROCAPSAICINNANOPARTICLESSEAWATER
dc.titleDispersive solid phase extraction and quadruple isotope dilution-mass spectrometry combination for the accurate and sensitive quantification of capsaicin in pepper, domestic wastewater and human saliva samples by GC-MS system
dc.typeArticle

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