Kronik obstrüktif akciğer hastalığının retina sinir lifi tabakası ve ganglion hücre kompleksi üzerine etkisi
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Tarih
2017
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Kronik obstrüktif akciğer hastalığı olan olguların retina sinir lifi tabakası ve ganglion hücre kompleksi kalınlığının değerlendirilmesi ve sağlıklı bireylerle karşılaştırılması amaçlanmıştır.Gereç ve Yöntem: Kronik obstrüktif akciğer hastalığı tanısı ile takip edilen olgular (Grup 1) ile hafif refraktif kusurları dışında bulgususaptanmayan sağlıklı bireyler (Grup 2) çalışmaya dahil edildi. Grup 1'de solunum fonksiyon testleri ve Global Initiative for ChronicObstructive Lung Disease kriterlerine göre kronik obstrüktif akciğer hastalığı tanısı alan ve takip edilen, herhangi bir göz hastalığı ve geçirilmiş göz cerrahisi bulunmayan hastalar çalışmaya alındı. Ayrıntılı oftalmolojik muayenenin ardından optik koherAns tomografi ile ortalama,üst, nazal, alt ve temporal kadran retina sinir lifi tabakası ve ortalama, minimum, üst, üst temporal, üst nazal, alt, alt temporal ve alt nazal kadran ganglion hücre kompleksi kalınlıkları ölçülerek, iki grup istatistiksel olarak karşılaştırıldı. İstatistiksel analiz bağımsız gruplar için nonparametrik Mann Whitney-U testi ile yapıldı.Bulgular: Kronik obstrüktif akciğer hastalığı tanılı 26 hastanın 51 gözü ile sağlıklı 20 olgunun 40 gözü değerlendirmeye alındı. İki gruparasında yaş, cinsiyet ve en iyi düzeltilmiş görme keskinliği açısından istatistiksel olarak anlamlı fark bulunmadı (p=0,571). Kronik obstrüktifakciğer hastalığı olan olguların takip süresi ortalama 7,4 ± 8,3 (2-35yıl) yıl idi. Temporal kadran retina sinir lifi tabakası kalınlığı kronikobst rüktif akciğer hastalığı olan olgularda kontrol grubuna göre daha ince bulundu (p=0,004). Ortalama, minimum, üst, üst nazal, alt ve altnazal kadran ganglion hücre kompleksi kalınlıkları da yine kronik obstrüktif akciğer hastalığı olan olgularda istatistiksel olarak anlamlı düzeyde ince bulundu (p<0,05).Tartışma: Çalışmamızda ganglion hücre kompleksi ve retina sinir lifi tabakası kalınlıklarının kronik obstrüktif akciğer hastalığından etkilendiği gösterilmiştir. Bu sonuç, kronik hipoksiye bağlı artmış vasküler rezistans ve azalmış kan akımı sebebiyle oluşan nörodejeneratif sürecebağlı olabilir.
Objective: To evaluate retinal nerve fiber layer thickness and ganglion cell complex thickness in patients with chronic obstructive pulmonary disease and to compare results with healthy individuals. Material and Method: Patients with chronic obstructive pulmonary disease (Group 1) and healthy subjects who have no problems except minimal refractive findings (Group 2) were included in the study. Group 1 consisted of patients with chronic obstructive pulmonary disease according to respiratory function test and Global Initiative for Chronic Obstructive Lung Disease criterias and without any ocular diseases and history of ophthalmic surgery. After detailed ophthalmological examination, mean and superior, temporal, inferior, nasal quadrants of retinal nerve fiber layer and mean, minimum and superior, superotemporal, superonasal, inferior, inferotemporal, inferonasal quadrants of ganglion cell complex thicknesses were measured by optic coherence tomography and were compared statistically between two groups. Non-parametric Mann Whitney-U test was used for statistical analysis. Results: Fifty one eyes of 26 patients with chronic obstructive pulmonary disease and 40 eyes of 20 healthy subjects were evaluated. No statistical difference was found in mean age, gender and best corrected visual acuities between two groups. The mean follow-up time of patients with chronic obstructive pulmonary disease was 7.4±8.3 (2-35 years) years. Temporal quadrant retinal nerve fiber layer thickness was found to be thinner in patients with chronic obstructive pulmonary disease (p=0.004). The mean, minimum, superior, superonasal, inferior, inferonasal quadrants thicknesses of ganglion cell complex were also found to be statistically thinner in chronic obstructive pulmonary disease group (p<0.05). Conclusion: In our study, ganglion cell complex and retinal nerve fiber layer thicknesses were found to be thinner in patients with chronic obstructive pulmonary disease. This result may be related to neurodegenerative process because of increased vascular resistance and decreased blood flow due to chronic hypoxia.
Objective: To evaluate retinal nerve fiber layer thickness and ganglion cell complex thickness in patients with chronic obstructive pulmonary disease and to compare results with healthy individuals. Material and Method: Patients with chronic obstructive pulmonary disease (Group 1) and healthy subjects who have no problems except minimal refractive findings (Group 2) were included in the study. Group 1 consisted of patients with chronic obstructive pulmonary disease according to respiratory function test and Global Initiative for Chronic Obstructive Lung Disease criterias and without any ocular diseases and history of ophthalmic surgery. After detailed ophthalmological examination, mean and superior, temporal, inferior, nasal quadrants of retinal nerve fiber layer and mean, minimum and superior, superotemporal, superonasal, inferior, inferotemporal, inferonasal quadrants of ganglion cell complex thicknesses were measured by optic coherence tomography and were compared statistically between two groups. Non-parametric Mann Whitney-U test was used for statistical analysis. Results: Fifty one eyes of 26 patients with chronic obstructive pulmonary disease and 40 eyes of 20 healthy subjects were evaluated. No statistical difference was found in mean age, gender and best corrected visual acuities between two groups. The mean follow-up time of patients with chronic obstructive pulmonary disease was 7.4±8.3 (2-35 years) years. Temporal quadrant retinal nerve fiber layer thickness was found to be thinner in patients with chronic obstructive pulmonary disease (p=0.004). The mean, minimum, superior, superonasal, inferior, inferonasal quadrants thicknesses of ganglion cell complex were also found to be statistically thinner in chronic obstructive pulmonary disease group (p<0.05). Conclusion: In our study, ganglion cell complex and retinal nerve fiber layer thicknesses were found to be thinner in patients with chronic obstructive pulmonary disease. This result may be related to neurodegenerative process because of increased vascular resistance and decreased blood flow due to chronic hypoxia.
Açıklama
Anahtar Kelimeler
Kronik Obstrüktif Akciğer Hastalığı, Ganglion Hücre Kompleksi, Retina Sinir Lifi Tabakası, Chronic Obstructive Pulmonary Disease, Ganglion Cell Complex, Retinal Nerve Fiber Layer
Kaynak
MN Oftalmoloji
WoS Q Değeri
Scopus Q Değeri
Cilt
24
Sayı
4
Künye
AKSOY N. Ö,ÇAKIR B,GÜNGEN A. C,ÇELİK E,BURSALI Ö,ALAGÖZ G (2017). Kronik Obstrüktif Akciğer Hastalığının Retina Sinir Lifi Tabakası ve Ganglion Hücre Kompleksi Üzerine Etkisi. MN Oftalmoloji, 24(4), 221 - 225.
